The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
A developmental switch in B lymphopoiesis.
Open accessAbstract
B and T lymphocytes are generated from hematopoietic stem cells during both fetal and adult life. A critical unresolved issue is whether the differentiation pathways in lymphopoiesis are the same in fetal and adult animals or whether they differ, similar to the hemoglobin switch in erythropoiesis. We report here that a developmental switch occurs in B lymphopoiesis. We isolated "pro-B" cells (i.e., cells that have initiated, but not completed, heavy-chain gene rearrangement) from fetal and adult sources and investigated their B-cell progeny generated both in vitro and in vivo. Most of the cells from fetal liver, but few from adult bone marrow, expressed CD5. Further, fetal pro-B cells failed to generate cells expressing high levels of IgD in severe combined immunodeficiency mice, whereas adult pro-B cells gave rise to CD5-B cells bearing IgD at levels comparable to the bulk of cells in the spleen of adult mice. Thus, all committed B progenitors in fetal liver of day 16 gestation mice give rise to phenotypically distinct progeny when compared to cells at a comparable differentiation stage in the bone marrow of adult animals. We conclude that the cohort of B-lineage progenitors in early fetal development is committed to a differentiation pathway distinct from that seen in the adult.
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Cites
A severe combined immunodeficiency mutation in the mouse
Bosma, G. C., Custer, R. P., & Bosma, M. J. (1983) · Nature · doi:10.1038/301527a0 · Cited by 2,207
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.
Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D., & Hayakawa, K. (1991) · The Journal of experimental medicine · doi:10.1084/jem.173.5.1213 · Cited by 1,601
Self-citationGoodnow, C. C., Crosbie, J., Adelstein, S., Lavoie, T. B., Smith-Gill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, R. H., Raphael, K., et al. (1988) · Nature · doi:10.1038/334676a0 · Cited by 1,565
Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
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The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice.
Hayakawa, K., Hardy, R. R., Parks, D. R., & Herzenberg, L. A. (1983) · The Journal of experimental medicine · doi:10.1084/jem.157.1.202 · Cited by 812
Self-citationLy-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies.
Hayakawa, K., Hardy, R. R., Honda, M., Herzenberg, L. A., Steinberg, A. D., & Herzenberg, L. A. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.8.2494 · Cited by 637
Self-citationProgenitors for Ly-1 B cells are distinct from progenitors for other B cells.
Hayakawa, K., Hardy, R. R., Herzenberg, L. A., & Herzenberg, L. A. (1985) · The Journal of experimental medicine · doi:10.1084/jem.161.6.1554 · Cited by 614
Self-citationIkuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y.-H., & Weissman, I. L. (1990) · Cell · doi:10.1016/0092-8674(90)90262-d · Cited by 583
Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors
Havran, W. L., & Allison, J. P. (1988) · Nature · doi:10.1038/335443a0 · Cited by 535
Cellular Mechanisms of Immunologic Tolerance
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Cited by
Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S.-I., Kitamura, Y., Yoshida, N., Kikutani, H., & Kishimoto, T. (1996) · Nature · doi:10.1038/382635a0 · Cited by 2,338
Hardy, R. R., & Hayakawa, K. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.595 · Cited by 1,235
Self-citationOrigins and Functions of B-1 Cells with Notes on the Role of CD5
Berland, R., & Wortis, H. H. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064833 · Cited by 745
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
Turner, M., Joseph Mee, P., Costello, P. S., Williams, O., Price, A. A., Duddy, L. P., Furlong, M. T., Geahlen, R. L., & Tybulewicz, V. L. J. (1995) · Nature · doi:10.1038/378298a0 · Cited by 612
The purification and characterization of fetal liver hematopoietic stem cells
Morrison, S. J., Hemmati, H. D., Wandycz, A. M., & Weissman, I. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10302 · Cited by 611
Metadata
- Authors
- Hardy, R. R., & Hayakawa, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-12-15
- Volume
- 88
- Issue
- 24
- Pages
- 11550-11554
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2059383814
- Cited by
- 268
- References
- 26
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- green
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