The DOI matches its Crossref record.
Peptoids: a modular approach to drug discovery.
Open accessAbstract
Peptoids, oligomers of N-substituted glycines, are described as a motif for the generation of chemically diverse libraries of novel molecules. Ramachandran-type plots were calculated and indicate a greater diversity of conformational states available for peptoids than for peptides. The monomers incorporate t-butyl-based side-chain and 9-fluorenylmethoxy-carbonyl alpha-amine protection. The controlled oligomerization of the peptoid monomers was performed manually and robotically with in situ activation by either benzotriazol-1-yloxytris(pyrrolidino)phosphonium hexafluorophosphate or bromotris(pyrrolidino)phosphonium hexaflurophosphate. Other steps were identical to peptide synthesis using alpha-(9-fluorenylmethoxycarbonyl)amino acids. A total of 15 monomers and 10 oligomers (peptoids) are described. Preliminary data are presented on the stability of a representative oligopeptoid to enzymatic hydrolysis. Peptoid versions of peptide ligands of three biological systems (bovine pancreatic alpha-amylase, hepatitis A virus 3C proteinase, and human immunodeficiency virus transactivator-responsive element RNA) were found with affinities comparable to those of the corresponding peptides. The potential use of libraries of these compounds in receptor- or enzyme-based assays is discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Free-floating ultrathin two-dimensional crystals from sequence-specific peptoid polymers
Nam, K. T., Shelby, S. A., Choi, P. H., Marciel, A. B., Chen, R., Tan, L., Chu, T. K., Mesch, R. A., Lee, B.-C., Connolly, M. D., et al. (2010) · Nature Materials · doi:10.1038/nmat2742 · Cited by 417
Self-citationThe combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library.
Bunin, B. A., Plunkett, M. J., & Ellman, J. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4708 · Cited by 260
Surface-grafted polysarcosine as a peptoid antifouling polymer brush
Lau, K. H. A., Ren, C., Sileika, T. S., Park, S. H., Szleifer, I., & Messersmith, P. B. (2012) · Langmuir · doi:10.1021/la302131n · Cited by 178
London, N., Raveh, B., Movshovitz‐Attias, D., & Schueler‐Furman, O. (2010) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.22785 · Cited by 164
Aβ40 Oligomers Identified as a Potential Biomarker for the Diagnosis of Alzheimer's Disease
Gao, C. M., Yam, A. Y., Wang, X., Magdangal, E., Salisbury, C., Peretz, D., Zuckermann, R. N., Connolly, M. D., Hansson, O., Minthon, L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015725 · Cited by 105
“ASR1 is a peptoid, a peptidomimetic containing N-substituted glycines [26], which have been shown to be resistant to proteolytic digestion from enzymes commonly found in body fluids [27].”
Background
Metadata
- Authors
- Simon, R. J., Kania, R. S., Zuckermann, R. N., Huebner, V. D., Jewell, D. A., Banville, S., Ng, S., Wang, L., Rosenberg, S., & Marlowe, C. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-10-15
- Volume
- 89
- Issue
- 20
- Pages
- 9367-9371
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2142759234
- Cited by
- 953
- References
- 0
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Peptoids: a modular approach to drug discovery. https://app.cochat.ai/papers/10.1073/pnas.89.20.9367
- The paper
- Simon, R. J., Kania, R. S., Zuckermann, R. N., Huebner, V. D., Jewell, D. A., Banville, S., Ng, S., Wang, L., Rosenberg, S., & Marlowe, C. K. (1992). Peptoids: a modular approach to drug discovery. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.20.9367
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
