The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice.
Open accessAbstract
Murine lung epithelial (MLE) cell lines representing the distal bronchiolar and alveolar epithelium were produced from lung tumors generated in transgenic mice harboring the viral oncogene simian virus 40 (SV40) large tumor antigen under transcriptional control of a promoter region from the human surfactant protein C (SP-C) gene. The cell lines exhibited rapid growth, lack of contact inhibition, and an epithelial cell morphology for 30-40 passages in culture. Microvilli, cytoplasmic multivesicular bodies, and multilamellar inclusion bodies (morphologic characteristics of alveolar type II cells) were detected in some of the MLE cell lines by electron microscopic analysis. The MLE cells also maintained functional characteristics of distal respiratory epithelial cells including the expression of surfactant proteins and mRNAs and the ability to secrete phospholipids. Expression of the exogenous SV40 large tumor antigen gene was detected in all of the generated cell lines. The SP-C/SV40 large tumor antigen transgenic mice and the MLE cell lines will be useful for the study of pulmonary surfactant production and regulation as well as lung development and tumorigenesis.
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Cites
Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome.
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Self-citationCell Lines of the Pituitary Gonadotrope Lineage Derived by Targeted Oncogenesis in Transgenic Mice
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Function and regulation of expression of pulmonary surfactant-associated proteins
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Self-citationWhitehead, R. H., VanEeden, P. E., Noble, M. D., Ataliotis, P., & Jat, P. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.587 · Cited by 364
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Surfactant-associated protein inhibits phospholipid secretion from type II cells
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Cited by
Schmidt, E. P., Yang, Y., Janssen, W. J., Gandjeva, A., Perez, M. J., Barthel, L., Zemans, R. L., Bowman, J. C., Koyanagi, D. E., Yunt, Z. X., et al. (2012) · Nature Medicine · doi:10.1038/nm.2843 · Cited by 848
Varma, S., Cao, Y., Tagne, J.-B., Lakshminarayanan, M., Li, J., Friedman, T. B., Morell, R. J., Warburton, D., Kotton, D. N., & Ramirez, M. I. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.408401 · Cited by 79
Sato, T., Shimizu, T., Fujita, H., Imai, Y., Drucker, D. J., Seino, Y., & Yamada, Y. (2020) · Endocrinology · doi:10.1210/endocr/bqaa201 · Cited by 29
Metadata
- Authors
- Wikenheiser, K. A., Vorbroker, D. K., Rice, W. R., Clark, J. C., Bachurski, C. J., Oie, H. K., & Whitsett, J. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-12
- Volume
- 90
- Issue
- 23
- Pages
- 11029-11033
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1999468126
- Cited by
- 358
- References
- 19
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Wikenheiser, K. A., Vorbroker, D. K., Rice, W. R., Clark, J. C., Bachurski, C. J., Oie, H. K., & Whitsett, J. A. (1993). Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.23.11029
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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