The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.
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Continual hydrolysis and re-esterification of droplet cholesterol is a futile cycle that wastes ATP and contributes to premature death of foam cells in poorly oxygenated atherosclerotic regions.
“the continual hydrolysis and re-esterification of droplet cholesterol constitutes a futile cycle that wastes ATP and thereby contributes to the premature death of the foam cells in poorly oxygenated regions of atherosclerotic lesions24,25.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [24]
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- Authors
- Brown, M. S., Ho, Y. K., & Goldstein, J. L.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1980-10
- Volume
- 255
- Issue
- 19
- Pages
- 9344-9352
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1940775645
- Cited by
- 722
- References
- 17
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 11 · 2019: 16 · 2018: 4 · 2017: 12 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 14 · 2012: 8
- FWCI
- 33.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- foam cells, cholesterol ester hydrolysis, re-esterification
- MeSH terms
- Acetylation, Ammonium Chloride, Animals, Cells, Cultured, Chloroquine, Cholesterol Esters, Female, Humans, Kinetics, Lipoproteins, HDL, Lipoproteins, LDL, Macrophages, Male, Progesterone, Tritium, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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