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A conserved double-stranded RNA-binding domain.
Open accessAbstract
We have identified a double-stranded (ds)RNA-binding domain in each of two proteins: the product of the Drosophila gene staufen, which is required for the localization of maternal mRNAs, and a protein of unknown function, Xlrbpa, from Xenopus. The amino acid sequences of the binding domains are similar to each other and to additional domains in each protein. Database searches identified similar domains in several other proteins known or thought to bind dsRNA, including human dsRNA-activated inhibitor (DAI), human trans-activating region (TAR)-binding protein, and Escherichia coli RNase III. By analyzing in detail one domain in staufen and one in Xlrbpa, we delimited the minimal region that binds dsRNA. On the basis of the binding studies and computer analysis, we have derived a consensus sequence that defines a 65- to 68-amino acid dsRNA-binding domain.
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Cites
Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
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Williams, B. R. (1999) · Oncogene · doi:10.1038/sj.onc.1203127 · Cited by 820
RNA LOCALIZATION IN DEVELOPMENT
Bashirullah, A., Cooperstock, R. L., & Lipshitz, H. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.335 · Cited by 339
RED2, a Brain-specific Member of the RNA-specific Adenosine Deaminase Family
Melcher, T., Maas, S., Herb, A., Sprengel, R., Higuchi, M., & Seeburg, P. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.31795 · Cited by 295
Hiraguri, A., Itoh, R., Kondo, N., Nomura, Y., Aizawa, D., Murai, Y., Koiwa, H., Seki, M., Shinozaki, K., & Fukuhara, T. (2005) · Plant Molecular Biology · doi:10.1007/s11103-004-6853-5 · Cited by 295
Metadata
- Authors
- St Johnston, D., Brown, N. H., Gall, J. G., & Jantsch, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-11-15
- Volume
- 89
- Issue
- 22
- Pages
- 10979-10983
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2128674562
- Cited by
- 537
- References
- 1
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- green
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- St Johnston, D., Brown, N. H., Gall, J. G., & Jantsch, M. (1992). A conserved double-stranded RNA-binding domain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.22.10979
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