The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide.
Open accessAbstract
The major histocompatibility complex class I molecule HLA-A2.1 presents the influenza A virus matrix peptide 57-68 to cytotoxic T lymphocytes in all individuals with this common HLA type and is among the most thoroughly studied immune responses in humans. We have studied the T-cell receptor (TCR) heterogeneity of T cells specific for HLA-A2 and influenza A matrix peptide using the polymerase chain reaction. The usage of V alpha and V beta sequences seen on these T cells is remarkably conserved as are certain junctional sequences associated with alpha and beta chains. Furthermore, two unrelated HLA-A2 individuals have a similar pattern of TCR usage, implying that this is a predominant response in HLA-A2 populations. Analysis in one individual showed that the conserved TCR V alpha and V beta genes are minor members of the peripheral blood TCR repertoire. The sequences provide important information on the TCR necessary for the final structural analysis of this ternary complex.
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Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., & Wiley, D. C. (1987) · Nature · doi:10.1038/329512a0 · Cited by 2,377
Cited by
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Arstila, T. P., Casrouge, A., Baron, V., Even, J., Kanellopoulos, J., & Kourilsky, P. (1999) · Science · doi:10.1126/science.286.5441.958 · Cited by 931
Posnett, D. N., Sinha, R., Kabak, S., & Russo, C. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.2.609 · Cited by 760
Wills, M. R., Carmichael, A. J., Mynard, K., Jin, X., Weekes, M. P., Plachter, B., & Sissons, J. G. (1996) · Journal of Virology · doi:10.1128/jvi.70.11.7569-7579.1996 · Cited by 688
The molecular basis for public T-cell responses?
Venturi, V., Price, D. A., Douek, D. C., & Davenport, M. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2260 · Cited by 342
T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV Infection
Price, D. A., West, S. M., Betts, M. R., Ruff, L. E., Brenchley, J. M., Ambrozak, D. R., Edghill-Smith, Y., Kuroda, M. J., Bogdan, D., Kunstman, K., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.10.010 · Cited by 272
Metadata
- Authors
- Moss, P. A., Moots, R. J., Rosenberg, W. M., Rowland-Jones, S. J., Bodmer, H. C., McMichael, A. J., & Bell, J. I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-10-15
- Volume
- 88
- Issue
- 20
- Pages
- 8987-8990
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1988118551
- Cited by
- 282
- References
- 1
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. https://app.cochat.ai/papers/10.1073/pnas.88.20.8987
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- Moss, P. A., Moots, R. J., Rosenberg, W. M., Rowland-Jones, S. J., Bodmer, H. C., McMichael, A. J., & Bell, J. I. (1991). Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.20.8987
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