The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis.
Open accessAbstract
Estradiol is known to exert a protective effect against the development of atherosclerosis, but the mechanism of this hormonal action is unknown. One of the early events in the development of atherosclerosis is the adhesion of macrophages to endothelial cells, and nitric oxide (NO) inhibits this process. We show that basal release of NO is greater with endothelium-intact aortic rings from female rabbits than those from males. Oophorectomy diminishes both circulating estradiol concentration and basal release of NO to levels seen in male rabbits. These data establish that basal NO release from endothelium-intact aortic rings depends on circulating estradiol concentration and offer an explanation for the protective effect of estradiol against the development of atherosclerosis.
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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
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Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
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Self-citationVascular endothelial cells synthesize nitric oxide from L-arginine
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Self-citationENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM
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Cited by
Androgens and Coronary Artery Disease
Wu, F. C. W., & von Eckardstein, A. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0025 · Cited by 592
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Estrogen as a Neuroprotectant in Stroke
Hurn, P. D., & Macrae, I. M. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200004000-00001 · Cited by 401
Metadata
- Authors
- Hayashi, T., Fukuto, J. M., Ignarro, L. J., & Chaudhuri, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-12
- Volume
- 89
- Issue
- 23
- Pages
- 11259-11263
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978001365
- Cited by
- 469
- References
- 38
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. https://app.cochat.ai/papers/10.1073/pnas.89.23.11259
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- Hayashi, T., Fukuto, J. M., Ignarro, L. J., & Chaudhuri, G. (1992). Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.23.11259
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
