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The ornithine decarboxylase gene is a transcriptional target of c-Myc.
Open accessAbstract
Constitutive c-myc expression suppresses cell cycle arrest, promotes entry into S phase, and results in the growth factor-independent expression of ornithine decarboxylase (ODC; EC 4.1.1.17). The ODC gene contains a conserved repeat of the Myc binding site, CACGTG, in intron 1. In this report, we demonstrate that c-Myc is a potent transactivator of ODC promoter-reporter gene constructs in fibroblasts that requires the CACGTG repeat. These sites conferred Myc responsiveness on heterologous promoter constructs, suggesting that ODC is regulated by Myc at the level of transcription initiation. Analysis of deletion and point mutants of c-myc revealed that domains required for transactivation of the ODC promoter did not include the leucine zipper of the Myc protein. This suggests that Myc may interact with transcription factors other than Max to transactivate the ODC gene.
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Citations
Cited by
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Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140
Reflecting on 25 years with MYC
Meyer, N., & Penn, L. Z. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2231 · Cited by 1,575
The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior
Grandori, C., Cowley, S. M., James, L. P., & Eisenman, R. N. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.653 · Cited by 1,333
Dang, C. V., O’Donnell, K. A., Zeller, K. I., Nguyen, T., Osthus, R. C., & Li, F. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.014 · Cited by 1,188
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Metadata
- Authors
- Bello-Fernandez, C., Packham, G., & Cleveland, J. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-08-15
- Volume
- 90
- Issue
- 16
- Pages
- 7804-7808
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1982172428
- Cited by
- 777
- References
- 0
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The ornithine decarboxylase gene is a transcriptional target of c-Myc. https://app.cochat.ai/papers/10.1073/pnas.90.16.7804
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- Bello-Fernandez, C., Packham, G., & Cleveland, J. L. (1993). The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.16.7804
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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