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Atrial G protein-activated K+ channel: expression cloning and molecular properties.
Open accessAbstract
Activity of several ion channels is controlled by heterotrimeric GTP-binding proteins (G proteins) via a membrane-delimited pathway that does not involve cytoplasmic intermediates. The best studied example is the K+ channel activated by muscarinic agonists in the atrium, which plays a crucial role in regulating the heartbeat. To enable studies of the molecular mechanisms of activation, this channel, denoted KGA, was cloned from a rat atrium cDNA library by functional coupling to coexpressed serotonin type 1A receptors in Xenopus oocytes. KGA displays regions of sequence homology to other inwardly rectifying channels as well as unique regions that may govern G-protein interaction. The expressed KGA channel is activated by serotonin 1A, muscarinic m2, and delta-opioid receptors via G proteins. KGA is activated by guanosine 5'-[gamma-thio]triphosphate in excised patches, confirming activation by a membrane-delimited pathway, and displays a conductance equal to that of the endogenous channel in atrial cells. The hypothesis that similar channels play a role in neuronal inhibition is supported by the cloning of a nearly identical channel (KGB1) from a rat brain cDNA library.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
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Inagaki, N., Gonoi, T., Clement, J. P., Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S., & Bryan, J. (1995) · Science · doi:10.1126/science.270.5239.1166 · Cited by 1,709
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Molecular Diversity of K+ Channels
COETZEE, W. A., AMARILLO, Y., CHIU, J., CHOW, A., LAU, D., McCORMACK, T., MORENA, H., NADAL, M. S., OZAITA, A., POUNTNEY, D., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11293.x · Cited by 1,095
Wang, W., Whorton, M. R., & MacKinnon, R. (2014) · eLife · doi:10.7554/elife.03671 · Cited by 448
Self-citationSignalling Via the G Protein-Activated K+ Channels
Dascal, N. (1997) · Cellular Signalling · doi:10.1016/s0898-6568(97)00095-8 · Cited by 310
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Metadata
- Authors
- Dascal, N., Schreibmayer, W., Lim, N. F., Wang, W., Chavkin, C., DiMagno, L., Labarca, C., Kieffer, B. L., Gaveriaux-Ruff, C., & Trollinger, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-11
- Volume
- 90
- Issue
- 21
- Pages
- 10235-10239
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2043327777
- Cited by
- 358
- References
- 1
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Dascal, N., Schreibmayer, W., Lim, N. F., Wang, W., Chavkin, C., DiMagno, L., Labarca, C., Kieffer, B. L., Gaveriaux-Ruff, C., & Trollinger, D. (1993). Atrial G protein-activated K+ channel: expression cloning and molecular properties. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.21.10235
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