The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel.
Open accessAbstract
The venom of the black mamba contains a 60-amino acid peptide called calciseptine. The peptide has been fully sequenced. It is a smooth muscle relaxant and an inhibitor of cardiac contractions. Its physiological action resembles that of drugs, such as the 1,4-dihydropyridines, which are important in the treatment of cardiovascular diseases. Calciseptine, like the 1,4-dihydropyridines, selectively blocks L-type Ca2+ channels and is totally inactive on other voltage-dependent Ca2+ channels such as N-type and T-type channels. To our knowledge, it is the only natural polypeptide that has been shown to be a specific inhibitor of L-type Ca2+ channels.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Multiple types of neuronal calcium channels and their selective modulation
Tsien, R. W., Lipscombe, D., Madison, D. V., Bley, K. R., & Fox, A. P. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90194-4 · Cited by 1,381
Cited by
Zamponi, G. W., Striessnig, J., Koschak, A., & Dolphin, A. C. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009654 · Cited by 1,103
Therapeutic potential of venom peptides
Lewis, R. J., & Garcia, M. L. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1197 · Cited by 798
Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury
Arundine, M., & Tymianski, M. (2004) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-003-3319-x · Cited by 647
Calcium Channels in the Development, Maturation, and Function of Spermatozoa
Darszon, A., Nishigaki, T., Beltran, C., & Treviño, C. L. (2011) · Physiological Reviews · doi:10.1152/physrev.00028.2010 · Cited by 364
Senji Laxme, R. R., Attarde, S., Khochare, S., Suranse, V., Martin, G., Casewell, N. R., Whitaker, R., & Sunagar, K. (2021) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0009150 · Cited by 101
Metadata
- Authors
- de Weille, J. R., Schweitz, H., Maes, P., Tartar, A., & Lazdunski, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-03-15
- Volume
- 88
- Issue
- 6
- Pages
- 2437-2440
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2118173900
- Cited by
- 232
- References
- 2
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel. https://app.cochat.ai/papers/10.1073/pnas.88.6.2437
- The paper
- de Weille, J. R., Schweitz, H., Maes, P., Tartar, A., & Lazdunski, M. (1991). Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.6.2437
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
