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Parameters of the human genome.
Open accessAbstract
Chromosome arm lengths are the critical parameters of the human genome. The physical length is required to scale radiation hybrid and other maps to megabases. The genetic lengths in males and females are required for probabilities of exclusion and synteny, choice of well-spaced loci for linkage tests, and comparison with centromeric maps based on nondisjunction. Interpolation of new data into a map is possible only when the length is known, including the distances from centromere and telomeres to the nearest markers. Current evidence on physical parameters including the reliable measurements of relative lengths from flow cytometry but only a crude estimate of genome size (3200 megabases). Evidence on genetic parameters includes chiasma counts and linkage maps corrected for failure to sample telomeres, giving an autosomal size of 2809 centimorgans in males and 4782 centimorgans in females. Estimates of the physical and sex-specific genetic lengths are presented for each chromosome arm. Any linkage analysis that yields substantially larger estimates raises a suspicion of an inappropriate mapping function or typing errors.
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Cited by
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray
Schena, M., Shalon, D., Davis, R. W., & Brown, P. O. (1995) · Science · doi:10.1126/science.270.5235.467 · Cited by 9,609
Finishing the euchromatic sequence of the human genome
International Human Genome Sequencing Consortium (2004) · Nature · doi:10.1038/nature03001 · Cited by 4,971
Miah, G., Rafii, M., Ismail, M., Puteh, A., Rahim, H., Islam, K., & Latif, M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141122499 · Cited by 241
Chromosome aberrations as biomarkers of radiation exposure: modelling basic mechanisms
Ballarini, F., & Ottolenghi, A. (2003) · Advances in Space Research · doi:10.1016/s0273-1177(03)00091-7 · Cited by 41
Ottolenghi, A., Ballarini, F., & Merzagora, M. (1999) · Radiation and Environmental Biophysics · doi:10.1007/s004110050132 · Cited by 36
Metadata
- Authors
- Morton, N. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-09
- Volume
- 88
- Issue
- 17
- Pages
- 7474-7476
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2039128321
- Cited by
- 516
- References
- 0
- FWCI
- 14.06
- Type
- journal article
- Language
- en
- Open access
- green
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