The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Magnetite biomineralization in the human brain.
Open accessAbstract
Although the mineral magnetite (Fe3O4) is precipitated biochemically by bacteria, protists, and a variety of animals, it has not been documented previously in human tissue. Using an ultrasensitive superconducting magnetometer in a clean-lab environment, we have detected the presence of ferromagnetic material in a variety of tissues from the human brain. Magnetic particle extracts from solubilized brain tissues examined with high-resolution transmission electron microscopy, electron diffraction, and elemental analyses identify minerals in the magnetite-maghemite family, with many of the crystal morphologies and structures resembling strongly those precipitated by magnetotactic bacteria and fish. These magnetic and high-resolution transmission electron microscopy measurements imply the presence of a minimum of 5 million single-domain crystals per gram for most tissues in the brain and greater than 100 million crystals per gram for pia and dura. Magnetic property data indicate the crystals are in clumps of between 50 and 100 particles. Biogenic magnetite in the human brain may account for high-field saturation effects observed in the T1 and T2 values of magnetic resonance imaging and, perhaps, for a variety of biological effects of low-frequency magnetic fields.
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Magnetic-Susceptibility Measurement of Human Iron Stores
Brittenham, G. M., Farrell, D. E., Harris, J. W., Feldman, E. S., Danish, E. H., Muir, W. A., Tripp, J. H., & Bellon, E. M. (1982) · New England Journal of Medicine · doi:10.1056/nejm198212303072703 · Cited by 367
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Oberdörster, G., Oberdörster, E., & Oberdörster, J. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7339 · Cited by 7,891
Imaging iron stores in the brain using magnetic resonance imaging
Haacke, E. M., Cheng, N. Y. C., House, M. J., Liu, Q., Neelavalli, J., Ogg, R. J., Khan, A., Ayaz, M., Kirsch, W., & Obenaus, A. (2005) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2004.10.001 · Cited by 995
Ordered ferrimagnetic form of ferrihydrite reveals links among structure, composition, and magnetism
Michel, F. M., Barrón, V., Torrent, J., Morales, M. P., Serna, C. J., Boily, J.-F., Liu, Q., Ambrosini, A., Cismasu, A. C., & Brown, G. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910170107 · Cited by 375
Metal Ions in Alzheimer’s Disease: A Key Role or Not?
Liu, Y., Nguyen, M., Robert, A., & Meunier, B. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00248 · Cited by 353
Raven, E. P., Lu, P. H., Tishler, T. A., Heydari, P., & Bartzokis, G. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130209 · Cited by 270
Metadata
- Authors
- Kirschvink, J. L., Kobayashi-Kirschvink, A., & Woodford, B. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-08-15
- Volume
- 89
- Issue
- 16
- Pages
- 7683-7687
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2004587610
- Cited by
- 614
- References
- 1
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Kirschvink, J. L., Kobayashi-Kirschvink, A., & Woodford, B. J. (1992). Magnetite biomineralization in the human brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.16.7683
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