The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells.
Open accessAbstract
Curcumin, a dietary pigment responsible for the yellow color of curry, is a potent inhibitor of tumor promotion by phorbol esters. Functional activation of transcriptional factor c-Jun/AP-1 is believed to play an important role in signal transduction of phorbol 12-myristate 13-acetate-induced tumor promotion. Suppression of the c-Jun/AP-1 activation by curcumin is observed in mouse fibroblast cells. In vitro experiments indicate that inhibition of c-Jun/AP-1 binding to its cognate motif by curcumin may be responsible for the inhibition of c-Jun/AP-1-mediated gene expression. These findings show that the effect of curcumin on phorbol 12-myristate 13-acetate-induced inflammation/tumor promotion could be studied at the molecular level.
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Cites
Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro
Abate, C., Patel, L., Rauscher, F. J., & Curran, T. (1990) · Science · doi:10.1126/science.2118682 · Cited by 1,573
Yang-Yen, H.-F., Chambard, J.-C., Sun, Y.-L., Smeal, T., Schmidt, T. J., Drouin, J., & Karin, M. (1990) · Cell · doi:10.1016/0092-8674(90)90396-v · Cited by 1,553
Bohmann, D., Bos, T. J., Admon, A., Nishimura, T., Vogt, P. K., & Tjian, R. (1987) · Science · doi:10.1126/science.2825349 · Cited by 1,321
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
Angel, P., Hattori, K., Smeal, T., & Karin, M. (1988) · Cell · doi:10.1016/0092-8674(88)90143-2 · Cited by 1,239
AP1/ jun Function Is Differentially Induced in Promotion-Sensitive and Resistant JB6 Cells
Bernstein, L. R., & Colburn, N. H. (1989) · Science · doi:10.1126/science.2541502 · Cited by 207
Cited by
Surh, Y.-J. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s1383-5742(99)00057-5 · Cited by 633
Metadata
- Authors
- Huang, T. S., Lee, S. C., & Lin, J. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-06-15
- Volume
- 88
- Issue
- 12
- Pages
- 5292-5296
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1975055683
- Cited by
- 374
- References
- 5
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- green
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