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Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA
Open accessAbstract
We report the complete nucleotide sequence of a human beta actin cDNA. Both the 5' and 3' untranslated regions of the sequence are similar (greater than 80%) to the analogous regions of the rat beta-actin gene reported by Nudel et al (1983). When a segment of the 3' untranslated region is used as a radiolabelled probe, strong hybridization to chick beta actin mRNA is seen. This conservation of sequences suggests that strong selective pressures operate on non-translated segments of beta actin mRNA.
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Cited by
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Wong, G. H. W., & Goeddel, D. V. (1988) · Science · doi:10.1126/science.3263703 · Cited by 914
Wong, G. H. W., Elwell, J. H., Oberley, L. W., & Goeddel, D. V. (1989) · Cell · doi:10.1016/0092-8674(89)90944-6 · Cited by 802
Increased ratio of targeted to random integration after transfection of chicken B cell lines
Buerstedde, J.-M., & Takeda, S. (1991) · Cell · doi:10.1016/0092-8674(91)90581-i · Cited by 538
Normington, K., & Russell, D. W. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41809-1 · Cited by 379
(2003) · PubMed · Cited by 355
Metadata
- Authors
- Ponte, P., Ng, S.-Y., Engel, J., Gunning, P., & Kedes, L.
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1984
- Volume
- 12
- Issue
- 3
- Pages
- 1687-1696
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- OpenAlex
- W2092602709
- Cited by
- 936
- References
- 0
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. https://app.cochat.ai/papers/10.1093/nar/12.3.1687
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- Ponte, P., Ng, S.-Y., Engel, J., Gunning, P., & Kedes, L. (1984). Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. Nucleic Acids Research. https://doi.org/10.1093/nar/12.3.1687
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