The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation.
Open accessAbstract
The gene encoding latent-infection membrane protein 1 (LMP1) was specifically mutated in Epstein-Barr virus (EBV) recombinants by inserting a nonsense linker after codon 9 or codon 84 or into an intron 186 bp 3' to the latter insertion site. EBV recombinants with the LMP1 intron mutation were wild type for LMP1 expression and for growth transformation of primary B lymphocytes. In contrast, EBV recombinants with the mutations in the LMP1 open reading frame expressed N-terminally truncated crossreactive proteins and could initiate or maintain primary B-lymphocyte transformation only when wild-type LMP1 was provided in trans by a coinfecting, transformation-defective EBV, P3HR-1. These data indicate that LMP1 is essential for EBV-mediated transformation of primary B lymphocytes, that the first 43 amino acids are critical for LMP1's function, and that codon 44-initiated LMP1 does not have a dominant negative effect on transformation.
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Cites
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Cited by
Epstein-Barr virus-associated Hodgkin's disease: Epidemiologic characteristics in international data
Glaser, S. L., Lin, R. J., Stewart, S. L., Ambinder, R. F., Jarrett, R. F., Brousset, P., Pallesen, G., Gulley, M. L., Khan, G., O'Grady, J., et al. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970207)70:4<375::aid-ijc1>3.0.co;2-t · Cited by 506
Latent membrane protein 1of Epstein-Barr virus mimics a constitutively active receptor molecule
Gires, O. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6131 · Cited by 451
Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses
Uchida, J., Yasui, T., Takaoka-Shichijo, Y., Muraoka, M., Kulwichit, W., Raab-Traub, N., & Kikutani, H. (1999) · Science · doi:10.1126/science.286.5438.300 · Cited by 437
Kulwichit, W., Edwards, R. H., Davenport, E. M., Baskar, J. F., Godfrey, V., & Raab-Traub, N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11963 · Cited by 414
Epstein–Barr virus latent genes
Kang, M.-S., & Kieff, E. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.84 · Cited by 361
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Metadata
- Authors
- Kaye, K. M., Izumi, K. M., & Kieff, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-10
- Volume
- 90
- Issue
- 19
- Pages
- 9150-9154
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079199354
- Cited by
- 762
- References
- 1
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Kaye, K. M., Izumi, K. M., & Kieff, E. (1993). Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.19.9150
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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