The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia
Abstract
The endogenous neuropeptide cholecystokinin, when administered systemically or perispinally, potently antagonizes opiate analgesia produced by foot shock and morphine. Nonopiate foot-shock analgesia is not reduced by this neuropeptide. The spinal cord appears to be a critical site of cholecystokinin action. These experiments suggest a physiological role for cholecystokinin as a specific opiate antagonist in analgesia-mediating systems. A similar mode of action may explain other behavioral effects of cholecystokinin, such as suppression of food intake.
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Cites
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Self-citationOn the specificity of naloxone as an opiate antagonist
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Cited by
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Metadata
- Authors
- Faris, P. L., Komisaruk, B. R., Watkins, L. R., & Mayer, D. J.
- Venue
- Science
- Published
- 1983-01-21
- Volume
- 219
- Issue
- 4582
- Pages
- 310-312
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070370133
- Cited by
- 578
- References
- 16
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Faris, P. L., Komisaruk, B. R., Watkins, L. R., & Mayer, D. J. (1983). Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia. Science. https://doi.org/10.1126/science.6294831
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
