Cited by 583Hematopoietic Stem Cell TransplantationT-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

Open access
Ikuta, Koichi, Kina, Tatsuo, MacNeil, Ian, Uchida, Nobuko, Peault, Bruno, Chien, Yueh-hsiu, Weissman, Irving L.·1990·Cell

Abstract

Hematopoietic stem cells (HSCs) isolated from mouse fetal liver, like adult HSCs, are Thy-1lo Lin- Sca-1+. Donor-derived V gamma 3+ T cells were detected in fetal thymic lobes repopulated in vitro with fetal liver HSCs, but not in those with adult bone marrow HSCs. Single clonogenic fetal HSCs gave rise to thymic progeny that include V gamma 3+, other gamma delta+, and alpha beta+ T cells. No V gamma 3+ T cells were detected in adult thymus injected intrathymically with either fetal or adult HSCs. These results support the hypothesis that only fetal HSCs have the capacity to differentiate into V gamma 3+ T cells in the fetal thymic microenvironment and that the developmental potential of HSCs may change during ontogeny.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(90)90262-d

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The earliest fetal thymocytes are different from later waves of developing thymocytes in their abilities to generate particular classes of TCRγδ cells and in their extremely fast differentiation kinetics, both in vivo and in fetal thymic organ culture or stromal coculture systems.

    “It has long been recognized that the earliest fetal thymocytes are different from later waves of developing thymocytes in terms of their abilities to generate particular classes of TCRγδ cells (134) and in terms of their extremely fast differentiation kinetics, both in vivo and in fetal thymic organ culture or stromal coculture systems (104, 133, 135).”

Cites

Flagged first, then by citations

2 of the 51 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y.-H., & Weissman, I. L.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Kyoto University (JP)
  • Stanford Medicine (US)
Venue
Cell
Publisher
Elsevier BV
Published
1990-09
Volume
62
Issue
5
Pages
863-874
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2008661167
Cited by
583
References
51
Citations by year
2026: 2 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 7 · 2020: 17 · 2019: 10 · 2018: 5 · 2017: 9 · 2016: 10 · 2015: 10 · 2014: 9 · 2013: 11 · 2012: 15
FWCI
21.13
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r35ca042551-13)
  • National Cancer Institute (CA 42551)
  • National Institute of Allergy and Infectious Diseases (AI 09072)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
hematopoietic stem cells, fetal liver, γδ T cells, alpha beta T cells, fetal thymus, thymic microenvironment, ontogeny, developmental potential, Sca-1, CD90, clonogenic activity
MeSH terms
Animals, Antibodies, Monoclonal, Antigens, Differentiation, T-Lymphocyte, Base Sequence, Bone Marrow, Cell Differentiation, Cell Division, Colony-Forming Units Assay, Fetus, Flow Cytometry, Hematopoietic Stem Cells, Liver, Mice, Inbred C57BL, Molecular Sequence Data, Organ Culture Techniques, Phenotype, Poly A, Receptors, Antigen, T-Cell, RNA, Messenger, Spleen, T-Lymphocytes, Oligonucleotide Probes, Polymerase Chain Reaction, CD8 Antigens, CD3 Complex, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review