The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Escherichia coli mfd mutant deficient in "mutation frequency decline" lacks strand-specific repair: in vitro complementation with purified coupling factor.
Open accessAbstract
Mutation frequency decline (MFD) is the rapid decrease in the frequency of certain induced nonsense suppressor mutations occurring when protein synthesis is transiently inhibited immediately after irradiation. MFD is abolished by mutations in the uvrA, -B, or -C genes, which prevent excision repair, or by a mfd mutation, which reduces the rate of excision but does not affect survival. Using an in vitro repair synthesis assay we found that although wild-type cells repair the transcribed (template) strand preferentially, mfd- cells are incapable of strand-specific repair. The deficiency in strand-selective repair of mfd- cell extract was corrected by adding highly purified "transcription-repair coupling factor" to the reaction mixture. We conclude that mfd is, most likely, the gene encoding the transcription-repair coupling factor.
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Citations
Cites
Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli
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Self-citationRadiation-Induced Mutations and Their Repair
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Self-citationTime, Temperature, and Protein Synthesis: A Study of Ultraviolet-Induced Mutation in BacteriaPreprint
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Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317
Self-citationWu, M., Sun, L. V., Vamathevan, J., Riegler, M., Deboy, R., Brownlie, J. C., McGraw, E. A., Martin, W., Esser, C., Ahmadinejad, N., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020069 · Cited by 851
“The only noteworthy DNA repair gene absent from w Mel and present in the more slowly evolving Rickettsia is mfd, which is involved in targeting DNA repair to the transcribed strand of actively transcribing genes in other species (Selby et al. 1991).”
Troelstra, C., van Gool, A., de Wit, J., Vermeulen, W., Bootsma, D., & Hoeijmakers, J. H. J. (1992) · Cell · doi:10.1016/0092-8674(92)90390-x · Cited by 729
Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions
Eisen, J. A., Sweder, K., & Hanawalt, P. C. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.14.2715 · Cited by 712
Molecular Mechanism of Transcription-Repair Coupling
Selby, C. P., & Sancar, A. (1993) · Science · doi:10.1126/science.8465200 · Cited by 656
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Metadata
- Authors
- Selby, C. P., Witkin, E. M., & Sancar, A.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- University of North Carolina at Chapel Hill (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1991-12-15
- Volume
- 88
- Issue
- 24
- Pages
- 11574-11578
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC53178
- OpenAlex
- W2153139649
- Cited by
- 215
- References
- 37
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 10 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 3 · 2014: 6 · 2013: 7 · 2012: 4
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM032833, GM32833)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- strand-specific repair, excision repair, DNA repair, Escherichia coli
- MeSH terms
- Alleles, Bacterial Proteins, Cell-Free System, DNA Repair, Escherichia coli, Genes, Bacterial, Genetic Complementation Test, Mutation, Phenotype, Plasmids, SOS Response, Genetics, Transcription Factors, Transcription, Genetic, Ultraviolet Rays, Genes, Suppressor, Mutagenesis
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