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Identification of intracellular receptor proteins for activated protein kinase C.
Open accessAbstract
Protein kinase C (PKC) translocates from the cytosol to the particulate fraction on activation. This activation-induced translocation of PKC is thought to reflect PKC binding to the membrane lipids. However, immunological and biochemical data suggest that PKC may bind to proteins in the cytoskeletal elements in the particulate fraction and in the nuclei. Here we describe evidence for the presence of intracellular receptor proteins that bind activated PKC. Several proteins from the detergent-insoluble material of the particulate fraction bound PKC in the presence of phosphatidylserine and calcium; binding was further increased with the addition of diacylglycerol. Binding of PKC to two of these proteins was concentration-dependent, saturable, and specific, suggesting that these binding proteins are receptors for activated C-kinase, termed here "RACKs." PKC binds to RACKs via a site on PKC distinct from the substrate binding site. We suggest that binding to RACKs may play a role in activation-induced translocation of PKC.
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Metadata
- Authors
- Mochly-Rosen, D., Khaner, H., & Lopez, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-05
- Volume
- 88
- Issue
- 9
- Pages
- 3997-4000
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1991714532
- Cited by
- 498
- References
- 0
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Mochly-Rosen, D., Khaner, H., & Lopez, J. (1991). Identification of intracellular receptor proteins for activated protein kinase C. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.9.3997
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