The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3.
Open accessAbstract
During early cardiac development, the progenitor cells of the heart valves and membranous septa undergo an epithelial-mesenchymal transformation. Previous studies have shown that this transformation depends on the activity of a transforming growth factor beta (TGF beta) molecule produced by the heart. In the present study, we have used modified antisense oligodeoxynucleotides generated to nonconserved regions of TGF beta 1, -2, -3, and -4 to examine the possible roles of these members in this transformation. A phosphoramidate-modified oligonucleotide complementary to TGF beta 3 mRNA was capable of inhibiting normal epithelial-mesenchymal transformation by 80%. Unmodified oligonucleotides to TGF beta 3, modified oligonucleotides to TGF beta 1, -2, and -4, and two modified control oligonucleotides were unable to inhibit the transformation. These data demonstrate that a specific member of the TGF beta family, TGF beta 3, is essential for the epithelial-mesenchymal cell transformation.
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Cites
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Cited by
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Early role of Fsp1 in epithelial-mesenchymal transformation
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Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis
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Metadata
- Authors
- Potts, J. D., Dagle, J. M., Walder, J. A., Weeks, D. L., & Runyan, R. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-02-15
- Volume
- 88
- Issue
- 4
- Pages
- 1516-1520
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1999686102
- Cited by
- 260
- References
- 20
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3. https://app.cochat.ai/papers/10.1073/pnas.88.4.1516
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- Potts, J. D., Dagle, J. M., Walder, J. A., Weeks, D. L., & Runyan, R. B. (1991). Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.4.1516
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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