The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cholesterol-induced fluid-phase immiscibility in membranes.
Open accessAbstract
The fluid-phase behavior of binary mixtures of cholesterol with phosphatidylcholines is investigated using magnetic resonance methods. Phospholipid biradicals provide the electron spin resonance spectroscopic resolution of two immiscible fluid phases in the dipalmitoylphosphatidylcholine-cholesterol system. Isotropic chemical shifts of the phospholipid carbonyl carbons in binary mixtures with cholesterol measured using solid-state high-resolution nuclear magnetic resonance methods furnish evidence for a putative hydrogen bond between the 3 beta-hydroxyl of cholesterol and the sn-2 carbonyl of the phospholipid. The location in the bilayer of cholesterol in the two fluid phases is determined by measuring spin label-enhanced spin-lattice relaxation rates of the 13C nuclei of both the phospholipid and cholesterol molecules. These results suggest, in a time-averaged sense, that in the cholesterol-poor fluid phase the cholesterol molecule essentially spans the bilayer, whereas in the cholesterol-rich fluid phase the molecule is present in both monolayers of the bilayer.
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Cites
Vist, M. R., & Davis, J. H. (1990) · Biochemistry · doi:10.1021/bi00454a021 · Cited by 1,112
Phase equilibria in the phosphatidylcholine-cholesterol system
Hjort Ipsen, J., Karlström, G., Mourtisen, O. G., Wennerström, H., & Zuckermann, M. J. (1987) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(87)90020-4 · Cited by 1,059
Mabrey, S., Mateo, P. L., & Sturtevant, J. M. (1978) · Biochemistry · doi:10.1021/bi00605a034 · Cited by 408
Interaction of cholesterol with various glycerophospholipids and sphingomyelin
Sankaram, M. B., & Thompson, T. E. (1990) · Biochemistry · doi:10.1021/bi00499a014 · Cited by 315
Self-citationThe Planar Organization of Lecithin-Cholesterol Bilayers
Engelman, D. M., & Rothman, J. E. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45196-x · Cited by 248
Phase equilibriums in binary mixtures of phosphatidylcholine and cholesterol
Recktenwald, D. J., & McConnell, H. M. (1981) · Biochemistry · doi:10.1021/bi00518a042 · Cited by 244
Sankaram, M. B., & Thompson, T. E. (1990) · Biochemistry · doi:10.1021/bi00499a015 · Cited by 238
Self-citationInterdigitated bilayer membranes
Slater, J. L., & Huang, C.-H. (1988) · Progress in Lipid Research · doi:10.1016/0163-7827(88)90010-0 · Cited by 227
A structural model for the cholesterol‐phosphatidylcholine complexes in bilayer membranes
Huang, C. (1977) · Lipids · doi:10.1007/bf02533637 · Cited by 203
A method for the synthesis of isomerically pure saturated mixed-chain phosphatidylcholines
Mason, J. T., Broccoli, A. V., & Huang, C.-H. (1981) · Analytical Biochemistry · doi:10.1016/0003-2697(81)90049-x · Cited by 164
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Anderson, T. M., Clay, M. C., Cioffi, A. G., Diaz, K. A., Hisao, G. S., Tuttle, M. D., Nieuwkoop, A. J., Comellas, G., Maryum, N., Wang, S., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1496 · Cited by 528
Brown, D. A., & London, E. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7575 · Cited by 517
The differential miscibility of lipids as the basis for the formation of functional membrane rafts
Rietveld, A., & Simons, K. (1998) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(98)00019-7 · Cited by 513
Influenza Viruses Select Ordered Lipid Domains during Budding from the Plasma Membrane
Scheiffele, P., Rietveld, A., Wilk, T., & Simons, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2038 · Cited by 448
Characterization of Cholesterol-Sphingomyelin Domains and Their Dynamics in Bilayer Membranes
Samsonov, A. V., Mihalyov, I., & Cohen, F. S. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)75803-1 · Cited by 438
Metadata
- Authors
- Sankaram, M. B., & Thompson, T. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-10
- Volume
- 88
- Issue
- 19
- Pages
- 8686-8690
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2080868439
- Cited by
- 311
- References
- 10
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
