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A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.
Open accessAbstract
Mutations in the unc-13 gene cause diverse defects in the nervous system of the nematode Caenorhabditis elegans. Molecular cloning of the gene and sequencing of the cDNA revealed that the product encodes a protein, 1734 amino acids in length, with a central domain with sequence similarity to the regulatory region of protein kinase C. The domain was expressed in Escherichia coli and shown to bind specifically to a phorbol ester in the presence of calcium; diacylglycerol inhibited the binding in a competitive manner. These findings confirm that the unc-13 gene product has binding sites similar to those of protein kinase C and may be a component of an alternative transduction pathway of the diacylglycerol signal to a different effector function in the nervous system.
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Cited by
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Südhof, T. C. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.012 · Cited by 1,062
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Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
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Metadata
- Authors
- Maruyama, I. N., & Brenner, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-07
- Volume
- 88
- Issue
- 13
- Pages
- 5729-5733
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2028679115
- Cited by
- 255
- References
- 0
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans. https://app.cochat.ai/papers/10.1073/pnas.88.13.5729
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- Maruyama, I. N., & Brenner, S. (1991). A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.13.5729
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