The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Toward rules relating zinc finger protein sequences and DNA binding site preferences.
Open accessAbstract
Zinc finger proteins of the Cys2-His2 type consist of tandem arrays of domains, where each domain appears to contact three adjacent base pairs of DNA through three key residues. We have designed and prepared a series of variants of the central zinc finger within the DNA binding domain of Sp1 by using information from an analysis of a large data base of zinc finger protein sequences. Through systematic variations at two of the three contact positions (underlined), relatively specific recognition of sequences of the form 5'-GGGGN(G or T)GGG-3' has been achieved. These results provide the basis for rules that may develop into a code that will allow the design of zinc finger proteins with preselected DNA site specificity.
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Cites
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
WATSON, J. D., & CRICK, F. H. C. (1953) · Nature · doi:10.1038/171737a0 · Cited by 13,584
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Boch, J., Scholze, H., Schornack, S., Landgraf, A., Hahn, S., Kay, S., Lahaye, T., Nickstadt, A., & Bonas, U. (2009) · Science · doi:10.1126/science.1178811 · Cited by 2,470
Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.
Kim, Y. G., Cha, J., & Chandrasegaran, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1156 · Cited by 1,889
DNA Recognition by Cys2His2 Zinc Finger Proteins
Wolfe, S. A., Nekludova, L., & Pabo, C. O. (2000) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.29.1.183 · Cited by 1,053
Genome-editing Technologies for Gene and Cell Therapy
Maeder, M. L., & Gersbach, C. A. (2016) · Molecular Therapy · doi:10.1038/mt.2016.10 · Cited by 719
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Metadata
- Authors
- Desjarlais, J. R., & Berg, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-08-15
- Volume
- 89
- Issue
- 16
- Pages
- 7345-7349
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2144177887
- Cited by
- 220
- References
- 1
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Desjarlais, J. R., & Berg, J. M. (1992). Toward rules relating zinc finger protein sequences and DNA binding site preferences. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.16.7345
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
