The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene
Abstract
The human ELL gene on chromosome 19 undergoes frequent translocations with the trithorax -like MLL gene on chromosome 11 in acute myeloid leukemias. Here, ELL was shown to encode a previously uncharacterized elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. Functionally, ELL resembles Elongin (SIII), a transcription elongation factor regulated by the product of the von Hippel-Lindau ( VHL ) tumor suppressor gene. The discovery of a second elongation factor implicated in oncogenesis provides further support for a close connection between the regulation of transcription elongation and cell growth.
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Cites
Chromosomal translocations in human cancer
Rabbitts, T. H. (1994) · Nature · doi:10.1038/372143a0 · Cited by 1,503
Tkachuk, D. C., Kohler, S., & Cleary, M. L. (1992) · Cell · doi:10.1016/0092-8674(92)90602-9 · Cited by 920
Gu, Y., Nakamura, T., Alder, H., Prasad, R., Canaani, O., Cimino, G., Croce, C. M., & Canaani, E. (1992) · Cell · doi:10.1016/0092-8674(92)90603-a · Cited by 824
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C
Kibel, A., Iliopoulos, O., DeCaprio, J. A., & Kaelin, W. G. (1995) · Science · doi:10.1126/science.7660130 · Cited by 671
Chromosome Aberrations and Cancer
Solomon, E., Borrow, J., & Goddard, A. D. (1991) · Science · doi:10.1126/science.1957167 · Cited by 584
Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein
Duan, D. R., Pause, A., Burgess, W. H., Aso, T., Chen, D. Y. T., Garrett, K. P., Conaway, R. C., Conaway, J. W., Linehan, W. M., & Klausner, R. D. (1995) · Science · doi:10.1126/science.7660122 · Cited by 568
Self-citationMarshall, N. F., & Price, D. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.21.12335 · Cited by 560
Elongin (SIII): A Multisubunit Regulator of Elongation by RNA Polymerase II
Aso, T., Lane, W. S., Conaway, J. W., & Conaway, R. C. (1995) · Science · doi:10.1126/science.7660129 · Cited by 331
Self-citationNakamura, T., Alder, H., Gu, Y., Prasad, R., Canaani, O., Kamada, N., Gale, R. P., Lange, B., Crist, W. M., & Nowell, P. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4631 · Cited by 278
Prasad, R., Gu, Y., Alder, H., Nakamura, T., Canaani, O. D., Saito, H., Huebner, K., Gale, R. P., Nowell̀, P. C., & Kuriyama, K. (1993) · PubMed · Cited by 257
Cited by
MLL translocations, histone modifications and leukaemia stem-cell development
Krivtsov, A. V., & Armstrong, S. A. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2253 · Cited by 1,249
Shilatifard, A. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051710-134100 · Cited by 1,091
Self-citationElongation by RNA polymerase II: the short and long of it
Sims, R. J., Belotserkovskaya, R., & Reinberg, D. (2004) · Genes & Development · doi:10.1101/gad.1235904 · Cited by 709
Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro
Zhu, Y., Pe’ery, T., Peng, J., Ramanathan, Y., Marshall, N., Marshall, T., Amendt, B., Mathews, M. B., & Price, D. H. (1997) · Genes & Development · doi:10.1101/gad.11.20.2622 · Cited by 696
Lin, C., Smith, E. R., Takahashi, H., Lai, K. C., Martin-Brown, S., Florens, L., Washburn, M. P., Conaway, J. W., Conaway, R. C., & Shilatifard, A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.026 · Cited by 573
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Metadata
- Authors
- Shilatifard, A., Lane, W. S., Jackson, K. W., Conaway, R. C., & Conaway, J. W.
- Venue
- Science
- Published
- 1996-03-29
- Volume
- 271
- Issue
- 5257
- Pages
- 1873-1876
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043220867
- Cited by
- 324
- References
- 22
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene. https://app.cochat.ai/papers/10.1126/science.271.5257.1873
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- Shilatifard, A., Lane, W. S., Jackson, K. W., Conaway, R. C., & Conaway, J. W. (1996). An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene. Science. https://doi.org/10.1126/science.271.5257.1873
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
