The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
High density lipoprotein loses its effect to stimulate efflux of cholesterol from foam cells after oxidative modification.
Open accessAbstract
In this study, we performed oxidative modification of high density lipoprotein (HDL) in vitro. The amount of lipid peroxide increased when either HDL2 or HDL3 was incubated with phosphate-buffered saline containing 5 microM CuSO4 for 24 h at 37 degrees C, indicating that both fractions of HDL were oxidatively modified. This modification resulted in denaturation of apolipoprotein AI on SDS/PAGE and increased the negative charge on agarose gel electrophoresis. When incubated with macrophage-derived foam cells, native HDL caused a marked efflux of cholesterol from them, leading to a decrease in the amount of cholesteryl ester in the cells. However, oxidized HDL showed a lessened effect on the decrease of cholesteryl ester in foam cells. These data suggest that oxidative modification of HDL may stimulate development of atherosclerosis by limiting efflux of cholesterol from foam cells.
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Brown, M. S., Ho, Y. K., & Goldstein, J. L. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70568-7 · Cited by 722
Cited by
Sorrentino, S. A., Besler, C., Rohrer, L., Meyer, M., Heinrich, K., Bahlmann, F. H., Mueller, M., Horváth, T., Doerries, C., Heinemann, M., et al. (2010) · Circulation · doi:10.1161/circulationaha.108.836346 · Cited by 402
Atheroprotective mechanisms of HDL
Stein, O., & Stein, Y. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00065-9 · Cited by 316
Structural Modifications of HDL and Functional Consequences
Ferretti, G., Bacchetti, T., Nègre-Salvayre, A., Salvayre, R., Dousset, N., & Curatola, G. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.08.008 · Cited by 176
Metadata
- Authors
- Nagano, Y., Arai, H., & Kita, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-08
- Volume
- 88
- Issue
- 15
- Pages
- 6457-6461
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2086440407
- Cited by
- 245
- References
- 1
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: High density lipoprotein loses its effect to stimulate efflux of cholesterol from foam cells after oxidative modification. https://app.cochat.ai/papers/10.1073/pnas.88.15.6457
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- Nagano, Y., Arai, H., & Kita, T. (1991). High density lipoprotein loses its effect to stimulate efflux of cholesterol from foam cells after oxidative modification. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.15.6457
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
