Cited by 724Cholesterol and Lipid MetabolismLipid metabolism and biosynthesisLipid metabolism and disorders

The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.

Open access
Brown, M.S., Ho, Y.K., Goldstein, J.L.·1980·Journal of Biological Chemistry

Integrity signals

Registry

Crossref · 10.1016/s0021-9258(19)70568-7

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

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Claims other papers make about this one

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  • Continual hydrolysis and re-esterification of droplet cholesterol is a futile cycle that wastes ATP and contributes to premature death of foam cells in poorly oxygenated atherosclerotic regions.

    “the continual hydrolysis and re-esterification of droplet cholesterol constitutes a futile cycle that wastes ATP and thereby contributes to the premature death of the foam cells in poorly oxygenated regions of atherosclerotic lesions24,25.”

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Authors
Brown, M. S., Ho, Y. K., & Goldstein, J. L.
Affiliations
The University of Texas Southwestern Medical Center (US)
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1980-10
Volume
255
Issue
19
Pages
9344-9352
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1940775645
Cited by
722
References
17
Citations by year
2026: 3 · 2025: 1 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 8 · 2020: 11 · 2019: 16 · 2018: 4 · 2017: 12 · 2016: 6 · 2015: 9 · 2014: 6 · 2013: 14 · 2012: 8
FWCI
33.75
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords
foam cells, cholesterol ester hydrolysis, re-esterification
MeSH terms
Acetylation, Ammonium Chloride, Animals, Cells, Cultured, Chloroquine, Cholesterol Esters, Female, Humans, Kinetics, Lipoproteins, HDL, Lipoproteins, LDL, Macrophages, Male, Progesterone, Tritium, Mice

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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