The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.
Open accessAbstract
The Ah receptor (AHR) is a basic helix-loop-helix protein that mediates the effects of 2,3,7,8-tetrachloro-dibenzo-p-dioxin. In this report, we describe a rabbit reticulocyte system that allows functional expression of both the AHR and its dimeric partner, the AHR nuclear translocator protein (ARNT). By using this in vitro system, we were able to reconstitute agonist binding to the AHR and agonist-induced AHR-ARNT recognition of a cognate DNA enhancer sequence. Expression of AHR deletion mutants revealed the location of N-terminal domains responsible for ligand and DNA recognition and C-terminal domains that play roles in agonist-induced DNA recognition.
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“Based on previous domain mapping studies, this mutation occurs in the PAS B domain, near a region predicted to encode the ligand and chaperone binding domains (Figure 2, Figure 4) (Dolwick, Swanson, et al., 1993; Fukunaga & Hankinson, 1996).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Dolwick, Swanson, et al., 1993
In the citing paper
“Interestingly, this C-ter loop also locates within a previously identified “repressor” region of ~ 200 residues that could be “depressed” by the agonist-induced receptor transformation16.”
From Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex (2025) · cites this paper as [16]
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Metadata
- Authors
- Dolwick, K. M., Swanson, H. I., & Bradfield, C. A.
- Affiliations
- Northwestern University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1993-09-15
- Volume
- 90
- Issue
- 18
- Pages
- 8566-8570
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC47398
- OpenAlex
- W1979697640
- Cited by
- 239
- References
- 37
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 7 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 3
- FWCI
- 17.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (T32 CA09560, T32CA009560)
- National Institute of Environmental Health Sciences (ES-05703, F32ES005589, ES-05589)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- aryl hydrocarbon receptor, ligand binding, DNA recognition, enhancers, bHLH transcription factors, 2,3,7,8-tetrachlorodibenzo-p-dioxin
- MeSH terms
- Polychlorinated Dibenzodioxins, Animals, Base Sequence, Binding Sites, Codon, DNA, Ligands, Molecular Sequence Data, Oligodeoxyribonucleotides, Rabbits, Receptors, Drug, Reticulocytes, Transcription, Genetic, Protein Biosynthesis, Blotting, Western, Polymerase Chain Reaction, Mutagenesis, Site-Directed, Sequence Deletion, Receptors, Aryl Hydrocarbon, Mice
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