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Cited by 416

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Role of the alpha v beta 3 integrin in human melanoma cell invasion.

Open access
Seftor, R E, Seftor, E A, Gehlsen, K R, Stetler-Stevenson, W G, Brown, P D, Ruoslahti, E, Hendrix, M J·1992·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.89.5.1557
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Abstract

The human melanoma cell line A375M expresses the vitronectin receptor (alpha v beta 3 integrin) on its cell surface. Treatment of A375M cells with either polyclonal or monoclonal anti-alpha v beta 3 antibodies resulted in stimulation of invasion through basement membrane matrices in vitro. Similar treatment of these cells with a monoclonal anti-alpha v antibody, which does not inhibit the adhesive function of the alpha v beta 3 antigen, also stimulated invasion; however, anti-beta 3 antibody treatment had no effect. Furthermore, pretreatment of the cells with vitronectin or addition of vitronectin to the basement membrane matrix also resulted in stimulation of invasion. Similar treatments with fibronectin receptor antibody or fibronectin had no effect on invasion. Analysis of type IV collagenase expression in cells treated with anti-alpha v beta 3 antibody showed higher levels of both the secreted 72-kDa enzyme and its mRNA. Signal transduction through the alpha v beta 3 integrin could underlie the elevated expression of metalloproteinase and the enhanced invasion of A375M cells through basement membrane matrices.

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Crossref · 10.1073/pnas.89.5.1557

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Metadata

Authors
Seftor, R. E., Seftor, E. A., Gehlsen, K. R., Stetler-Stevenson, W. G., Brown, P. D., Ruoslahti, E., & Hendrix, M. J.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1992-03
Volume
89
Issue
5
Pages
1557-1561
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.89.5.1557
OpenAlex
W2046690431
Cited by
416
References
38
FWCI
9.15
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Role of the alpha v beta 3 integrin in human melanoma cell invasion. https://app.cochat.ai/papers/10.1073/pnas.89.5.1557
The paper
Seftor, R. E., Seftor, E. A., Gehlsen, K. R., Stetler-Stevenson, W. G., Brown, P. D., Ruoslahti, E., & Hendrix, M. J. (1992). Role of the alpha v beta 3 integrin in human melanoma cell invasion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.5.1557

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.