The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.
Open accessAbstract
Chromosome translocations involving band 11q23 are associated with human acute leukemias. These translocations fuse the ALL-1 gene, homolog of Drosophila trithorax and located at chromosome band 11q23, to genes from a variety of chromosomes. We cloned and sequenced cDNAs derived from transcripts of the AF-4 and AF-9 genes involved in the most common chromosome abnormalities, t(4:11)(q21:q23) and t(9:11)(p22:q23), respectively. Sequence analysis indicates high homology between the AF-9 gene protein product and the protein encoded by the ENL gene fused to ALL-1 in (11:19) chromosome translocations. AF-4, AF-9, and ENL proteins contain nuclear targeting sequences as well as serine-rich and proline-rich regions. Stretches abundant in basic amino acids are also present in the three proteins. These results suggest that the different proteins fused to ALL-1 polypeptide(s) provide similar functional domains.
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An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene
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Metadata
- Authors
- Nakamura, T., Alder, H., Gu, Y., Prasad, R., Canaani, O., Kamada, N., Gale, R. P., Lange, B., Crist, W. M., & Nowell, P. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-05-15
- Volume
- 90
- Issue
- 10
- Pages
- 4631-4635
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2036296056
- Cited by
- 278
- References
- 15
- FWCI
- 38.35
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. https://app.cochat.ai/papers/10.1073/pnas.90.10.4631
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- Nakamura, T., Alder, H., Gu, Y., Prasad, R., Canaani, O., Kamada, N., Gale, R. P., Lange, B., Crist, W. M., & Nowell, P. C. (1993). Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.10.4631
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