Neural circuitry engaged by prostaglandins during the sickness syndrome
Open accessAbstract
During illnesses caused by infectious disease or other sources of inflammation, a suite of brain-mediated responses called the sickness syndrome occurs, which includes fever, anorexia, sleepiness, hyperalgesia and elevated corticosteroid secretion. Much of the sickness syndrome is mediated by prostaglandins acting on the brain and can be prevented by nonsteroidal anti-inflammatory drugs, such as aspirin or ibuprofen, that block prostaglandin synthesis. By examining which prostaglandins are produced at which sites and how they interact with the nervous system, researchers have identified specific neural circuits that underlie the sickness syndrome.
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All these pathways may induce microglial activation and neuroinflammation in response to peripheral inflammation, thereby initiating CNS responses including fever and sickness behavior.
“All these pathways may induce microglial activation and neuroinflammation in response to peripheral inflammation, thereby initiating CNS responses including fever and sickness behavior (486, 493).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [486]
The MnPO is an important part of the thermoregulatory pathways.
“The MnPO has recently been shown to be an important part of the thermoregulatory pathways (Nakamura and Morrison, 2010; Saper et al., 2012).”
From Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: A novel hypothesis on the mechanism of hot flushes (2013) · cites this paper as Saper et al., 2012
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- Authors
- Saper, C. B., Romanovsky, A. A., & Scammell, T. E.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- St. Joseph's Hospital and Medical Center (US)
- Corresponding author
- Saper, Clifford B
- Venue
- Nature Neuroscience
- Published
- 2012-07-26
- Volume
- 15
- Issue
- 8
- Pages
- 1088-1095
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3748818
- OpenAlex
- W1993258961
- Cited by
- 285
- References
- 102
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 26 · 2023: 22 · 2022: 15 · 2021: 23 · 2020: 26 · 2019: 22 · 2018: 25 · 2017: 19 · 2016: 16 · 2015: 24 · 2014: 24 · 2013: 15
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P01HL095491, HL095491)
- National Institute of Neurological Disorders and Stroke (R01NS041233, R01NS055367, NS41233, R01NS072337, NS 072337, NS-055367)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- sickness behavior, prostaglandins, fever, anorexia, sleepiness, hyperalgesia, corticosteroid secretion, nonsteroidal anti-inflammatory drugs, aspirin, ibuprofen, neural circuits, inflammation
- MeSH terms
- Anti-Inflammatory Agents, Non-Steroidal, Fever, Humans, Inflammation, Prostaglandins, Syndrome
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