A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells
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Hematopoietic stem cells (HSCs) isolated from mouse fetal liver, like adult HSCs, are Thy-1lo Lin- Sca-1+. Donor-derived V gamma 3+ T cells were detected in fetal thymic lobes repopulated in vitro with fetal liver HSCs, but not in those with adult bone marrow HSCs. Single clonogenic fetal HSCs gave rise to thymic progeny that include V gamma 3+, other gamma delta+, and alpha beta+ T cells. No V gamma 3+ T cells were detected in adult thymus injected intrathymically with either fetal or adult HSCs. These results support the hypothesis that only fetal HSCs have the capacity to differentiate into V gamma 3+ T cells in the fetal thymic microenvironment and that the developmental potential of HSCs may change during ontogeny.
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The earliest fetal thymocytes are different from later waves of developing thymocytes in their abilities to generate particular classes of TCRγδ cells and in their extremely fast differentiation kinetics, both in vivo and in fetal thymic organ culture or stromal coculture systems.
“It has long been recognized that the earliest fetal thymocytes are different from later waves of developing thymocytes in terms of their abilities to generate particular classes of TCRγδ cells (134) and in terms of their extremely fast differentiation kinetics, both in vivo and in fetal thymic organ culture or stromal coculture systems (104, 133, 135).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [134]
Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719 · see citing works
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1
Till, J. E., & McCulloch, E. A. (2010) · Radiation Research · doi:10.1667/rrxx28.1 · Cited by 4,036 · see citing works
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
Till, J. E., & McCulloch, E. A. (1961) · Radiation Research · doi:10.2307/3570892 · Cited by 3,770 · see citing works
Purification and Characterization of Mouse Hematopoietic Stem Cells
Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,889 · see citing works
Self-citationA severe combined immunodeficiency mutation in the mouse
Bosma, G. C., Custer, R. P., & Bosma, M. J. (1983) · Nature · doi:10.1038/301527a0 · Cited by 2,223 · see citing works
Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*
Ledbetter, J. A., & Herzenberg, L. A. (1979) · Immunological Reviews · doi:10.1111/j.1600-065x.1979.tb00289.x · Cited by 1,937 · see citing works
Identification of a monoclonal antibody specific for a murine T3 polypeptide.
Léo, O., Foo, M., Sachs, D. H., Samelson, L. E., & Bluestone, J. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1374 · Cited by 1,596 · see citing works
Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody
Springer, T. A., Galfré, G., Secher, D. S., & Milstein, C. (1979) · European Journal of Immunology · doi:10.1002/eji.1830090410 · Cited by 1,108 · see citing works
Dialynas, D. P., Wilde, D. B., Marrack, P., Pierrès, A., Wall, K. A., Havran, W. L., Otten, G. R., Loken, M. R., Pierres, M., Kappler, J. W., et al. (1983) · Immunological Reviews · doi:10.1111/j.1600-065x.1983.tb01083.x · Cited by 1,014 · see citing works
Progenitors for Ly-1 B cells are distinct from progenitors for other B cells.
Hayakawa, K., Hardy, R. R., Herzenberg, L. A., & Herzenberg, L. A. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.161.6.1554 · Cited by 614 · see citing works
Herzenberg, L. A., Stall, A. M., Lalor, P. A., Sidman, C. L., Moore, W., Parks, D. R., & Herzenberg, L. A. (1986) · Immunological Reviews · doi:10.1111/j.1600-065x.1986.tb01503.x · Cited by 592 · see citing works
Lafaille, J. J., DeCloux, A., Bonneville, M., Takagaki, Y., & Tonegawa, S. (1989) · Cell · doi:10.1016/0092-8674(89)90609-0 · Cited by 565 · see citing works
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
Schüler, W., Weiler, I. J., Schuler, A., Phillips, R. A., Rosenberg, N. E., Mak, T. W., Kearney, J. F., Perry, R. P., & Bosma, M. J. (1986) · Cell · doi:10.1016/0092-8674(86)90695-1 · Cited by 545 · see citing works
Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors
Havran, W. L., & Allison, J. P. (1988) · Nature · doi:10.1038/335443a0 · Cited by 541 · see citing works
Limited diversity of γδ antigen receptor genes of thy-1+ dendritic epidermal cells
Asarnow, D. M., Kuziel, W. A., Bonyhad, M., Tigelaar, R. E., Tucker, P. W., & Allison, J. P. (1988) · Cell · doi:10.1016/0092-8674(88)90139-0 · Cited by 520 · see citing works
HODGSON, G. S., & Bradley, T. R. (1979) · Nature · doi:10.1038/281381a0 · Cited by 509 · see citing works
B220: a B cell-specific member of the T200 glycoprotein family
Coffman, R. L., & Weissman, I. L. (1981) · Nature · doi:10.1038/289681a0 · Cited by 506 · see citing works
Self-citationDifferentiation of normal and neoplastic hematopoietic cells
Clarkson, B. D., Marks, P. A., & Till, J. E. (1978) · Cold Spring Harbor Laboratory eBooks · Cited by 409 · see citing works
Diversity, rearrangement, and expression of murine T cell gamma genes
Garman, R. D., Doherty, P. J., & Raulet, D. H. (1986) · Cell · doi:10.1016/0092-8674(86)90787-7 · Cited by 403 · see citing works
Müller‐Sieburg, C. E., Whitlock, C. A., & Weissman, I. L. (1986) · Cell · doi:10.1016/0092-8674(86)90274-6 · Cited by 325 · see citing works
Self-citationThe adult T-cell receptor 5-chain is diverse and distinct from that of fetal thymocytes
Elliott, J. F., Rock, E. P., Patten, P. A., Davis, M. M., & Chien, Y. (1988) · Nature · doi:10.1038/331627a0 · Cited by 319 · see citing works
Self-citationIsolation of murine pluripotent hemopoietic stem cells.
Visser, J. W. M., Bauman, J. G. J., Mulder, A., Eliason, J. F., & Leeuw, A. M. D. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.159.6.1576 · Cited by 318 · see citing works
Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors
Havran, W. L., & Allison, J. P. (1990) · Nature · doi:10.1038/344068a0 · Cited by 317 · see citing works
Jenkinson, E. J., Franchi, L. L., Kingston, R., & Owen, J. J. T. (1982) · European Journal of Immunology · doi:10.1002/eji.1830120710 · Cited by 313 · see citing works
T-cell receptor δ gene rearrangements in early thymocytes
Chiei, Y.-H., Iwashima, M., Wettstein, D. A., Kaplan, K. B., Elliott, J. F., Born, W. K., & Davis, M. M. (1987) · Nature · doi:10.1038/330722a0 · Cited by 310 · see citing works
Cellular and developmental properties of fetal hematopoietic stem cells
Jordan, C. T., McKearn, J. P., & Lemischka, I. R. (1990) · Cell · doi:10.1016/0092-8674(90)90061-i · Cited by 303 · see citing works
Development and Physiology of LY‐1 B and its Human Homolog, LEU‐1 B
Hardy, R. R., & Hayakawa, K. (1986) · Immunological Reviews · doi:10.1111/j.1600-065x.1986.tb01502.x · Cited by 264 · see citing works
Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes
Havran, W. L., Poenie, M., Kimura, J., Tsien, R. Y., Weiss, A., & Allison, J. P. (1987) · Nature · doi:10.1038/330170a0 · Cited by 241 · see citing works
Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells
Asarnow, D. M., Goodman, T. G., Lefrançois, L., & Allison, J. P. (1989) · Nature · doi:10.1038/341060a0 · Cited by 214 · see citing works
Kingston, R., Jenkinson, E. J., & Owen, J. J. T. (1985) · Nature · doi:10.1038/317811a0 · Cited by 198 · see citing works
Ito, K., Bonneville, M., Takagaki, Y., Nakanishi, N., Kanagawa, O., Krecko, E. G., & Tonegawa, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.631 · Cited by 182 · see citing works
Enrichment of hematopoietic precursor cells and cloning of multipotential B-lymphocyte precursors.
McKearn, J. P., McCubrey, J. A., & Fagg, B. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.21.7414 · Cited by 169 · see citing works
Havran, W. L., Grell, S., Duwe, G., Kimura, J., Wilson, A., Kruisbeek, A. M., O’Brien, R. L., Born, W. K., Tigelaar, R. E., & Allison, J. P. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.11.4185 · Cited by 154 · see citing works
Globin Composition and Synthesis of Hemoglobins in Developing Fetal Mice Erythroid Cells
Fantoni, A., Bank, A., & Marks, P. A. (1967) · Science · doi:10.1126/science.157.3794.1327 · Cited by 154 · see citing works
Romani, N., Stingl, G., Tschachler, E., Witmer, M. D., Steinman, R. M., Shevach, E. M., & Schuler, G. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.161.6.1368 · Cited by 136 · see citing works
Lostrom, M. E., Stone, M. R., Tam, M. R., Burnette, W. N., Pinter, A., & Nowinski, R. C. (1979) · Virology · doi:10.1016/0042-6822(79)90557-9 · Cited by 128 · see citing works
Parks, D. R., & Herzenberg, L. A. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)08086-1 · Cited by 125 · see citing works
Thy-1+ dendritic epidermal cells belong to the T-cell lineage.
Stingl, G., Gunter, K. C., Tschachler, E., Yamada, H., Lechler, R. I., Yokoyama, W. M., Steiner, G. E., Germain, R. N., & Shevach, E. M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2430 · Cited by 109 · see citing works
Analysis of neoplasms induced by Cas-Br-M MuLV tumor extracts.
Holmes, K. L., Langdon, W. Y., Fredrickson, T. N., Coffman, R. L., Hoffman, P. M., Hartley, J. W., & Morse, H. C. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.2.679 · Cited by 101 · see citing works
Isolation of haemopoietic spleen colony forming cells.
Lord, B. I., & Spooncer, E. (1986) · PubMed · Cited by 75 · see citing works
Normal and Neoplastic Maturation of T-lineage LymphocytesPreprint
Weissman, I. L., Baird, S., Gardner, R. L., Papaioannou, V. E., & Raschke, W. C. (1977) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1977.041.01.005 · Cited by 65 · see citing works
Self-citationPillemer, E., Whitlock, C. A., & Weissman, I. L. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.14.4434 · Cited by 54 · see citing works
Self-citationA TCR Cell Recognizing a Novel TL-encoded Gene ProductPreprint
Houlden, B. A., Matis, L. A., Cron, R. Q., Widacki, S. M., Brown, G., Pampeno, C. L., Meruelo, D., & Bluestone, J. A. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.006 · Cited by 50 · see citing works
Adkins, B., Tidmarsh, G. F., & Weissman, I. L. (1988) · Immunogenetics · doi:10.1007/bf00346584 · Cited by 44 · see citing works
Self-citationStudies on the haemopoietic stem cells of mouse foetal liver
Silini, G., Pozzi, L., & Pons, S. (1967) · Development · doi:10.1242/dev.17.2.303 · Cited by 43 · see citing works
Sherwood, P. J., & Weissman, I. L. (1990) · International Immunology · doi:10.1093/intimm/2.5.399 · Cited by 41 · see citing works
Self-citationWatanabe, Y., Gyotoku, J.-I., & Katsura, Y. (1989) · PubMed · Cited by 16 · see citing works
Developmental Analysis of the Mouse Hematolymphoid SystemPreprint
Heimfeld, S., Guidos, C. J., Holzmann, B., Siegelman, M. H., & Weissman, I. L. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.010 · Cited by 7 · see citing works
Self-citationThe in vitro production of chimeric murine thymus from nonlymphoid embryonic precursors
Pyke, K. W., Bartlett, F. P., & MANDEL, T. E. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90279-x · Cited by 5 · see citing works
Flagged first, then by citations
2 of the 51 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253 · see citing works
Self-citationThe immune system evolved to discriminate infectious nonself from noninfectious self
Janeway, C. A. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90198-g · Cited by 1,343 · see citing works
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., & Mulligan, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90011-m · Cited by 1,281 · see citing works
Hardy, R. R., & Hayakawa, K. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.595 · Cited by 1,236 · see citing works
Cell intrinsic alterations underlie hematopoietic stem cell aging
Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · see citing works
Self-citationγδ Cells: A Right Time and a Right Place for a Conserved Third Way of Protection
Hayday, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.975 · Cited by 1,134 · see citing works
Morrison, S. J., & Weissman, I. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90037-x · Cited by 1,116 · see citing works
Self-citationRegulatory Mechanisms in Stem Cell Biology
Morrison, S. J., Shah, N. M., & Anderson, D. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81867-x · Cited by 1,040 · see citing works
Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application
Kondo, M., Wagers, A. J., Manz, M. G., Prohaska, S. S., Scherer, D. C., Beilhack, G. F., Shizuru, J. A., & Weissman, I. L. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141007 · Cited by 992 · see citing works
Self-citationVertebrate neural cell-fate determination: Lessons from the retina
Livesey, F. J., & Cepko, C. L. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053522 · Cited by 948 · see citing works
Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis
Neubauer, H. J., Cumano, A., Müller, M. M., Wu, H., Huffstadt, U., & Pfeffer, K. (1998) · Cell · doi:10.1016/s0092-8674(00)81168-x · Cited by 923 · see citing works
Stems Cells and the Pathways to Aging and Cancer
Rossi, D. J., Jamieson, C. H. M., & Weissman, I. L. (2008) · Cell · doi:10.1016/j.cell.2008.01.036 · Cited by 895 · see citing works
Self-citationGeneration of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
Nakano, T., Kodama, H., & Honjo, T. (1994) · Science · doi:10.1126/science.8066449 · Cited by 866 · see citing works
γδ T cells: functional plasticity and heterogeneity
Carding, S. R., & Egan, P. J. (2002) · Nature Reviews Immunology · doi:10.1038/nri797 · Cited by 814 · see citing works
Haas, W., Pereira, P., & Tonegawa, S. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.003225 · Cited by 808 · see citing works
No place like home: anatomy and function of the stem cell niche
Jones, D. L., & Wagers, A. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2319 · Cited by 794 · see citing works
Christensen, J. L., & Weissman, I. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261562798 · Cited by 786 · see citing works
Self-citationThe Biology of Hematopoietic Stem Cells
Morrison, S. J., Uchida, N., & Weissman, I. L. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.000343 · Cited by 774 · see citing works
Self-citationMorrison, S. J., White, P. M., Zock, C., & Anderson, D. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80583-8 · Cited by 749 · see citing works
Expression and function of c-kit in hemopoietic progenitor cells.
Ogawa, M., Matsuzaki, Y., Nishikawa, S., Hayashi, S., Kunisada, T., Sudo, T., Kina, T., Nakauchi, H., & Nishikawa, S. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.1.63 · Cited by 744 · see citing works
Self-citationJourney through the thymus: stromal guides for T-cell development and selection
Takahama, Y. (2006) · Nature reviews. Immunology · doi:10.1038/nri1781 · Cited by 730 · see citing works
Ineffective erythropoiesis in Stat5a−/−5b−/− mice due to decreased survival of early erythroblasts
Socolovsky, M., Nam, H.-S., Fleming, M. D., Haase, V. H., Brugnara, C., & Lodish, H. F. (2001) · Blood · doi:10.1182/blood.v98.12.3261 · Cited by 674 · see citing works
Ikuta, K., & Weissman, I. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1502 · Cited by 637 · see citing works
Self-citationThe purification and characterization of fetal liver hematopoietic stem cells
Morrison, S. J., Hemmati, H. D., Wandycz, A. M., & Weissman, I. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10302 · Cited by 611 · see citing works
Self-citationMechanisms of Stem Cell Self-Renewal
He, S., Nakada, D., & Morrison, S. J. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113248 · Cited by 644 · see citing works
The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
Warren, A. J., Colledge, W. H., Carlton, M. B. L., Evans, M. J., Smith, A. J. H., & Rabbitts, T. H. (1994) · Cell · doi:10.1016/0092-8674(94)90571-1 · Cited by 604 · see citing works
A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations
Matthews, W., Jordan, C. T., Wiegand, G. W., Pardoll, D., & Lemischka, I. R. (1991) · Cell · doi:10.1016/0092-8674(91)90010-v · Cited by 593 · see citing works
Han, H., Tanigaki, K., Yamamoto, N., Kuroda, K., Yoshimoto, M., Nakahata, T., Ikuta, K., & Honjo, T. (2002) · International Immunology · doi:10.1093/intimm/dxf030 · Cited by 587 · see citing works
Self-citationOrigin of Murine B Cell Lineages
Kantor, A. B., & Herzenberg, L. A. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.002441 · Cited by 578 · see citing works
Ws, A., Roberts, A. W., Nicola, N. A., Li, R., & Metcalf, D. (1996) · Blood · doi:10.1182/blood.v87.6.2162.bloodjournal8762162 · Cited by 576 · see citing works
Crane, G. M., Mosher, J. T., Bixby, S., Joseph, N. M., Iwashita, T., & Morrison, S. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00827-9 · Cited by 543 · see citing works
Itohara, S., Mombaerts, P., Lafaille, J. J., Iacomini, J., Nelson, A., Clarke, A. R., Hooper, M., Farr, A. G., & Tonegawa, S. (1993) · Cell · doi:10.1016/0092-8674(93)90112-4 · Cited by 526 · see citing works
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progressionPreprint
Baudino, T. A., McKay, C., Pendeville, H., Nilsson, J. A., Maclean, K. H., White, E. L., Davis, A. C., Ihle, J. N., & Cleveland, J. L. (2002) · Genes & Development · doi:10.1101/gad.1024602 · Cited by 516 · see citing works
Matthews, W., Jordan, C. T., Gavin, M. A., Jenkins, N. A., Copeland, N. G., & Lemischka, I. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9026 · Cited by 502 · see citing works
Georgopoulos, K., Moore, D. D., & Derfler, B. (1992) · Science · doi:10.1126/science.1439790 · Cited by 464 · see citing works
Early T Lymphocyte Progenitors
Shortman, K., & Wu, L. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.29 · Cited by 448 · see citing works
Transcription from the RAG1 Locus Marks the Earliest Lymphocyte Progenitors in Bone Marrow
Igarashi, H., Gregory, S. C., Yokota, T., Sakaguchi, N., & Kincade, P. W. (2002) · Immunity · doi:10.1016/s1074-7613(02)00366-7 · Cited by 452 · see citing works
Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans
Mold, J. E., Venkatasubrahmanyam, S., Burt, T. D., Michaëlsson, J., Rivera, J. M., Galkina, S. A., Weinberg, K., Stoddart, C. A., & McCune, J. M. (2010) · Science · doi:10.1126/science.1196509 · Cited by 444 · see citing works
The development of inducible bronchus-associated lymphoid tissue depends on IL-17
Rangel-Moreno, J., Carragher, D. M., de la Luz Garcia-Hernandez, M., Hwang, J. Y., Kusser, K., Hartson, L., Kolls, J. K., Khader, S. A., & Randall, T. D. (2011) · Nature Immunology · doi:10.1038/ni.2053 · Cited by 441 · see citing works
Kumaravelu, P., Hook, L., Morrison, A. M., Ure, J. M., Zhao, S., Zuyev, S., Ansell, J., & Medvinsky, A. (2002) · Development · doi:10.1242/dev.129.21.4891 · Cited by 435 · see citing works
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K., & Honjo, T. (2001) · Nature · doi:10.1038/35098100 · Cited by 430 · see citing works
Self-citationKim, I., Saunders, T. L., & Morrison, S. J. (2007) · Cell · doi:10.1016/j.cell.2007.06.011 · Cited by 426 · see citing works
Ontogeny-related changes in proliferative potential of human hematopoietic cells.
Lansdorp, P. M., Dragowska, W. H., & Mayani, H. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.3.787 · Cited by 384 · see citing works
Zhang, J., Socolovsky, M., Gross, A. W., & Lodish, H. F. (2003) · Blood · doi:10.1182/blood-2003-05-1479 · Cited by 386 · see citing works
SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis
Marine, J.-C., McKay, C., Wang, D., Topham, D. J., Parganas, E., Nakajima, H., Pendeville, H., Yasukawa, H., Sasaki, A., Yoshimura, A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80049-5 · Cited by 372 · see citing works
Uchida, N., & Weissman, I. L. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.1.175 · Cited by 359 · see citing works
Self-citationB-1 B Cell Development in the Fetus and Adult
Montecino‐Rodriguez, E., & Dorshkind, K. A. (2012) · Immunity · doi:10.1016/j.immuni.2011.11.017 · Cited by 353 · see citing works
Bcl11a is essential for normal lymphoid development
Liu, P., Keller, J. R., Ortiz, M., Tessarollo, L., Rachel, R. A., Nakamura, T., Jenkins, N. A., & Copeland, N. G. (2003) · Nature Immunology · doi:10.1038/ni925 · Cited by 351 · see citing works
Kina, T., Ikuta, K., Takayama, E., Wada, K., Sen-Majumdar, A., Weissman, I. L., & Katsura, Y. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02037.x · Cited by 350 · see citing works
Self-citationSchwartzberg, P. L., Stall, A. M., Hardin, J. D., Bowdish, K. S., Humaran, T. J., Boast, S., Harbison, M. L., Robertson, E. J., & Goff, S. P. (1991) · Cell · doi:10.1016/0092-8674(91)90012-n · Cited by 348 · see citing works
KUBOTA, H. Y., Avarbock, M. R., & Brinster, R. L. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.029207 · Cited by 343 · see citing works
Lin28b Reprograms Adult Bone Marrow Hematopoietic Progenitors to Mediate Fetal-Like Lymphopoiesis
Yuan, J., Nguyen, C. K., Liu, X., Kanellopoulou, C., & Muljo, S. A. (2012) · Science · doi:10.1126/science.1216557 · Cited by 343 · see citing works
The Immunobiology of T Cells with Invariant gammadelta Antigen Receptors
Allison, J. P., & Havran, W. L. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.003335 · Cited by 341 · see citing works
Requirement for p38α in Erythropoietin Expression
Tamura, K., SUDO, T., Senftleben, U., Dadak, A. M., Johnson, R. S., & Karin, M. (2000) · Cell · doi:10.1016/s0092-8674(00)00027-1 · Cited by 341 · see citing works
Shizuru, J. A., Negrin, R. S., & Weissman, I. L. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152334 · Cited by 337 · see citing works
Self-citationEnrichment and characterization of murine hematopoietic stem cells that express c-kit molecule
Okada, S., Nakauchi, H., Nagayoshi, K., Nishikawa, S.-I., Nishikawa, S.-I., Miura, Y., & Suda, T. (1991) · Blood · doi:10.1182/blood.v78.7.1706.1706 · Cited by 325 · see citing works
Thymic development of unconventional T cells: how NKT cells, MAIT cells and γδ T cells emerge
Pellicci, D. G., Koay, H., & Berzins, S. P. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0345-y · Cited by 329 · see citing works
Interleukin 7 receptor-deficient mice lack gammadelta T cells.
Maki, K., Sunaga, S., Komagata, Y., Kodaira, Y., Mabuchi, A., Karasuyama, H., Yokomuro, K., Miyazaki, J., & Ikuta, K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7172 · Cited by 319 · see citing works
Self-citationActivation events during thymic selection.
Bendelac, A. S., Matzinger, P., Seder, R. A., Paul, W. E., & Schwartz, R. H. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.3.731 · Cited by 319 · see citing works
Differential development of progenitor activity for three B-cell lineages.
Kantor, A. B., Stall, A. M., Adams, S. D., Herzenberg, L. A., & Herzenberg, L. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3320 · Cited by 314 · see citing works
Presence of hematopoietic stem cells in the adult liver
Taniguchi, H., Toyoshima, T., Fukao, K., & Nakauchi, H. (1996) · Nature Medicine · doi:10.1038/nm0296-198 · Cited by 312 · see citing works
Critical Role of the TIE2 Endothelial Cell Receptor in the Development of Definitive Hematopoiesis
Takakura, N., Huang, X.-L., Naruse, T., Hamaguchi, I., Dumont, D., Yancopoulos, G. D., & Suda, T. (1998) · Immunity · doi:10.1016/s1074-7613(00)80665-2 · Cited by 302 · see citing works
From hematopoiesis to neuropoiesis: Evidence of overlapping genetic programs
Terskikh, A. V., Easterday, M. C., Li, L., Hood, L., Kornblum, H. I., Geschwind, D. H., & Weissman, I. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131200898 · Cited by 288 · see citing works
Self-citationA developmental switch in B lymphopoiesis.
Hardy, R. R., & Hayakawa, K. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11550 · Cited by 268 · see citing works
The Protean Nature of Cells in the B Lymphocyte Lineage
Hardy, R. R., Kincade, P. W., & Dorshkind, K. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.013 · Cited by 267 · see citing works
Hematologic effects of flt3 ligand in vivo in mice
Brasel, K., McKenna, H. J., Morrissey, P. J., Charrier, K., Morris, A., Lee, C. C., Williams, D. E., & Lyman, S. D. (1996) · Blood · doi:10.1182/blood.v88.6.2004.bloodjournal8862004 · Cited by 260 · see citing works
Mebius, R. E., Streeter, P. R., Michie, S. A., Butcher, E. C., & Weissman, I. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.11019 · Cited by 250 · see citing works
Self-citationTsai, S., Bartelmez, S., Sitnicka, E., & Collins, S. J. (1994) · Genes & Development · doi:10.1101/gad.8.23.2831 · Cited by 250 · see citing works
Mebius, R. E., Miyamoto, T., Christensen, J. L., Domen, J., Cupedo, T., Weissman, I. L., & Akashi, K. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6593 · Cited by 241 · see citing works
Self-citationCD5 B Cells, a Fetal B Cell Lineage
Hardy, R. R., & Hayakawa, K. (1993) · Advances in immunology · doi:10.1016/s0065-2776(08)60512-x · Cited by 237 · see citing works
BMP signaling and stem cell regulation
Zhang, J., & Li, L. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.009 · Cited by 232 · see citing works
Estrogen deficiency stimulates B lymphopoiesis in mouse bone marrow.
Masuzawa, T., Miyaura, C., Onoe, Y., Kusano, K., Ohta, H., Nozawa, S., & Suda, T. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117424 · Cited by 227 · see citing works
Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire
Dimova, T., Brouwer, M., Gosselin, F., Tassignon, J., Léo, O., Donner, C., Marchant, A., & Vermijlen, D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412058112 · Cited by 241 · see citing works
Kawagoe, K., Kitamura, D., Okabe, M., Taniuchi, I., Ikawa, M., Watanabe, T., Kinoshita, T., & Takeda, J. (1996) · Blood · doi:10.1182/blood.v87.9.3600.bloodjournal8793600 · Cited by 225 · see citing works
Matsuzaki, Y., Gyotoku, J.-I., Ogawa, M., Nishikawa, S., Katsura, Y., Gachelin, G., & Nakauchi, H. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.4.1283 · Cited by 224 · see citing works
Non-genetic engineering of cells for drug delivery and cell-based therapy
Wang, Q., Cheng, H., Peng, H., Zhou, H., Li, P. Y., & Langer, R. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.12.003 · Cited by 225 · see citing works
Marques, A. H., O'Connor, T. G., Roth, C., Susser, E., & Bjørke-Monsen, A.-L. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00120 · Cited by 226 · see citing works
The Importation of Hematogenous Precursors by the Thymus Is a Gated Phenomenon in Normal Adult Mice
Foss, D. L., Donskoy, E., & Goldschneider, I. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.3.365 · Cited by 221 · see citing works
B Cell Development and Maturation
Wang, Y., Liu, J., Burrows, P. D., & Wang, J. O. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-3532-1_1 · Cited by 217 · see citing works
Forsberg, E. C., Serwold, T. F., Kogan, S. C., Weissman, I. L., & Passegue, E. A. (2006) · Cell · doi:10.1016/j.cell.2006.06.037 · Cited by 215 · see citing works
Self-citationThe bHLH gene Hes1 is essential for expansion of early T cell precursorsPreprint
Tomita, K., Hattori, M., Nakamura, E., Nakanishi, S., Minato, N., & Kageyama, R. (1999) · Genes & Development · doi:10.1101/gad.13.9.1203 · Cited by 209 · see citing works
Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors
Kim, I., He, S., Yilmaz, Ö. H., Kiel, M. J., & Morrison, S. J. (2006) · Blood · doi:10.1182/blood-2005-10-4135 · Cited by 201 · see citing works
Developmental Origin Governs CD8+ T Cell Fate Decisions during Infection
Smith, N. L., Patel, R. K., Reynaldi, A., Grenier, J. K., Wang, J., Watson, N. B., Nzingha, K., Mon, K. J. Y., Peng, S. A., Grimson, A., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.029 · Cited by 204 · see citing works
Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
Narayan, K., Sylvia, K., Malhotra, N., Yin, C., Martens, G. W., Vallerskog, T., Kornfeld, H., Xiong, N., Cohen, N. R., Brenner, M. B., et al. (2012) · Nature Immunology · doi:10.1038/ni.2247 · Cited by 199 · see citing works
Liu, C., Saito, F., Liu, Z., Lei, Y. L., Uehara, S., Love, P. E., Lipp, M., Kondo, S., Manley, N. R., & Takahama, Y. (2006) · Blood · doi:10.1182/blood-2006-05-024190 · Cited by 198 · see citing works
Immunoregulatory Functions of γδ T Cells
Born, W. K., Cady, C. T., Jones‐Carson, J., Mukasa, A., Lahn, M., & O’Brien, R. L. (1998) · Advances in immunology · doi:10.1016/s0065-2776(08)60400-9 · Cited by 196 · see citing works
Implantation and maintenance of functional human bone marrow in SCID-hu mice
Kyoizumi, S., Baum, C. M., Kaneshima, H., McCune, J. M., Yee, E. J., & Namikawa, R. (1992) · Blood · doi:10.1182/blood.v79.7.1704.1704 · Cited by 195 · see citing works
GATA‐1 but not SCL induces megakaryocytic differentiation in an early myeloid line.
Visvader, J. E., Elefanty, A. G., Strasser, A., & Adams, J. M. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05557.x · Cited by 189 · see citing works
A Transient Developmental Hematopoietic Stem Cell Gives Rise to Innate-like B and T Cells
Beaudin, A. E., Boyer, S. W., Perez-Cunningham, J., Hernandez, G. E., Derderian, S. C., Jujjavarapu, C., Aaserude, E., MacKenzie, T. C., & Forsberg, E. C. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.08.013 · Cited by 181 · see citing works
Antigen Markers of Macrophage Differentiation in Murine Tissues
Gordon, S., Lawson, L. J., Rabinowitz, S. S., Crocker, P. R., Morris, L., & Perry, V. H. (1992) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-77377-8_1 · Cited by 187 · see citing works
Roberts, N. A., White, A. J., Jenkinson, W. E., Turchinovich, G., Nakamura, K., Withers, D. R., McConnell, F. M., Desanti, G. E., Bénézech, C., Parnell, S. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.016 · Cited by 185 · see citing works
Characterization of mouse lymphohematopoietic stem cells lacking spleen colony-forming activity
Jones, R., Collector, M. I., Barber, J. P., Vala, M., Fackler, M., May, W. S., Griffin, C. A., Hawkins, A., Zehnbauer, B., Hilton, A., et al. (1996) · Blood · doi:10.1182/blood.v88.2.487.bloodjournal882487 · Cited by 185 · see citing works
Johns, J. L., & Christopher, M. M. (2012) · Veterinary Pathology · doi:10.1177/0300985811432344 · Cited by 180 · see citing works
Uchida, N., Aguila, H. L., Fleming, W., Jerabek, L., & Weissman, I. L. (1994) · Blood · doi:10.1182/blood.v83.12.3758.bloodjournal83123758 · Cited by 181 · see citing works
Self-citationAutonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence
Yoshimoto, M., Porayette, P., Glosson, N. L., Conway, S. J., Carlesso, N., Cardoso, A. A., Kaplan, M. H., & Yoder, M. C. (2012) · Blood · doi:10.1182/blood-2011-12-397489 · Cited by 178 · see citing works
Development and selection of γδ T cells
Xiong, N., & Raulet, D. H. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00478.x · Cited by 178 · see citing works
Qualitative and quantitative aspects of haematopoietic cell development in the mammalian embryo
Dzierzak, E. A., Medvinsky, A., & Bruijn, M. F. T. R. D. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)01258-4 · Cited by 177 · see citing works
Yokomizo, T., Ogawa, M., Osato, M., Kanno, T., Yoshida, H., Fujimoto, T., Fraser, S., Nishikawa, S., Okada, H., Satake, M., et al. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00393.x · Cited by 176 · see citing works
Hematopoietic Stem Cell Heterogeneity Takes Center Stage
Copley, M. R., Beer, P. A., & Eaves, C. J. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.006 · Cited by 174 · see citing works
Mechanisms of Fetal T Cell Tolerance and Immune Regulation
Rackaityte, E., & Halkias, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00588 · Cited by 171 · see citing works
- Authors
- Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y.-H., & Weissman, I. L.
- Affiliations
- Howard Hughes Medical Institute (US)
- Kyoto University (JP)
- Stanford Medicine (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1990-09
- Volume
- 62
- Issue
- 5
- Pages
- 863-874
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2008661167
- Cited by
- 583
- References
- 51
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 7 · 2020: 17 · 2019: 10 · 2018: 5 · 2017: 9 · 2016: 10 · 2015: 10 · 2014: 9 · 2013: 11 · 2012: 15
- FWCI
- 21.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r35ca042551-13)
- National Cancer Institute (CA 42551)
- National Institute of Allergy and Infectious Diseases (AI 09072)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- hematopoietic stem cells, fetal liver, γδ T cells, alpha beta T cells, fetal thymus, thymic microenvironment, ontogeny, developmental potential, Sca-1, CD90, clonogenic activity
- MeSH terms
- Animals, Antibodies, Monoclonal, Antigens, Differentiation, T-Lymphocyte, Base Sequence, Bone Marrow, Cell Differentiation, Cell Division, Colony-Forming Units Assay, Fetus, Flow Cytometry, Hematopoietic Stem Cells, Liver, Mice, Inbred C57BL, Molecular Sequence Data, Organ Culture Techniques, Phenotype, Poly A, Receptors, Antigen, T-Cell, RNA, Messenger, Spleen, T-Lymphocytes, Oligonucleotide Probes, Polymerase Chain Reaction, CD8 Antigens, CD3 Complex, Mice
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