Biochemical regulation of non-rapid-eye-movement sleep
Open accessAbstract
The concept, that sleep regulatory substances (sleep factors) exist, stems from classical endocrinology and is supported by positive transfer experiments in which tissue fluids obtained from sleepy or sleeping animals elicited sleep when injected into recipient animals. The transfer experiments concluded with the identification of four sleep factors: delta sleep-inducing peptide (DSIP), uridine, oxidized glutathione, and a muramyl peptide. A physiological sleep regulatory role, however, has not been determined for these substances. In contrast, transfer experiments did not play a part in the development of the strong experimental evidence that implicated the currently known sleep factors in sleep regulation. These substances include adenosine, prostaglandin D2 (PGD2), growth hormone-releasing hormone (GHRH), interleukin-1 (IL1) and tumor necrosis factor (TNF). They promote non-REMS in various species, inhibition of their action or endogenous production results in loss of spontaneous sleep, and their synthesis and/or release display variations correlating with sleep-wake activity. Although the source of these substances vary they all enhance sleep by acting in the basal forebrain/anterior hypothalamus--preoptic region. It is also characteristic of these substances that they interact in multiple ways often resulting in mutual stimulation or potentiation of each other. Finally, there is a third group of substances whose significance in sleep regulation is less clear but for which there are two or more lines of evidence suggesting that they may have a role in modulating non-REM sleep (NREMS). This group includes oleamide, cortistatin, cholecystokinin (CCK), insulin, and nitric oxide (NO). More sleep regulatory substances are likely to be discovered in the future although it is a long and difficult process requiring multiple laboratories to generate sufficient convincing data to implicate any one of them in sleep regulation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Administration of either IL-1 or TNF promotes NREM sleep.
“Administration of either IL-1 or TNF promotes NREM sleep (Obal and Krueger, 2003;Opp, 2005;Krueger, 2008).”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Obal and Krueger, 2003
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479 · see citing works
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
Cravatt, B. F., Giang, D. K., Mayfield, S. P., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1996) · Nature · doi:10.1038/384083a0 · Cited by 2,125 · see citing works
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
Wallach, D., Varfolomeev, E. E., Malinin, N. L., Goltsev, Y. V., Kovalenko, A. V., & Boldin, M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.331 · Cited by 1,299 · see citing works
Adenosine: A Mediator of the Sleep-Inducing Effects of Prolonged Wakefulness
Porkka-Heiskanen, T., Strecker, R. E., Thakkar, M., Bjørkum, A. A., Greene, R. W., & McCarley, R. W. (1997) · Science · doi:10.1126/science.276.5316.1265 · Cited by 1,252 · see citing works
Kriegler, M., Perez, C. F., DeFay, K., Albert, I., & Lu, S.-D. (1988) · Cell · doi:10.1016/0092-8674(88)90486-2 · Cited by 1,090 · see citing works
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3950 · Cited by 974 · see citing works
Restoration of brain energy metabolism as the function of sleep
Benington, J. H., & Heller, H. C. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)00057-o · Cited by 828 · see citing works
Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus
Breder, C. D., Dinarello, C. A., & Saper, C. B. (1988) · Science · doi:10.1126/science.3258444 · Cited by 759 · see citing works
Evidence for an Endogenous Ultradian Rhythm Governing Growth Hormone Secretion in the Rat
Tannenbaum, G. S., & Martin, J. B. (1976) · Endocrinology · doi:10.1210/endo-98-3-562 · Cited by 749 · see citing works
Biological actions of cholecystokinin
Crawley, J. N., & Corwin, R. L. (1994) · Peptides · doi:10.1016/0196-9781(94)90104-x · Cited by 713 · see citing works
Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex
Greenfeder, S. A., Nunes, P., Kwee, L., Labow, M., Chizzonite, R., & Ju, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.23.13757 · Cited by 639 · see citing works
Chemical characterization of a family of brain lipids that induce sleep
Cravatt, B. F., Prospero-Garcia, O., Siuzdak, G., Gilula, N. B., Henriksen, S. J., Boger, D. L., & Lerner, R. A. (1995) · Science · doi:10.1126/science.7770779 · Cited by 620 · see citing works
Cholecystokinin elicits the complete behavioral sequence of satiety in rats.
Antin, J. H., Gibbs, J., Holt, J., Young, R. C., & Smith, G. P. (1975) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077040 · Cited by 613 · see citing works
Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease
Boka, G., Anglade, P., Wallach, D., Javoy-Agid, F., Agid, Y., & Hirsch, É. C. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90684-x · Cited by 591 · see citing works
Fontaine, V. K., Mohand‐Saïd, S., Hanoteau, N., Fuchs, C., Pfizenmaier, K., & Eisel, U. L. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-j0001.2002 · Cited by 587 · see citing works
Toll-like receptors; their physiological role and signal transduction system.
Takeuchi, O., & Akira, S. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00010-8 · Cited by 506 · see citing works
Porkka‐Heiskanen, T., Strecker, R. E., & McCarley, R. W. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00220-7 · Cited by 463 · see citing works
Sleep-promoting effects of endogenous pyrogen (interleukin-1)
Krueger, J. M., Walter, J., Dinarello, C. A., Wolff, S. M., & CHEDID, L. A. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.6.r994 · Cited by 456 · see citing works
Self-citationRegulatory Function of Adenosine
(1983) · Springer eBooks · doi:10.1007/978-1-4613-3909-0 · Cited by 454 · see citing works
The Role of Cytokines in Physiological Sleep Regulation
Krueger, J. M., Obál, F., Fang, J., Kubota, T., & Taishi, P. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05826.x · Cited by 423 · see citing works
Self-citationA cortical neuropeptide with neuronal depressant and sleep-modulating properties
de Lecea, L., Criado, J. R., Prospero-Garcia, O. E., Gautvik, K. M., Schweitzer, P., Danielson, P. E., Dunlop, C. L. M., Siggins, G. R., Henriksen, S. J., & Sutcliffe, J. G. (1996) · Nature · doi:10.1038/381242a0 · Cited by 414 · see citing works
The type II ‘decoy’ receptor: A novel regulatory pathway for interleukin 1
Colotta, F., Dower, S., Sims, J. E., & Mantovani, A. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90217-8 · Cited by 378 · see citing works
Späth‐Schwalbe, E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.5.1573 · Cited by 377 · see citing works
Cirelli, C., & Tononi, G. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09187.2000 · Cited by 369 · see citing works
Strecker, R. E., Morairty, S. R., Thakkar, M. M., Porkka‐Heiskanen, T., Basheer, R., Dauphin, L., Rainnie, D. G., Portas, C. M., Greene, R. W., & McCarley, R. W. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00258-8 · Cited by 356 · see citing works
Vgontzas, A. N., Zoumakis, M., Papanicolaou, D. A., Bixler, E. O., Prolo, P., Lin, H.-M., Vela-Bueno, A., Kales, A., & Chrousos, G. P. (2002) · Metabolism · doi:10.1053/meta.2002.33357 · Cited by 329 · see citing works
Merrill, J. E. (1992) · Developmental Neuroscience · doi:10.1159/000111642 · Cited by 317 · see citing works
Ehlers, C. L., Reed, T. K., & Henriksen, S. J. (2008) · Neuroendocrinology · doi:10.1159/000124489 · Cited by 310 · see citing works
Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep
Shoham, S., Davenne, D., Cady, A. B., Dinarello, C. A., & Krueger, J. M. (1987) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1987.253.1.r142 · Cited by 290 · see citing works
Self-citationKong, J., Shepel, P. N., Holden, C. P., Mackiewicz, M., Pack, A. I., & Geiger, J. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05581.2002 · Cited by 281 · see citing works
Pappenheimer, J. R., Koski, G., Fencl, V., Karnovsky, M. L., & Krueger, J. M. (1975) · Journal of Neurophysiology · doi:10.1152/jn.1975.38.6.1299 · Cited by 270 · see citing works
Self-citationAn adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons
Scammell, T. E., Gerashchenko, D., Mochizuki, T., McCarthy, M. T., Estabrooke, I. V., Sears, C., Saper, C. B., Urade, Y., & Hayaishi, O. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00383-9 · Cited by 269 · see citing works
Expression of TNF and TNF Receptors (p55 and p75) in the Rat Brain after Focal Cerebral Ischemia
Botchkina, G. I., Meistrell, M. E., Botchkina, I. L., & Tracey, K. J. (1997) · Molecular Medicine · doi:10.1007/bf03401714 · Cited by 266 · see citing works
Endogenous sleep-promoting substances and sleep regulation
Borbely, A. A., & Tobler, I. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.2.605 · Cited by 259 · see citing works
Yang, L., Lindholm, K., Konishi, Y., Li, R., & Shen, Y. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03025.2002 · Cited by 255 · see citing works
Obstructive Sleep Apnea Syndrome and Circadian Rhythms of Hormones and Cytokines
Entzian, P., Linnemann, K., Schlaak, M. S., & Zabel, P. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.3.8630548 · Cited by 248 · see citing works
Guan, X., Cravatt, B. F., Ehring, G. R., Hall, J. E., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.7.1785 · Cited by 242 · see citing works
Urade, Y., Kitahama, K., Ohishi, H., Kaneko, T., Mizuno, N., & Hayaishi, O. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9070 · Cited by 238 · see citing works
Sawchenko, P. E., Swanson, L. W., Rivier, J., & Vale, W. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902370108 · Cited by 236 · see citing works
Interleukin 1 alters rat sleep: temporal and dose-related effects
Opp, M. R., Obal, F., & Krueger, J. M. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.1.r52 · Cited by 232 · see citing works
Self-citationBenington, J. H., Kodali, S., & Heller, H. C. (1995) · Brain Research · doi:10.1016/0006-8993(95)00590-m · Cited by 228 · see citing works
Prostaglandin D2, a cerebral sleep-inducing substance in monkeys.
Onoe, H., Ueno, R., Fujita, I., Nishino, H., Oomura, Y., & Hayaishi, O. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.4082 · Cited by 225 · see citing works
Lichtman, A. H., Hawkins, E. G., Griffin, G., & Cravatt, B. F. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.302.1.73 · Cited by 224 · see citing works
IL-1 and IL-18 receptors, and their extended family
Sims, J. E. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00306-5 · Cited by 211 · see citing works
Steiger, A., Guldner, J., Hemmeter, U., Rothe, B., Wiedemann, K., & Holsboer, F. (2008) · Neuroendocrinology · doi:10.1159/000126275 · Cited by 209 · see citing works
Role of Adenosine as a Modulator of Synaptic Activity in the Central Nervous System
Brundege, J. M., & Dunwiddie, T. V. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60076-9 · Cited by 208 · see citing works
Role of adenosine in behavioral state modulation: a microdialysis study in the freely moving cat
Portas, C. M., Thakkar, M. M., Rainnie, D. G., Greene, R. W., & McCarley, R. W. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00640-9 · Cited by 208 · see citing works
Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions
Spier, A. D., & de Lecea, L. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00031-x · Cited by 196 · see citing works
The composition of sleep-promoting factor isolated from human urine.
Krueger, J. M., Pappenheimer, J. R., & Karnovsky, M. L. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68088-9 · Cited by 192 · see citing works
Self-citationNeuroendocrine regulation of growth hormone
Bertherat, J. Y., Bluet‐Pajot, M., & Epelbaum, J. (1995) · European Journal of Endocrinology · doi:10.1530/eje.0.1320012 · Cited by 186 · see citing works
Mizoguchi, A., Eguchi, N., Kimura, K., Kiyohara, Y., Qu, W., Huang, Z., Mochizuki, T., Lazarus, M., Kobayashi, T., Kaneko, T., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201398898 · Cited by 185 · see citing works
Adaptation of the 24-h growth hormone profile to a state of sleep debt
Spiegel, K., Leproult, R., Colecchia, E. F., L'Hermite-Balériaux, M., Nie, Z., Copinschi, G., & Van Cauter, E. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.3.r874 · Cited by 183 · see citing works
Sleep-promoting effects of cerebrospinal fluid from sleep-deprived goats.
Pappenheimer, J. R., Miller, T. B., & Goodrich, C. A. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.2.513 · Cited by 177 · see citing works
Anandamide may mediate sleep induction
Mechoulam, R., Fride, E., Hanu, L., Sheskin, T., Bisogno, T., Marzo, V. D., Bayewitch, M. L., & Vogel, Z. (1997) · Nature · doi:10.1038/37891 · Cited by 175 · see citing works
Growth Hormone-Releasing Hormone: Synthesis and Signaling
Mayo, K. E., Godfrey, P. A., Suhr, S. T., Kulik, D. J., & Rahal, J. O. (1995) · Elsevier eBooks · doi:10.1016/b978-0-12-571150-0.50007-x · Cited by 174 · see citing works
Prostaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats
Ueno, R., Ishikawa, Y., Nakayama, T., & Hayaishi, O. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(82)91760-0 · Cited by 172 · see citing works
Alam, M. N., Szymusiak, R. S., Gong, H., King, J., & McGinty, D. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00679.x · Cited by 169 · see citing works
Leonard, T. O., & Lydic, R. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00774.1997 · Cited by 165 · see citing works
Dependence of sleep on nutrients' availability
Danguir, J., & Nicolaidis, S. (1979) · Physiology & Behavior · doi:10.1016/0031-9384(79)90240-3 · Cited by 164 · see citing works
Capsaicin application to central or peripheral vagal fibers attenuates CCK satiety
South, E. H., & Ritter, R. C. (1988) · Peptides · doi:10.1016/0196-9781(88)90171-4 · Cited by 163 · see citing works
Interleukin-1 derived from astrocytes enhances slow wave activity in sleep EEG of the rat
Tobler, I., Borbély, A. A., Schwyzer, M., & Fontana, A. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90391-1 · Cited by 161 · see citing works
Somatostatin receptors in the central nervous system
Schindler, M., Humphrey, P. P. A., & Emson, P. C. (1996) · Progress in Neurobiology · doi:10.1016/0301-0082(96)00030-5 · Cited by 156 · see citing works
Growth hormone-releasing factor enhances sleep in rats and rabbits
Obál, F., Alföldi, P., Cady, A. B., Johannsen, L., Sáry, G., & Krueger, J. M. (1988) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1988.255.2.r310 · Cited by 153 · see citing works
Self-citationSleep as neuronal detoxification and restitution
Inoué, S., Honda, K., & Komoda, Y. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00014-k · Cited by 151 · see citing works
Sleep deprivation induces brain region-specific decreases in glutathione levels
D’Almeida, V., Lobo, L. L., Hipólide, D. C., de Oliveira, A. C., Nóbrega, J. N., & Tufilk, S. (1998) · Neuroreport · doi:10.1097/00001756-199808240-00031 · Cited by 150 · see citing works
Opp, M. R., Smith, E. M., & Hughes, T. K. (1995) · Journal of Neuroimmunology · doi:10.1016/0165-5728(95)00066-b · Cited by 145 · see citing works
Cortistatin Is Expressed in a Distinct Subset of Cortical Interneurons
de Lecea, L., del Rı́o, J. A., Criado, J. R., Alcántara, S., Morales, M., Danielson, P. E., Henriksen, S. J., Soriano, E., & Sutcliffe, J. G. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05868.1997 · Cited by 144 · see citing works
Anandamide modulates sleep and memory in rats
Murillo‐Rodríguez, E., Sánchez-Alavez, M., Navarro, L., Martı́nez-González, D., Drucker-Colı́n, R., & Prospero-Garcia, O. E. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00969-x · Cited by 143 · see citing works
Riou, F., Cespuglio, R., & Jouvet, M. (1982) · Neuropeptides · doi:10.1016/0143-4179(82)90016-6 · Cited by 140 · see citing works
Influences of Fat and Carbohydrate on Postprandial Sleepiness, Mood, and Hormones
Wells, A. S., Read, N. W., Uvnäs‐Moberg, K., & Alster, P. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00519-7 · Cited by 137 · see citing works
Inhibition of nitric oxide synthesis inhibits rat sleep
Kapás, L., Fang, J., & Krueger, J. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91969-0 · Cited by 133 · see citing works
Self-citationDeghenghi, R., Papotti, M. G., Ghigo, E., & Muccioli, G. (2001) · Journal of Endocrinological Investigation · doi:10.1007/bf03343800 · Cited by 133 · see citing works
Factors in cerebrospinal fluid from goats that affect sleep and activity in rats*
Fencl, V., Koski, G., & Pappenheimer, J. R. (1971) · The Journal of Physiology · doi:10.1113/jphysiol.1971.sp009541 · Cited by 128 · see citing works
Inhibition of nitric oxide synthesis suppresses sleep in rabbits
Kapás, L., Shibata, M., Kimura, M., & Krueger, J. M. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.1.r151 · Cited by 128 · see citing works
Self-citationZängerle, L., Cuénod, M., Winterhalter, K. H., & Kim, Q. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08889.x · Cited by 122 · see citing works
Darko, D. F., Miller, J. C., Gallen, C., White, J., Koziol, J., Brown, S. J., Hayduk, R., Atkinson, J. H., Assmus, J., & Munnell, D. T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12080 · Cited by 121 · see citing works
Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep
Pinzar, E., Kanaoka, Y., Inui, T., Eguchi, N., Urade, Y., & Hayaishi, O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090093997 · Cited by 117 · see citing works
Sleep and Cerebrospinal Fluid Interleukin-1-Like Activity in the Cat
Lue, F. A., Bail, M., Jephthah-Ochola, J., Carayanniotis, K., Gorczynski, R. M., & Moldofsky, H. (1988) · International Journal of Neuroscience · doi:10.3109/00207458808991595 · Cited by 116 · see citing works
Is vasoactive intestinal polypeptide (VIP) a sleep factor?
Drucker-Colı́n, R., Bernal-Pedraza, J., Fernández-Cancino, F., & Oksenberg, A. (1984) · Peptides · doi:10.1016/0196-9781(84)90032-9 · Cited by 116 · see citing works
Dourish, C. T., RUCKERT, A. C. F., Tattersall, F. D., & Iversen, S. D. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90528-1 · Cited by 116 · see citing works
Conditions that affect sleep alter the expression of molecules associated with synaptic plasticity
Taishi, P., Sanchez, C., Wang, Y., Fang, J., Harding, J. W., & Krueger, J. M. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.3.r839 · Cited by 116 · see citing works
Self-citationInterleukin-6 is pyrogenic but not somnogenic
Opp, M. R., Obál, F., Cady, A. B., Johannsen, L., & Krueger, J. M. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90239-4 · Cited by 112 · see citing works
Self-citationRam, A., Pandey, H. P., Matsumura, H., Kasahara-Orita, K., Nakajima, T., Takahata, R., Satoh, S., Terao, A., & Hayaishi, O. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01401-1 · Cited by 112 · see citing works
Effects of Sleep on the Production of Cytokines in Humans
Uthgenannt, D., Schoolmann, D., Pietrowsky, R., Fehm, H.-L., & Born, J. (1995) · Psychosomatic Medicine · doi:10.1097/00006842-199503000-00001 · Cited by 112 · see citing works
The effect of growth hormone administration on human sleep: a dose-response study.
Mendelson, W. B., Slater, S., Gold, P., & Gillin, J. C. (1980) · PubMed · Cited by 111 · see citing works
Krueger, J. M., Karnovsky, M. L., Martin, S. A., Pappenheimer, J. R., Walter, J., & Biemann, K. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)90796-9 · Cited by 111 · see citing works
Self-citationDiurnal Variations of Tumor Necrosis Factor Alpha mRNA and Alpha-Tubulin mRNA in Rat Brain
Bredow, S., Guha‐Thakurta, N., Taishi, P., Obál, F., & Krueger, J. M. (1997) · NeuroImmunoModulation · doi:10.1159/000097325 · Cited by 111 · see citing works
Self-citationObál, F., Payne, L., Kapás, L., Opp, M. R., & Krueger, J. M. (1991) · Brain Research · doi:10.1016/0006-8993(91)90128-i · Cited by 111 · see citing works
Self-citationCerebrodiene: a brain lipid isolated from sleep-deprived cats.
Lerner, R. A., Siuzdak, G. E., Prospero-Garcia, O. E., Henriksen, S. J., Boger, D. L., & Cravatt, B. F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9505 · Cited by 110 · see citing works
Growth Hormone Effects on Sleep and Wakefulness in the Rat
Drucker-Colín, R., Spanis, C. W., Hunyadi, J., Sassin, J. F., & McGaugh, J. L. (2008) · Neuroendocrinology · doi:10.1159/000122377 · Cited by 108 · see citing works
Genomic structure, induction, and production of TNF-alpha.
Spriggs, D. R., Deutsch, S., & Kufe, D. W. (1992) · PubMed · Cited by 107 · see citing works
The effects of immunolesions of nerve growth factor-receptive neurons by 192 IgG-saporin on sleep
Kapás, L., Obál, F., Book, A. A., Schweitzer, J. B., Wiley, R. G., & Krueger, J. M. (1996) · Brain Research · doi:10.1016/0006-8993(95)01431-4 · Cited by 107 · see citing works
Self-citationAnti-interleukin-1 beta reduces sleep and sleep rebound after sleep deprivation in rats
Opp, M. R., & Krueger, J. M. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.3.r688 · Cited by 107 · see citing works
Self-citationBasheer, R., Porkka‐Heiskanen, T., Stenberg, D., & McCarley, R. W. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00219-3 · Cited by 106 · see citing works
Intrapreoptic Microinjection of GHRH or Its Antagonist Alters Sleep in Rats
Zhang, J., Obál, F., Zheng, T., Fang, J., Taishi, P., & Krueger, J. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02187.1999 · Cited by 103 · see citing works
Self-citationLiposits, Z., Merchenthaler, I. J., Paull, W. K., & Flerk�, B. (1988) · Histochemistry and Cell Biology · doi:10.1007/bf00493148 · Cited by 102 · see citing works
Inoué, S., Honda, K., Komoda, Y., Uchizono, K., Ueno, R., & Hayaishi, O. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.6240 · Cited by 100 · see citing works
Bilezikjian, L. M., SEIFERT, H., & Vale, W. (1986) · Endocrinology · doi:10.1210/endo-118-5-2045 · Cited by 99 · see citing works
Krueger, J. M., Takahashi, S., Kapás, L., Bredow, S., Roky, R., Fang, J., Floyd, R. A., Renegar, K. B., Guha‐Thakurta, N., Novitsky, S. V., et al. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(95)00007-o · Cited by 98 · see citing works
Self-citationDelta-sleep-inducing peptide (DSIP): An update
Graf, M., & Kastin, A. J. (1986) · Peptides · doi:10.1016/0196-9781(86)90148-8 · Cited by 98 · see citing works
Brain-derived neurotrophic factor enhances spontaneous sleep in rats and rabbits
Kushikata, T., Fang, J., & Krueger, J. M. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.5.r1334 · Cited by 95 · see citing works
Self-citationEffects of systemic GHRH on sleep in intact and hypophysectomized rats
Obál, F., Floyd, R., Kapás, L., Bodosi, B., & Krueger, J. M. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.2.e230 · Cited by 94 · see citing works
Self-citationCharacterization of the hypnotic properties of oleamide
Basile, A. S., Hanuš, L., & Mendelson, W. B. (1999) · Neuroreport · doi:10.1097/00001756-199904060-00010 · Cited by 93 · see citing works
Basheer, R., Rainnie, D. G., Porkka‐Heiskanen, T., Ramesh, V., & McCarley, R. W. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00111-7 · Cited by 93 · see citing works
Interleukin-1 is involved in responses to sleep deprivation in the rabbit
Opp, M. R., & Krueger, J. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91764-7 · Cited by 93 · see citing works
Self-citationInterferon alpha-2 enhances slow-wave sleep in rabbits
Krueger, J. M., Dinarello, C. A., Shoham, S., Davenne, D., Walter, J., & Kubillus, S. L. (1987) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(87)90107-x · Cited by 93 · see citing works
Self-citationHuitrón‐Reséndiz, S., Gombart, L. M., Cravatt, B. F., & Henriksen, S. J. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7792 · Cited by 92 · see citing works
Cloning and Characterization of an Alternatively Processed Human Type II Interleukin-1 Receptor mRNA
Liu, C., Hart, R. P., Liu, X.-J., Clevenger, W., Maki, R. A., & Souza, E. B. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20965 · Cited by 87 · see citing works
Somnogenic relationships between tumor necrosis factor and interleukin-1
Takahashi, S., Kapás, L., Fang, J., & Krueger, J. M. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.4.r1132 · Cited by 87 · see citing works
Self-citationNitric Oxide Donors SIN-1 and SNAP Promote Nonrapid-Eye-Movement Sleep in Rats
Kapás, L., & Krueger, J. M. (1996) · Brain Research Bulletin · doi:10.1016/s0361-9230(96)00227-4 · Cited by 86 · see citing works
Self-citationDelta-sleep-inducing peptide (DSIP): A review
Graf, M., & Kastin, A. J. (1984) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(84)90022-8 · Cited by 86 · see citing works
Obál, F., Payne, L., Opp, M. R., Alföldi, P., Kapás, L., & Krueger, J. M. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.263.5.r1078 · Cited by 86 · see citing works
Self-citationAdenosine: a Mediator of Interleukin-1β-Induced Hippocampal Synaptic Inhibition
Luk, W. P., Zhang, Y., White, T. D., Lue, F. A., Wu, C., Jiang, C., Zhang, L., & Moldofsky, H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04238.1999 · Cited by 85 · see citing works
Inhibition of sleep in rats by inorganic selenium compounds, inhibitors of prostaglandin D synthase.
Matsumura, H., Takahata, R., & Hayaishi, O. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9046 · Cited by 82 · see citing works
The Hypnotic Actions of the Fatty Acid Amide, Oleamide
Mendelson, W. B. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00341-4 · Cited by 82 · see citing works
Toppila, J. P., Alanko, L., Asikainen, M., Tobler, I., Stenberg, D., & Porkka‐Heiskanen, T. (1997) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1997.00049.x · Cited by 81 · see citing works
Kurosawa, M., Uvnäs‐Moberg, K., Miyasaka, K., & Lundeberg, T. (1997) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(96)00111-7 · Cited by 81 · see citing works
Perras, B., Marshall, L., Köhler, G., Jan Born, A., & Fehm, H. L. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00027-x · Cited by 80 · see citing works
Kapás, L., Obál, F., Alföldi, P., Rubicsek, G., Penke, B., & Obál, F. (1988) · Brain Research · doi:10.1016/0006-8993(88)91334-0 · Cited by 80 · see citing works
Cortical administration of somatostatin (SRIF): Effect on sleep and motor behavior
Rezek, M., Havlicek, V., Hughes, K. R., & Friesen, H. G. (1976) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(76)90290-2 · Cited by 78 · see citing works
Changes in Brain Glycogen During Slow‐Wave Sleep in the Rat
Karnovsky, M. L., Reich, P., Anchors, J. M., & Burrows, B. L. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb00853.x · Cited by 78 · see citing works
Huiguo, L., Jin, L., Shengdao, X., Guan-xin, S., Zhang, Z., & Xu, Y. (2000) · Current Medical Science · doi:10.1007/bf02886988 · Cited by 77 · see citing works
An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits
Takahashi, S., ́s, L. K., Fang, J., & Krueger, J. M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00609-t · Cited by 77 · see citing works
Self-citationFunction of microglia in organotypic slice cultures
Czapiga, M., & Colton, C. A. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990615)56:6 · Cited by 77 · see citing works
Somnogenic cytokines and models concerning their effects on sleep.
Jm, K., Obál, F., Opp, M., Toth, L. A., Johannsen, L., & Cady, A. B. (1990) · PubMed Central · Cited by 76 · see citing works
Nitric oxide and sleep in the rat: a puzzling relationship
Burlet, S., Léger, L., & Cespuglio, R. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00031-7 · Cited by 75 · see citing works
Rosenberg, P. A., Li, Y., Le, M., & Zhang, Y. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06294.2000 · Cited by 73 · see citing works
Zhang, J., Obál, F., Fang, J., Collins, B., & Krueger, J. M. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13232-8 · Cited by 72 · see citing works
Self-citationCircadian variation of nitric oxide synthase activity and cytosolic protein levels in rat brain
Ayers, N. A., Kapás, L., & Krueger, J. M. (1996) · Brain Research · doi:10.1016/0006-8993(95)01362-8 · Cited by 72 · see citing works
Self-citationInhibition of tumor necrosis factor attenuates physiological sleep in rabbits
Takahashi, S., Kapás, L., Seyer, J. M., Wang, Y., & Krueger, J. M. (1996) · Neuroreport · doi:10.1097/00001756-199601310-00063 · Cited by 71 · see citing works
Self-citationSomatostatin Impairs Sleep in Elderly Human Subjects
Frieboes, R.-M. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00244-8 · Cited by 70 · see citing works
Intrahypothalamic connections: An electron microscopic study in the rat
Z�borszky, L., & Makara, G. B. (1979) · Experimental Brain Research · doi:10.1007/bf00235668 · Cited by 70 · see citing works
Tumor necrosis factor-beta induces sleep, fever, and anorexia
Kapás, L., & Krueger, J. M. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.263.3.r703 · Cited by 70 · see citing works
Self-citationKruisbrink, J., Mirmiran, M., van der Woude, T. P., & Boer, G. J. (1987) · Brain Research · doi:10.1016/0006-8993(87)90570-1 · Cited by 69 · see citing works
Oxidized glutathione regulates physiological sleep in unrestrained rats
Honda, K., Komoda, Y., & Inoué, S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91024-3 · Cited by 69 · see citing works
Terao, A., Matsumura, H., & Saito, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06599.1998 · Cited by 69 · see citing works
Interleukin-18 promotes sleep in rabbits and rats
Kubota, T., Fang, J., Brown, R. A., & Krueger, J. M. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.3.r828 · Cited by 69 · see citing works
Self-citationInterleukin-10 Inhibits Spontaneous Sleep in Rabbits
Kushikata, T., Fang, J., & Krueger, J. M. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313244 · Cited by 69 · see citing works
Self-citationCholecystokinin (CCK-8) elicits prandial sleep in rats
Mansbach, R. S., & LORENZ, D. (1983) · Physiology & Behavior · doi:10.1016/0031-9384(83)90002-1 · Cited by 68 · see citing works
Brain energy metabolism : an integrated cellular perspective
Magistretti, P. J., Pellerin, L., & Martin, J. (1995) · Infoscience (Ecole Polytechnique Fédérale de Lausanne) · Cited by 65 · see citing works
Cytokine Production during Sleep and Wakef ulness and Its Relationship to Cortisol in Healthy Humans
Hohagen, F., Timmer, J., Weyerbrock, A., Rosemarie Fritsch, M., Ganter, U., Krieger, S., Berger, T., & Bauer, J. (2008) · Neuropsychobiology · doi:10.1159/000118993 · Cited by 65 · see citing works
Pre-eclampsia is Associated with Marked Alterations in Sleep Architecture
Edwards, N., Blyton, D. M., Kesby, G., Wilcox, I., & Sullivan, C. (2000) · SLEEP · doi:10.1093/sleep/23.5.1d · Cited by 64 · see citing works
Hypothalamic growth hormone-releasing hormone mRNA varies across the day in rats
Bredow, S., Taishi, P., Obél, F., Guha‐Thakurta, N., & Krueger, J. M. (1996) · Neuroreport · doi:10.1097/00001756-199611040-00020 · Cited by 64 · see citing works
Self-citationObál, F., Fang, J., Taishi, P., Kacsoh, B. Z., Gardi, J., & Krueger, J. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02912.2001 · Cited by 64 · see citing works
Self-citationGardi, J., Obál, F., Fang, J., Zhang, J., & Krueger, J. M. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.5.r1339 · Cited by 64 · see citing works
Self-citationGRF Neurons in the rat hypothalamus
Daikoku, S., Kawano, H., Noguchi, M., Nakanishi, J., Tokuzen, M., Chihara, K., & Nagatsu, I. (1986) · Brain Research · doi:10.1016/0006-8993(86)91515-5 · Cited by 63 · see citing works
Ultradian rhythm of growth hormone secretion and sleep in the adult male rat.
Kimura, F., & Tsai, C. W. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015337 · Cited by 63 · see citing works
Growth-Hormone-Releasing Hormone Mediates the Sleep-Promoting Activity of Interleukin-1 in Rats
Obál, F., Fang, J., Payne, L. C., & Krueger, J. M. (2008) · Neuroendocrinology · doi:10.1159/000126880 · Cited by 62 · see citing works
Self-citationInhibition of tumor necrosis factor in the brain suppresses rabbit sleep
Takahashi, S., Tooley, D. D., Kap�s, L., Fang, J., Seyer, J. M., & Krueger, J. M. (1995) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00410186 · Cited by 62 · see citing works
Self-citationTakahashi, S., Kapás, L., Fang, J., Seyer, J. M., Wang, Y., & Krueger, J. M. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.1.r101 · Cited by 60 · see citing works
Self-citation井上, 昌. (1989) · CRC Press eBooks · Cited by 59 · see citing works
Imeri, L., Opp, M. R., & Krueger, J. M. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.265.4.r907 · Cited by 59 · see citing works
Self-citationSleep and nitric: oxide: effects of 7-nitro indazole, inhibitor of brain nitric oxide synthase
Dzoljic, M., de Vries, R., & van Leeuwen, R. (1996) · Brain Research · doi:10.1016/0006-8993(96)00102-3 · Cited by 59 · see citing works
Activation of the systemic production of tumor necrosis factor after exposure to acute stress.
Yamasu, K., Shimada, Y., Sakaizumi, M., Soma, G., & Mizuno, D. (1992) · PubMed · Cited by 57 · see citing works
Epidermal growth factor enhances spontaneous sleep in rabbits
Kushikata, T., Fang, J., Chen, Z., Wang, Y., & Krueger, J. M. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.2.r509 · Cited by 56 · see citing works
Self-citationOpp, M. R., Postlethwaite, A. E., Seyer, J. M., & Krueger, J. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.3726 · Cited by 55 · see citing works
Self-citationRehman, A., Taishi, P., Fang, J., Majde, J. A., & Krueger, J. M. (2001) · Cytokine · doi:10.1006/cyto.2000.0800 · Cited by 55 · see citing works
Self-citationSleep deprivation decreases glycogen in the cerebellum but not in the cortex of young rats
Gip, P., Hagiwara, G., Ruby, N. F., & Heller, H. C. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00735.2001 · Cited by 55 · see citing works
Pandey, H. P., Ram, A., Matsumura, H., & Hayaishi, O. (1995) · PubMed · Cited by 55 · see citing works
Behavioural and electrocortical spectrum power effects of growth hormone releasing factor in rats
Nisticò, G., Sarro, G. D., Bagetta, G., & Müller, E. E. (1987) · Neuropharmacology · doi:10.1016/0028-3908(87)90047-5 · Cited by 53 · see citing works
Uridine as an active component of sleep-promoting substance: its effects on nocturnal sleep in rats
Honda, K., Komoda, Y., Nishida, S., Nagasaki, H., Higashi, A., Uchizono, K., & Inoué, S. (1984) · Neuroscience Research · doi:10.1016/s0168-0102(84)80003-6 · Cited by 53 · see citing works
Dobolyi, Á., Reichart, A., Szikra, T., Nyitrai, G., Kékesi, K. A., & Juhász, G. D. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(99)00162-x · Cited by 52 · see citing works
Brandt, J. A., Churchill, L., Guan, Z., Fang, J., Chen, L., & Krueger, J. M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02149-7 · Cited by 52 · see citing works
Self-citationBeranek, L., Hajdu, I., Gardi, J., Taishi, P., Obál, F., & Krueger, J. M. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.5.r1297 · Cited by 52 · see citing works
Self-citationLanneau, C., Peineau, S., Petit, F., Epelbaum, J., & Gardette, R. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.3.1464 · Cited by 52 · see citing works
Elevated levels of tumor necrosis factor alpha in postdialysis fatigue
DREISBACH, A., Hendrickson, T., Beezhold, D. H., Riesenberg, L. A., & Sklar, A. H. (1998) · The International Journal of Artificial Organs · doi:10.1177/039139889802100204 · Cited by 51 · see citing works
Oleamide modulates memory in rats
Murillo‐Rodríguez, E., Giòrdano, M., Cabeza, R. D. J., Henriksen, S. J., Méndez‐Díaz, M., Navarro, L., & Prospero-Garcia, O. E. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02256-x · Cited by 49 · see citing works
Yamuy, J., Morales, F. R., & Chase, M. H. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00052-k · Cited by 48 · see citing works
Imeri, L., Mancia, M., & Opp, M. R. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00006-8 · Cited by 47 · see citing works
The locus coeruleus and immediate-early genes in spontaneous and forced wakefulness
Tononi, G., Pompeiano, M., & Cirelli, C. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90173-2 · Cited by 46 · see citing works
Sleep of transgenic mice producing excess rat growth hormone
Hajdu, I., Obál, F., Fang, J., Krueger, J. M., & Rollo, C. D. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00485.2001 · Cited by 46 · see citing works
Self-citationEvidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats.
Matsumura, H., Honda, K., Choi, W. S., Inoué, S., Sakai, T., & Hayaishi, O. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5666 · Cited by 46 · see citing works
Obál, F., Sáry, G., Alföldi, P., Rubicsek, G., & Obál, F. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90107-2 · Cited by 45 · see citing works
Characterization, Properties and Multivariate Functions of Delta-Sleep-Inducing Peptide (DSIP)
Schoenenberger, G. A. (2008) · European Neurology · doi:10.1159/000115711 · Cited by 43 · see citing works
Postdialysis fatigue: Lack of effect of a biocompatible membrane
Sklar, A. H., Beezhold, D. H., Newman, N., Hendrickson, T., & DREISBACH, A. (1998) · American Journal of Kidney Diseases · doi:10.1053/ajkd.1998.v31.pm9631846 · Cited by 43 · see citing works
Vigilance and EEG power in rats: effects of potent inhibitors of the neuronal nitric oxide synthase
Dzoljic, E. D., van Leeuwen, R., VRIES, R. D., & Dzoljic, M. (1997) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/pl00005028 · Cited by 42 · see citing works
Mitsugi, N., & Kimura, F. (2008) · Neuroendocrinology · doi:10.1159/000124165 · Cited by 42 · see citing works
Šušić, V., & Totic, S. (1989) · Metabolic Brain Disease · doi:10.1007/bf00999497 · Cited by 42 · see citing works
Strain Differences in the Somnogenic Effects of Interferon Inducers in Mice
Toth, L. A. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.1065 · Cited by 42 · see citing works
The somatotropic axis and sleep.
Obál, F., & Krueger, J. M. (2001) · PubMed · Cited by 41 · see citing works
Self-citationAntiserum to Growth Hormone Decreases Sleep in the Rat
Obál, F., Bodosi, B., Szilágyi, A., Kacsoh, B. Z., & Krueger, J. M. (2008) · Neuroendocrinology · doi:10.1159/000127213 · Cited by 41 · see citing works
Self-citationYamuy, J., Sampogna, S. L., & Chase, M. H. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02204-6 · Cited by 41 · see citing works
Mirmiran, M., Kruisbrink, J., Bos, N. P. A., van der Werf, D., & Boer, G. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)90516-1 · Cited by 41 · see citing works
Interleukin 1 alpha and an interleukin 1 beta fragment are somnogenic
Obál, F., Opp, M. R., Cady, A. B., Johannsen, L., Postlethwaite, A. E., Poppleton, H., Seyer, J. M., & Krueger, J. M. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.259.3.r439 · Cited by 41 · see citing works
Self-citationSleep-promoting material from human urine and its relation to factor S from brain
Krueger, J. M., Bacsik, J., & García-Arrarás, J. (1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.238.2.e116 · Cited by 41 · see citing works
Self-citationIntraperitoneal injection of cholecystokinin elicits sleep in rabbits
Kapás, L., Obál, F., Opp, M. R., Johannsen, L., & Krueger, J. M. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90589-g · Cited by 40 · see citing works
Self-citationMolecular mechanism of sleep regulation by prostaglandin D2
Urade, Y., Hayaishi, O., Matsumura, H., & Watanabe, K. (1996) · Journal of Lipid Mediators and Cell Signalling · doi:10.1016/0929-7855(96)01511-8 · Cited by 40 · see citing works
Systemic growth hormone does not affect human sleep
Kern, W. (1993) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.76.6.1428 · Cited by 39 · see citing works
Nitric oxide synthase inhibition reduces wakefulness
Dzoljic, M. R., & de Vries, R. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90055-8 · Cited by 39 · see citing works
Ribeiro, A. C. D. M., Gilligan, J. G., & Kapás, L. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.4.r1048 · Cited by 39 · see citing works
Electroencephalographic analysis of the sleep-inducing actions of cholecystokinin
Rojas-Ramírez, J. A., Crawley, J. N., & Mendelson, W. B. (1982) · Neuropeptides · doi:10.1016/0143-4179(82)90008-7 · Cited by 38 · see citing works
Spontaneous activity, sleep, and body temperature in rats lacking the CCK-A receptor
Sei, M., Sei, H., & Shima, K. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00146-8 · Cited by 38 · see citing works
Endogenous and exogenous factors on sleep–wake cycle regulation
García‐García, F., & Drucker-Colı́n, R. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00086-0 · Cited by 38 · see citing works
Drucker-Colı́n, R. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00008-h · Cited by 37 · see citing works
Nerve growth factor enhances sleep in rabbits
Takahashi, S., & Krueger, J. M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00196-2 · Cited by 36 · see citing works
Self-citationBoth CCK-A and CCK-B/gastrin receptors are present on rabbit vagus nerve
Lin, C., & Miller, T. R. (1992) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1992.263.3.r591 · Cited by 36 · see citing works
Somatostatin antiserum blocks carbachol-induced increase of paradoxical sleep in the rat
Danguir, J., & de Saint-Hilaire-Kafi, S. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90003-2 · Cited by 35 · see citing works
Sleep deprivation increases rat hypothalamic growth hormone-releasing hormone mRNA
Zhang, J., Chen, Z., Taishi, P., Obál, F., Fang, J., & Krueger, J. M. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.6.r1755 · Cited by 33 · see citing works
Self-citationMarshall, L., Derad, I., Strasburger, C. J., Fehm, H. L., & Jan Born, A. (1999) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00085-7 · Cited by 33 · see citing works
Interleukin‐1 induces sleep‐like behavior and alters call structure in juvenile rhesus macaques
Friedman, E. M., Boinski, S., & Coe, C. L. (1995) · American Journal of Primatology · doi:10.1002/ajp.1350350207 · Cited by 33 · see citing works
Flagged first, then by citations
Research works printed but not linked: 9
- Uchizono K, Higashi A, Iriki M, Nagasaki H, Ishikawa M, Komoda Y, Inoué S & Honda K: Sleep- promoting fractions obtained from the brain-stem of sleep-deprived rats. In:Eds: Ito M, Kubota K, Tsukahara N, Yagi K, Intergative control functions of the brain vol.I. Amstredam,New York,Oxford: Elsevier/North- Holland Biomedical Press, 1978:392-396
- Drucker-Colin R, Prospero-Garcia O, Arankowsky- Sandoval G & Perez-Montfort R: Gastropancreatic peptides and sensory stimuli as REM factors. In:Eds: Inoué S, Schneider-Helmert D, Sleep peptides: basic and clinical approaches. Berlin: Springer, 1988:73-94
- Kaushal N, B.Johansson, L.Halldner, B.Fredholm & R.W.Greene: Reduced slow wave activity in the adenosine A1 receptor knockout mice. Soc for Neurosci Absts 27, 1378 (2001)
- Franken P, P.Gip, G.Hagiwara & H.C.Heller: Brain glycogen content in inbred mice: effects of strain, sleep loss, and brain structure. Soc for Neurosci Absts 27, 1381 (2001)
- Gardi J, P.Taishi, R.Speth, F.Obal, Jr. & J.M.Krueger: Sleep deprivation alters hypothalamic growth hormone-releasing hormone mRNA and binding sites. Neurosci Lett in press, (2002) 131.
- Alam N, D.McGinty, L.Imeri, M.Opp & R.Szymusiak: Effects of interleukin-1 beta on sleep-and wake-related preoptic anterior hypothalamic neurons in unrestrained rats. Sleep 24, A59 (2001) 143.
- Imeri L, S.Bianchi, M.Mariotti & M.R.Opp: Interleukin-1 microinjected into the dorsal raphe nucleus enhances NREMS in rats. J Sleep Res 11, 107 (2002) 214.
- Veasey SC, M.Mackiewicz, P.Fenik, M.Ro, M.D.Oglivie & A.L.Pack: IL1 beta knockout mice lack the TNF alpha response to sleep deprivation but have normal sleep and sleep recovery. Soc Neurosci Abst 23, 792 (1997) 255.
- Taishi P, J.Gardi, Z.Chen, J.Fang & J.M.Krueger: Sleep deprivation increases the expression of TNF alpha mRNA and TNF 55kD receptor mRNA in rat brain. The Physiologist 42, A4 (1999) 256.
Cited by
Sorted by citations
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works
How (and why) the immune system makes us sleep
Imeri, L., & Opp, M. R. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2576 · Cited by 710 · see citing works
Sleep health: Reciprocal regulation of sleep and innate immunity
Irwin, M. R., & Opp, M. R. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.148 · Cited by 624 · see citing works
Sleep as a fundamental property of neuronal assemblies
Krueger, J. M., Rector, D. M., Roy, S., Van Dongen, H. P. A., Belenky, G., & Panksepp, J. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2521 · Cited by 596 · see citing works
Self-citationThe Role of Cytokines in Sleep Regulation
Krueger, J. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786549281 · Cited by 507 · see citing works
Self-citationSleep function: Toward elucidating an enigma
Krueger, J. M., Frank, M. G., Wisor, J. P., & Roy, S. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.08.005 · Cited by 440 · see citing works
Self-citationOpp, M. R. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.01.002 · Cited by 393 · see citing works
Gut microbiome diversity is associated with sleep physiology in humans
Smith, R. P., Easson, C., Lyle, S. M., Kapoor, R., Donnelly, C. P., Davidson, E. J., Parikh, E., Lopez, J. V., & Tartar, J. L. (2019) · PLOS ONE · doi:10.1371/journal.pone.0222394 · Cited by 390 · see citing works
Sleep and the single neuron: the role of global slow oscillations in individual cell rest
Vyazovskiy, V. V., & Harris, K. D. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3494 · Cited by 362 · see citing works
Sleep and circadian rhythms: key components in the regulation of energy metabolism
Laposky, A. D., Bass, J., Kohsaka, A., & Turek, F. W. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.06.079 · Cited by 351 · see citing works
Han, K.-S., Kim, L., & Shim, I. (2012) · Experimental Neurobiology · doi:10.5607/en.2012.21.4.141 · Cited by 290 · see citing works
Bodosi, B., Gardi, J., Hajdu, I., Szentirmai, É., Obál, F., & Krueger, J. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00294.2004 · Cited by 304 · see citing works
Self-citation<i>Hypothalamic Regulation of Sleep and Arousal</i>
Szymusiak, R., & McGinty, D. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.027 · Cited by 294 · see citing works
Datta, S., & MacLean, R. R. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.02.004 · Cited by 296 · see citing works
Sleep homeostasis: a role for adenosine in humans?
Landolt, H.-P. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.02.024 · Cited by 290 · see citing works
Links between the innate immune system and sleep
Majde, J. A., & Krueger, J. M. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.08.005 · Cited by 277 · see citing works
Self-citationSleep Neurobiology from a Clinical Perspective
España, R. A., & Scammell, T. E. (2011) · SLEEP · doi:10.5665/sleep.1112 · Cited by 282 · see citing works
Caffeine Attenuates Waking and Sleep Electroencephalographic Markers of Sleep Homeostasis in Humans
Landolt, H., Rétey, J., Tönz, K., Gottselig, J. M., Khatami, R., Buckelmüller, I., & Achermann, P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300526 · Cited by 211 · see citing works
Gallopin, T., Luppi, P., Cauli, B., Urade, Y., Rossier, J., Hayaishi, O., Lambolez, B., & Fort, P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.045 · Cited by 211 · see citing works
Involvement of Ca2+-Dependent Hyperpolarization in Sleep Duration in Mammals
Tatsuki, F., Sunagawa, G. A., Shi, S., Susaki, E. A., Yukinaga, H., Perrin, D., Sumiyama, K., Ukai‐Tadenuma, M., Fujishima, H., Ohno, R.-I., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.032 · Cited by 196 · see citing works
Molecular links between endocrine, nervous and immune system during chronic stress
Zefferino, R., Di Gioia, S., & Conese, M. (2021) · Brain and Behavior · doi:10.1002/brb3.1960 · Cited by 204 · see citing works
Altered sleep regulation in leptin-deficient mice
Laposky, A. D., Shelton, J., Bass, J., Dugovic, C., Perrino, N., & Turek, F. W. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00304.2005 · Cited by 203 · see citing works
Physiology of psychoneuroimmunology: A personal view
Besedovsky, H. O., & Rey, A. D. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.09.008 · Cited by 202 · see citing works
Szymusiak, R. S., Gvilia, I., & McGinty, D. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.03.013 · Cited by 200 · see citing works
Insufficient Sleep Reversibly Alters Bidirectional Synaptic Plasticity and NMDA Receptor Function
Kopp, C., Longordo, F., Nicholson, J. R., & Lüthi, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2702-06.2006 · Cited by 192 · see citing works
The importance of ‘awareness’ for understanding fetal pain
Mellor, D. J., Diesch, T., Gunn, A. J., & Bennet, L. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.01.006 · Cited by 189 · see citing works
CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids
Garaulet, M., Lee, Y.-C., Shen, J., Parnell, L. D., Arnett, D. K., Tsai, M. Y., Lai, C.-Q., & Ordovas, J. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27536 · Cited by 172 · see citing works
Cytokines and pathological sleep
Kapsimalis, F., Basta, M., Varouchakis, G., Gourgoulianis, K. I., Vgontzas, A. N., & Kryger, M. H. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.08.019 · Cited by 170 · see citing works
Obál, F., & Krueger, J. M. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.03.005 · Cited by 166 · see citing works
Self-citationHumoral Links between Sleep and the Immune System
Krueger, J. M., & Majde, J. A. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03133.x · Cited by 163 · see citing works
Self-citationBiochemical Regulation of Sleep and Sleep Biomarkers
Clinton, J. M., Davis, C. J., Zielinski, M. R., Jewett, K. A., & Krueger, J. M. (2011) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.1360 · Cited by 159 · see citing works
Self-citationMolecular Mechanisms of Sleep Homeostasis in Flies and MammalsPreprint
Allada, R., Cirelli, C., & Sehgal, A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027730 · Cited by 155 · see citing works
Neuroanatomy and neurochemistry of sleep
Stenberg, D. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6530-3 · Cited by 151 · see citing works
Kapsimalis, F., Richardson, G. S., Opp, M. R., & Kryger, M. H. (2005) · Current Opinion in Pulmonary Medicine · doi:10.1097/01.mcp.0000183062.98665.6b · Cited by 150 · see citing works
Alternating vigilance states: new insights regarding neuronal networks and mechanisms
Fort, P., Bassetti, C. L., & Luppi, P. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06722.x · Cited by 148 · see citing works
Sleep, recovery, and metaregulation: explaining the benefits of sleep
Vyazovskiy, V. V. (2015) · Nature and Science of Sleep · doi:10.2147/nss.s54036 · Cited by 151 · see citing works
Interleukin‐1β: a bridge between inflammation and excitotoxicity?
Fogal, B., & Hewett, S. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05315.x · Cited by 145 · see citing works
Molecular Mechanisms of Cancer-Induced Sleep Disruption
Walker, W. H., II, & Borniger, J. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112780 · Cited by 146 · see citing works
Homeostatic Regulation of Sleep: A Role for Preoptic Area Neurons
Gvilia, I., Xu, F., McGinty, D., & Szymusiak, R. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2012-06.2006 · Cited by 145 · see citing works
Measurement of endogenous acetone and isoprene in exhaled breath during sleep
King, J., Kupferthaler, A., Frauscher, B., Hackner, H., Unterkofler, K., Teschl, G., Hinterhuber, H., Amann, A., & Högl, B. (2012) · Physiological Measurement · doi:10.1088/0967-3334/33/3/413 · Cited by 144 · see citing works
Everson, C. A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00021.2005 · Cited by 141 · see citing works
Steiger, A. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01175.x · Cited by 137 · see citing works
Cytokines in immune function and sleep regulation
Krueger, J. M., Majde, J. A., & Rector, D. M. (2010) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52006-7.00015-0 · Cited by 133 · see citing works
Self-citationReciprocal interactions between the GH axis and sleep
Cauter, E. V., Latta, F., Nedeltcheva, A. V., Spiegel, K., Leproult, R., Vandenbril, C., Weiss, R. E., Mockel, J., Legros, J.-J., & Copinschi, G. (2004) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2004.03.006 · Cited by 135 · see citing works
Neuronal activity in the preoptic hypothalamus during sleep deprivation and recovery sleep
Alam, A., Kumar, S., McGinty, D., Alam, M. N., & Szymusiak, R. S. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00504.2013 · Cited by 134 · see citing works
Slow-Wave Activity Enhancement to Improve Cognition
Wilckens, K. A., Ferrarelli, F., Walker, M. P., & Buysse, D. J. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.03.003 · Cited by 136 · see citing works
Ruiz, F. S., Andersen, M. L., Martins, R. C., Zager, A., Lopes, J. D., & Tufik, S. (2012) · Innate Immunity · doi:10.1177/1753425910385962 · Cited by 132 · see citing works
Dossena, S., Imeri, L., Mangieri, M., Garofoli, A., Ferrari, L. L., Senatore, A., Restelli, E., Balducci, C., Fiordaliso, F., Salio, M., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.008 · Cited by 131 · see citing works
Krueger, J. M., Rector, D. M., & Churchill, L. (2007) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2007.03.003 · Cited by 127 · see citing works
Self-citationInteraction Between Sleep and the Immune Response in Drosophila: A Role for the NFκB Relish
Williams, J. A., Sathyanarayanan, S., Hendricks, J. C., & Sehgal, A. (2007) · Sleep · doi:10.1093/sleep/30.4.389 · Cited by 126 · see citing works
Involvement of cytokines in slow wave sleep
Krueger, J. M., Clinton, J. M., Winters, B. D., Zielinski, M. R., Taishi, P., Jewett, K. A., & Davis, C. J. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00003-x · Cited by 126 · see citing works
Self-citationIdentifying Sleep Regulatory Genes Using a Drosophila Model of Insomnia
Seugnet, L., Suzuki, Y., Thimgan, M. S., Donlea, J. M., Gimbel, S. I., Gottschalk, L., Duntley, S. P., & Shaw, P. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5629-08.2009 · Cited by 126 · see citing works
Sleep waking and neurobehavioural performance
Rogers, N. L. (2003) · Frontiers in bioscience · doi:10.2741/1174 · Cited by 125 · see citing works
Influences of Allergic Rhinitis on Sleep
Ferguson, B. J. (2004) · Otolaryngology–Head and Neck Surgery · doi:10.1016/j.otohns.2004.02.001 · Cited by 124 · see citing works
Sleep quality and disease severity in patients with chronic rhinosinusitis
Alt, J. A., Smith, T. L., Mace, J. C., & Soler, Z. M. (2013) · The Laryngoscope · doi:10.1002/lary.24040 · Cited by 147 · see citing works
The Sleep-Immunity Relationship
Gamaldo, C. E., Shaikh, A. K., & McArthur, J. C. (2012) · Neurologic Clinics · doi:10.1016/j.ncl.2012.08.007 · Cited by 124 · see citing works
Morris, G., Stubbs, B., Köhler, C. A., Walder, K. R., Slyepchenko, A., Berk, M., & Carvalho, A. F. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.03.007 · Cited by 122 · see citing works
Sleeping to fuel the immune system: mammalian sleep and resistance to parasites
Opp, M. R. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-8 · Cited by 120 · see citing works
Mascetti, G. G. (2016) · Nature and Science of Sleep · doi:10.2147/nss.s71970 · Cited by 119 · see citing works
A neuro-immune model of myalgic encephalomyelitis/chronic fatigue syndrome
Morris, G., & Maes, M. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-012-9324-8 · Cited by 117 · see citing works
Sleep and autonomic nervous system
Zoccoli, G., & Amici, R. (2020) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.01.002 · Cited by 114 · see citing works
Kuo, T., Pike, D. H., Beizaeipour, Z., & Williams, J. A. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-17 · Cited by 110 · see citing works
Alam, M. N., McGinty, D., Bashir, T., Kumar, S., Imeri, L., Opp, M. R., & Szymusiak, R. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03469.x · Cited by 108 · see citing works
Delta Wave Power: An Independent Sleep Phenotype or Epiphenomenon?
Davis, C. J., Clinton, J. M., Jewett, K. A., Zielinski, M. R., & Krueger, J. M. (2011) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.1346 · Cited by 106 · see citing works
Self-citationMartı́nez-González, D., Lesku, J. A., & Rattenborg, N. C. (2008) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00636.x · Cited by 105 · see citing works
Invited review: MDP and other muropeptides — direct and synergistic effects on the immune system
Traub, S., von Aulock, S., Härtung, T., & Hermann, C. (2006) · Journal of Endotoxin Research · doi:10.1179/096805106x89044 · Cited by 115 · see citing works
Garaulet, M., Lee, Y.-C., Shen, J., Parnell, L. D., Arnett, D. K., Tsai, M. Y., Lai, C.-Q., & Ordovas, J. M. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.176 · Cited by 101 · see citing works
Cellular and chemical neuroscience of mammalian sleep
Datta, S. (2010) · Sleep Medicine · doi:10.1016/j.sleep.2010.02.002 · Cited by 100 · see citing works
FMRFamide signaling promotes stress-induced sleep in Drosophila
Lenz, O., Xiong, J., Nelson, M. D., Raizen, D. M., & Williams, J. A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.12.028 · Cited by 98 · see citing works
Churchill, L., Rector, D. M., Yasuda, K., Fix, C. F., Rojas, M. J., Yasuda, T., & Krueger, J. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.066 · Cited by 93 · see citing works
Self-citationHumoral Sleep Regulation; Interleukin-1 and Tumor Necrosis Factor
Jewett, K. A., & Krueger, J. M. (2012) · Vitamins and hormones · doi:10.1016/b978-0-12-394623-2.00013-5 · Cited by 91 · see citing works
Self-citationState-specific asymmetries in EEG slow wave activity induced by local application of TNFα
Yoshida, H., Peterfi, Z., García‐García, F., Kirkpatrick, R. J., Yasuda, T., & Krueger, J. M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.02.055 · Cited by 90 · see citing works
Self-citationChronic rhinosinusitis and sleep: a contemporary review
Alt, J. A., & Smith, T. L. (2013) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21217 · Cited by 90 · see citing works
ATP and the purine type 2 X7 receptor affect sleep
Krueger, J. M., Taishi, P., De, A., Davis, C. J., Winters, B. D., Clinton, J. M., Szentirmai, É., & Zielinski, M. R. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00586.2010 · Cited by 89 · see citing works
Self-citationTNF-α and Temporal Changes in Sleep Architecture in Mice Exposed to Sleep Fragmentation
Kaushal, N., Ramesh, V., & Gozal, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045610 · Cited by 90 · see citing works
Alt, J. A., Smith, T. L., Schlosser, R. J., Mace, J. C., & Soler, Z. M. (2014) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21364 · Cited by 86 · see citing works
The sleep relay—the role of the thalamus in central and decentral sleep regulation
Coulon, P., Budde, T., & Pape, H. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1014-6 · Cited by 86 · see citing works
Neuropeptidergic control of sleep and wakefulness
Richter, C., Woods, I. G., & Schier, A. F. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150447 · Cited by 75 · see citing works
Peterfi, Z., Churchill, L., Hajdu, I., Obál, F., Krueger, J. M., & Párducz, Á. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.10.047 · Cited by 76 · see citing works
Self-citationChurchill, L., Taishi, P., Wang, M., Brandt, J. A., Cearley, C. N., Rehman, A., & Krueger, J. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.083 · Cited by 76 · see citing works
Self-citationSleep, immunity and shift workers: A review
de Almeida, C. M. O., & Malheiro, A. (2016) · Sleep Science · doi:10.1016/j.slsci.2016.10.007 · Cited by 76 · see citing works
Mealtime: A circadian disruptor and determinant of energy balance?
Ruddick-Collins, L. C., Morgan, P. J., & Johnstone, A. M. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12886 · Cited by 74 · see citing works
Behavioral and Electrophysiological Correlates of Sleep and Sleep Homeostasis
Deboer, T. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_248 · Cited by 73 · see citing works
Interaction between sleep quality and dietary inflammation on frailty: NHANES 2005–2008
Sun, M., Wang, L., Wang, X., Li, T., Fang, J., Wang, Y., Yang, Y., & Li, B. (2022) · Food & Function · doi:10.1039/d2fo01832b · Cited by 72 · see citing works
Brambilla, D., Franciosi, S., Opp, M. R., & Imeri, L. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05796.x · Cited by 72 · see citing works
Vienne, J., Lecciso, G., Constantinescu, I., Schwartz, S., Franken, P., Heinzer, R., & Tafti, M. (2012) · Sleep · doi:10.5665/sleep.1992 · Cited by 72 · see citing works
García‐García, F., Juárez‐Aguilar, E., Santiago-Garcı́a, J., & Cardinali, D. P. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.04.003 · Cited by 71 · see citing works
Role of cytokines in atypical depression
Yoon, H.-K., Kim, Y.-K., Lee, H.-J., Kwon, D.-Y., & Kim, L. (2012) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2011.611894 · Cited by 65 · see citing works
Pharmacologic approaches to daytime and nighttime symptoms of allergic rhinitis
Storms, W. W. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.08.045 · Cited by 65 · see citing works
Neuroscience-driven discovery and development of sleep therapeutics
Dresler, M., Spoormaker, V. I., Beitinger, P., Czisch, M., Kimura, M., Steiger, A., & Holsboer, F. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.012 · Cited by 63 · see citing works
Radiation-Induced Neuroinflammation and Radiation Somnolence Syndrome
Ballesteros‐Zebadúa, P., Chavarría, A., Celis, M. A., Paz, C., & Franco‐Pérez, J. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311201070937 · Cited by 59 · see citing works
Momiyama, T., & Záborszky, L. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00507.2005 · Cited by 59 · see citing works
Time of day differences in IL1β and TNFα mRNA levels in specific regions of the rat brain
Cearley, C., Churchill, L., & Krueger, J. M. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.07.019 · Cited by 58 · see citing works
Self-citationBirth and hatching: Key events in the onset of awareness in the lamb and chick
Mellor, D. J., & Diesch, T. J. (2007) · New Zealand Veterinary Journal · doi:10.1080/00480169.2007.36742 · Cited by 58 · see citing works
Rodgers, J. (2009) · Parasitology · doi:10.1017/s0031182009991806 · Cited by 57 · see citing works
Picchioni, D., Reith, R. M., Nadel, J., & Smith, C. B. (2014) · Brain Sciences · doi:10.3390/brainsci4010150 · Cited by 55 · see citing works
TNFα siRNA Reduces Brain TNF and EEG Delta Wave Activity in Rats
Taishi, P., Churchill, L., Wang, M., Kay, D., Davis, C. J., Guan, X., De, A., Yasuda, T., Liao, F., & Krueger, J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.04.072 · Cited by 54 · see citing works
Self-citationNadjar, A., Wigren, H., & Tremblay, M. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00250 · Cited by 56 · see citing works
Langmesser, S., Franken, P., Feil, S. C., Emmenegger, Y., Albrecht, U., & Feil, R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004238 · Cited by 55 · see citing works
Wiater, M. F., Mukherjee, S., Li, A.-J., Dinh, T. T. N., Rooney, E., Simasko, S. M., & Ritter, S. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00168.2011 · Cited by 55 · see citing works
- Authors
- Krueger, J. M.
- Affiliations
- Washington State University (US)
- Corresponding author
- Krueger, James M
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2003
- Volume
- 8
- Issue
- 4
- Pages
- d520-550
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/1033
- OpenAlex
- W2020287085
- Cited by
- 329
- References
- 242
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 4 · 2020: 7 · 2019: 12 · 2018: 11 · 2017: 10 · 2016: 17 · 2015: 10 · 2014: 10 · 2013: 22 · 2012: 17
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in bioscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Hungarian Scientific Research Fund
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS-27250, NS-31453, NS-25378, R01NS031453, R01NS027250, R01NS025378)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-36520, R01HD036520)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- NREM sleep, sleep regulation, sleep factors, adenosine, prostaglandin D2, growth hormone-releasing hormone, interleukin-1, TNF-α, delta sleep-inducing peptide, uridine, glutathione disulfide, muramyl peptides, hypothalamus, preoptic area, basal forebrain, oleamide, cortistatin, cholecystokinin, insulin, nitric oxide, sleep-wake behavior
- MeSH terms
- Animals, Humans, Sleep, REM
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
