The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain.
Open accessAbstract
Glutathione-independent prostaglandin D synthase [prostaglandin-H2 D-isomerase; (5Z,13E)-(15S)-9 alpha,11 alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase, EC 5.3.99.2] is an enzyme responsible for biosynthesis of prostaglandin D2 in the central nervous system. In situ hybridization with antisense RNA for the enzyme indicated that mRNA for the enzyme was predominantly expressed in the leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain. The findings agree with those obtained by immunohistochemical staining with antibodies against the enzyme. It was further revealed that prostaglandin D synthase activity was considerably greater in the isolated leptomeninges (14.2 nmol per min per mg of protein) and choroid plexus (7.0 nmol per min per mg of protein) than the activity in the whole brain (2.0 nmol per min per mg of protein). These results, taken together, indicate that the enzyme is mainly synthesized and located in the leptomeninges, choroid plexus, and oligodendrocytes in the brain.
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Citations
Cites
Molecular mechanisms of sleep‐wake regulation: roles of prostaglandins D 2 and E 2
Hayaishi, O. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.11.1907936 · Cited by 235
Self-citation
Cited by
Vane, J. R., Bakhle, Y. S., & Botting, R. M. (1998) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.97 · Cited by 2,734
Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis
Smith, W. L., Urade, Y., & Jakobsson, P.-J. (2011) · Chemical Reviews · doi:10.1021/cr2002992 · Cited by 503
Self-citationUrade, Y., & Hayaishi, O. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00161-8 · Cited by 332
Self-citationBiochemical regulation of non-rapid-eye-movement sleep
Krueger, J. M. (2003) · Frontiers in Bioscience · doi:10.2741/1033 · Cited by 329
Neural circuitry engaged by prostaglandins during the sickness syndrome
Saper, C. B., Romanovsky, A. A., & Scammell, T. E. (2012) · Nature Neuroscience · doi:10.1038/nn.3159 · Cited by 285
Metadata
- Authors
- Urade, Y., Kitahama, K., Ohishi, H., Kaneko, T., Mizuno, N., & Hayaishi, O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-10
- Volume
- 90
- Issue
- 19
- Pages
- 9070-9074
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2082635345
- Cited by
- 238
- References
- 1
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Urade, Y., Kitahama, K., Ohishi, H., Kaneko, T., Mizuno, N., & Hayaishi, O. (1993). Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.19.9070
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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