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Emr, an Escherichia coli locus for multidrug resistance.
Open accessAbstract
An Escherichia coli chromosomal DNA fragment cloned on a multicopy plasmid conferred resistance to carbonylcyanide m-chlorophenylhydrazone, nalidixic acid, and a number of other toxic compounds. The sequence of the cloned emr locus located at minute 57.5 of the chromosome revealed two open reading frames, emrA and emrB. emrB encodes a highly hydrophobic 56.2-kDa peptide, with 14 potential alpha-helices to span the inner membrane. The peptide is homologous to QacA, a multidrug-resistant pump from Staphylococcus aureus, and belongs to a gene family that includes tetracycline-resistant pumps of Gram-positive bacteria and the galactose/H+ symporter of E. coli. emrA encodes a putative 42.7-kDa peptide containing a single hydrophobic domain and a large C-terminal hydrophilic domain. An active pho-fusion to the C domain suggested that EmrA is a membrane protein. Disruption of emrB significantly increased sensitivity of cells to uncouplers. The cellular content of uncoupler increased in the order: overexpressed emrB cells greater than wild type greater than emrB-.
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Cited by
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Sikkema, J., de Bont, J. A., & Poolman, B. (1995) · Microbiological Reviews · doi:10.1128/mr.59.2.201-222.1995 · Cited by 2,685
“coli (184), of 29,79-bis-(2-carboxyethyl)-5(and -6)-carboxyfluorescein by Lactococcus lactis (207), and of various P-glycoprotein substrates such as ethidium bromide, daunomycin, chloroquine, rhodamine 6G, gramicidin, and nigericin by L.”
BackgroundPrevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux
Nikaido, H. (1994) · Science · doi:10.1126/science.8153625 · Cited by 1,540
Multidrug efflux pumps of gram-negative bacteria
Nikaido, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.20.5853-5859.1996 · Cited by 1,082
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van de Guchte, M., Serror, P., Chervaux, C., Smokvina, T., Ehrlich, S. D., & Maguin, E. (2002) · Antonie van Leeuwenhoek · doi:10.1023/a:1020631532202 · Cited by 648
Metadata
- Authors
- Lomovskaya, O., & Lewis, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-10
- Volume
- 89
- Issue
- 19
- Pages
- 8938-8942
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2069031486
- Cited by
- 424
- References
- 0
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- green
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