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Complex synthetic chemical libraries indexed with molecular tags.
Open accessAbstract
Combinatorial methods of chemical synthesis allow the creation of molecular libraries having immense diversity. The utility of such libraries is dependent upon identifying the structures of the molecules so prepared. We describe the construction of a peptide combinatorial library, having 117,649 different members, synthesized on beads and indexed with inert chemical tags. These tags are used as a binary code to record the reaction history of each bead. The code can be read directly from a single bead by electron capture capillary gas chromatography. We demonstrate the correct selection of members of the library on the basis of binding to a monoclonal antibody.
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Cites
Encoded combinatorial chemistry.
Brenner, S., & Lerner, R. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5381 · Cited by 1,014
Cited by
Organic Chemistry on Solid Supports
Früchtel, J. S., & Jung, G. (1996) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199600171 · Cited by 648
DNA-encoded chemistry: enabling the deeper sampling of chemical space
Goodnow, R. A., Dumelin, C. E., & Keefe, A. D. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.213 · Cited by 621
Linkers and Cleavage Strategies in Solid-Phase Organic Synthesis and Combinatorial Chemistry
Guillier, F., Orain, D., & Bradley, M. (2000) · Chemical Reviews · doi:10.1021/cr980040+ · Cited by 516
Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library
Liang, R., Yan, L., Loebach, J., Ge, M., Uozumi, Y., Sekanina, K., Horan, N., Gildersleeve, J., Thompson, C., Smith, A., et al. (1996) · Science · doi:10.1126/science.274.5292.1520 · Cited by 277
Self-citationNi, D., Lu, S., & Zhang, J. (2019) · Medicinal Research Reviews · doi:10.1002/med.21585 · Cited by 116
Metadata
- Authors
- Ohlmeyer, M. H., Swanson, R. N., Dillard, L. W., Reader, J. C., Asouline, G., Kobayashi, R., Wigler, M., & Still, W. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-12
- Volume
- 90
- Issue
- 23
- Pages
- 10922-10926
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2094850820
- Cited by
- 445
- References
- 1
- FWCI
- 11.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Ohlmeyer, M. H., Swanson, R. N., Dillard, L. W., Reader, J. C., Asouline, G., Kobayashi, R., Wigler, M., & Still, W. C. (1993). Complex synthetic chemical libraries indexed with molecular tags. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.23.10922
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
