The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor.
Open accessAbstract
The nitric oxide synthase inhibitor NG-nitro-L-arginine (NO2Arg) blocks morphine tolerance in mice. After implantation of morphine pellets the analgesic response decreases from 100% on the first day to 0% on the third. Coadministration of NO2Arg along with the pellets markedly retards the development of tolerance; 60% of mice are analgesic after 3 days, and 50% of mice are analgesic after 5 days. In a daily injection paradigm the analgesic response to morphine is reduced from 60% to 0% by 5 days. Concomitant administration of morphine along with NO2Arg at doses of 2 mg/kg per day prevents tolerance for 4 weeks. A single NO2Arg dose retards morphine tolerance for several days, and dosing every 4 days is almost as effective as daily NO2Arg. NO2Arg slowly reverses preexisting tolerance over 5 days despite the continued administration of morphine along with NO2Arg. NO2Arg also reduces dependence and reverses previously established dependence. NO2Arg does not prevent tolerance to analgesia mediated by the kappa 1 agonist trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolindinyl)cyclohexyl]- benzene-acetamide (U50,488H) or the kappa 3 agent naloxone benzoylhydrazone, indicating a selective action of NO in the mechanisms of mu tolerance and dependence.
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Citations
Cites
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Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages
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Nitric oxide, a novel neuronal messenger
Bredt, D. S., & Snyder, S. H. (1992) · Neuron · doi:10.1016/0896-6273(92)90104-l · Cited by 1,846
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Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801
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Sharma, S. K., Klee, W. A., & Nirenberg, M. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.8.3092 · Cited by 665
Nitric oxide as a neuronal messenger
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Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia
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Self-citation
Cited by
Gases as biological messengers: nitric oxide and carbon monoxide in the brain
Dawson, T., & Snyder, S. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05147.1994 · Cited by 1,043
Mechanisms of hyperalgesian and morphine tolerance: a current view of their possible interactions
Mao, J., Price, D. D., & Mayer, D. J. (1995) · Pain · doi:10.1016/0304-3959(95)00073-2 · Cited by 818
Mu Opioids and Their Receptors: Evolution of a Concept
Pasternak, G. W., & Pan, Y.-X. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007138 · Cited by 578
Self-citationNitric Oxide: A Neural Messenger
Jaffrey, S. R., & Snyder, S. H. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.002221 · Cited by 349
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Metadata
- Authors
- Kolesnikov, Y. A., Pick, C. G., Ciszewska, G., & Pasternak, G. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-06
- Volume
- 90
- Issue
- 11
- Pages
- 5162-5166
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1979768960
- Cited by
- 275
- References
- 28
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Kolesnikov, Y. A., Pick, C. G., Ciszewska, G., & Pasternak, G. W. (1993). Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.11.5162
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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