The DOI matches its Crossref record; 188 of the 188 references it cites were found in a registry or an index.
RNA LOCALIZATION IN DEVELOPMENT
Abstract
Cytoplasmic RNA localization is an evolutionarily ancient mechanism for producing cellular asymmetries. This review considers RNA localization in the context of animal development. Both mRNAs and non-protein-coding RNAs are localized in Drosophila, Xenopus, ascidian, zebrafish, and echinoderm oocytes and embryos, as well as in a variety of developing and differentiated polarized cells from yeast to mammals. Mechanisms used to transport and anchor RNAs in the cytoplasm include vectorial transport out of the nucleus, directed cytoplasmic transport in association with the cytoskeleton, and local entrapment at particular cytoplasmic sites. The majority of localized RNAs are targeted to particular cytoplasmic regions by cis-acting RNA elements; in mRNAs these are almost always in the 3′-untranslated region (UTR). A variety of trans-acting factors—many of them RNA-binding proteins—function in localization. Developmental functions of RNA localization have been defined in Xenopus, Drosophila, and Saccharomyces cerevisiae. In Drosophila, localized RNAs program the antero-posterior and dorso-ventral axes of the oocyte and embryo. In Xenopus, localized RNAs may function in mesoderm induction as well as in dorso-ventral axis specification. Localized RNAs also program asymmetric cell fates during Drosophila neurogenesis and yeast budding.
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Cites
Dumont, J. N. (1972) · Journal of Morphology · doi:10.1002/jmor.1051360203 · Cited by 1,849
MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function
Iozzo, R. V. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.609 · Cited by 1,637
Ovarian development in Drosophila melanogaster
King, R. C. (1970) · Medical Entomology and Zoology · Cited by 1,405
Topographic organization of sensory projections to the olfactory bulb
Vassar, R., Chao, S. K., Sitcheran, R., Nun˜ez, J. M., Vosshall, L. B., & Axel, R. (1994) · Cell · doi:10.1016/0092-8674(94)90029-9 · Cited by 1,295
Ressler, K. J., Sullivan, S. L., & Buck, L. B. (1994) · Cell · doi:10.1016/0092-8674(94)90015-9 · Cited by 1,211
Requirement for Xist in X chromosome inactivation
Penny, G. D., Kay, G. F., Sheardown, S. A., Rastan, S., & Brockdorff, N. (1996) · Nature · doi:10.1038/379131a0 · Cited by 1,205
Foe, V. E., & Alberts, B. M. (1983) · Journal of Cell Science · doi:10.1242/jcs.61.1.31 · Cited by 1,049
The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner
Driever, W., & Nüsslein-Volhard, C. (1988) · Cell · doi:10.1016/0092-8674(88)90183-3 · Cited by 1,029
A gradient of bicoid protein in Drosophila embryos
Driever, W., & Nüsslein-Volhard, C. (1988) · Cell · doi:10.1016/0092-8674(88)90182-1 · Cited by 1,017
Requirement for Xist in X chromosome inactivation
(1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81414-4 · Cited by 970
Cited by
Lécuyer, E., Yoshida, H., Parthasarathy, N., Alm, C., Babak, T., Cerovina, T., Hughes, T. R., Tomancak, P., & Krause, H. M. (2007) · Cell · doi:10.1016/j.cell.2007.08.003 · Cited by 967
The RNA‐binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticity
Deschênes‐Furry, J., Perrone‐Bizzozero, N., & Jasmin, B. J. (2006) · BioEssays · doi:10.1002/bies.20449 · Cited by 93
Global analyses of mRNA translational control during early Drosophila embryogenesis
Qin, X., Ahn, S., Speed, T. P., & Rubin, G. M. (2007) · Genome Biology · doi:10.1186/gb-2007-8-4-r63 · Cited by 86
Metadata
- Authors
- Bashirullah, A., Cooperstock, R. L., & Lipshitz, H. D.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1998-06
- Volume
- 67
- Issue
- 1
- Pages
- 335-394
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2097617128
- Cited by
- 339
- References
- 188
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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