mRNA localization: Gene expression in the spatial dimension
Open accessAbstract
The localization of mRNAs to subcellular compartments provides a mechanism for regulating gene expression with exquisite temporal and spatial control. Recent studies suggest that a large fraction of mRNAs localize to distinct cytoplasmic domains. In this Review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the assembly of mRNAs into granules that are transported by molecular motors along cytoskeletal elements to their final destination in the cell.
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A 3′UTR participates in alternative cleavage and polyadenylation, translation, and localization of mRNA, affecting mRNA stability.
“A 3′UTR participates in such processes as alternative cleavage and polyadenylation, translation, and localization of mRNA [19], affecting mRNA stability [20].”
From Effects of Combinations of Untranslated-Region Sequences on Translation of mRNA (2023) · cites this paper as [19]
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“Internal base editing and splicing guarantee the exclusive continu-ance of coding sections, while distinct modifications at the 5´ and 3´ untranslated regions (UTR) ensure mRNA stability and correct subcellular localization [16].”
- Authors
- Martin, K. C., & Ephrussi, A.
- Affiliations
- University of California, Los Angeles (US)
- European Molecular Biology Laboratory (DE)
- Corresponding author
- Martin, Kelsey C.
- Ephrussi, Anne
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 136
- Issue
- 4
- Pages
- 719-730
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2819924
- OpenAlex
- W1970827552
- Cited by
- 1,048
- References
- 0
- Citations by year
- 2026: 36 · 2025: 39 · 2024: 55 · 2023: 66 · 2022: 40 · 2021: 83 · 2020: 56 · 2019: 63 · 2018: 67 · 2017: 73 · 2016: 62 · 2015: 37 · 2014: 77 · 2013: 67 · 2012: 62
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS045324)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Biotin and Related Studies
- Keywords
- mRNA localization, RNA-binding proteins, RNA granules, molecular motors, cytoskeleton, subcellular compartmentalization, spatial regulation of gene expression, mRNA transport
- MeSH terms
- Animals, Cytoplasm, Humans, RNA, Messenger, RNA-Binding Proteins, RNA Transport, Regulatory Sequences, Ribonucleic Acid
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