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Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA

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Ponte, Phyllis, Ng, Sun-Yu, Engel, Joanne, Gunning, Peter, Kedes, Larry·1984·Nucleic Acids Research

Abstract

We report the complete nucleotide sequence of a human beta actin cDNA. Both the 5' and 3' untranslated regions of the sequence are similar (greater than 80%) to the analogous regions of the rat beta-actin gene reported by Nudel et al (1983). When a segment of the 3' untranslated region is used as a radiolabelled probe, strong hybridization to chick beta actin mRNA is seen. This conservation of sequences suggests that strong selective pressures operate on non-translated segments of beta actin mRNA.

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Authors
Ponte, P., Ng, S.-Y., Engel, J., Gunning, P., & Kedes, L.
Venue
Nucleic Acids Research
Published
1984
Volume
12
Issue
3
Pages
1687-1696
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W2092602709
Cited by
936
References
0
FWCI
6.17
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. https://app.cochat.ai/papers/10.1093/nar/12.3.1687
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Ponte, P., Ng, S.-Y., Engel, J., Gunning, P., & Kedes, L. (1984). Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. Nucleic Acids Research. https://doi.org/10.1093/nar/12.3.1687

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