Cited by 239Toxic Organic Pollutants ImpactPharmacogenetics and Drug MetabolismNuclear Receptors and Signaling

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In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.

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Dolwick, K M, Swanson, H I, Bradfield, C A·1993·Proceedings of the National Academy of Sciences

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Abstract

The Ah receptor (AHR) is a basic helix-loop-helix protein that mediates the effects of 2,3,7,8-tetrachloro-dibenzo-p-dioxin. In this report, we describe a rabbit reticulocyte system that allows functional expression of both the AHR and its dimeric partner, the AHR nuclear translocator protein (ARNT). By using this in vitro system, we were able to reconstitute agonist binding to the AHR and agonist-induced AHR-ARNT recognition of a cognate DNA enhancer sequence. Expression of AHR deletion mutants revealed the location of N-terminal domains responsible for ligand and DNA recognition and C-terminal domains that play roles in agonist-induced DNA recognition.

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Authors: Dolwick, K. M., Swanson, H. I., & Bradfield, C. A.
Affiliations: Northwestern University (US)
ORCID: Swanson, H I
Bradfield, C A
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1993-09-15
Volume: 90
Issue: 18
Pages: 8566-8570
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.90.18.8566
PMC: PMC47398
OpenAlex: W1979697640
Cited by: 239
References: 37
Citations by year: 2026: 2 · 2025: 1 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 7 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 3
FWCI: 17.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (T32 CA09560, T32CA009560)
National Institute of Environmental Health Sciences (ES-05703, F32ES005589, ES-05589)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: aryl hydrocarbon receptor, ligand binding, DNA recognition, enhancers, bHLH transcription factors, 2,3,7,8-tetrachlorodibenzo-p-dioxin
MeSH terms: Polychlorinated Dibenzodioxins, Animals, Base Sequence, Binding Sites, Codon, DNA, Ligands, Molecular Sequence Data, Oligodeoxyribonucleotides, Rabbits, Receptors, Drug, Reticulocytes, Transcription, Genetic, Protein Biosynthesis, Blotting, Western, Polymerase Chain Reaction, Mutagenesis, Site-Directed, Sequence Deletion, Receptors, Aryl Hydrocarbon, Mice

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In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.

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