The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Cell Lines of the Pituitary Gonadotrope Lineage Derived by Targeted Oncogenesis in Transgenic Mice
Open accessAbstract
Study of the molecular and cellular biology of the gonadotropin hormones would be greatly facilitated by the availability of immortalized anterior pituitary gonadotrope cell lines. We directed expression of the simian virus-40 (SV40) T-antigen (Tag) oncogene to specific cells in the anterior pituitary of transgenic mice using the promoter/enhancer region from the human glycoprotein hormone alpha-subunit gene. Transgenic mice carrying this fusion gene developed anterior pituitary tumors. Clonal cell lines established from these tumors express the endogenous mouse alpha-subunit gene and synthesize and secrete alpha-subunit protein. However, they do not express beta-subunit genes. Alpha-subunit mRNA is induced by GnRH in a dose- and time-dependent manner, but is not regulated by TRH. Thus, we have targeted tumorigenesis in transgenic mice to anterior pituitary cells of the gonadotrope lineage to immortalize this specific endocrine cell while maintaining several highly differentiated functions unique to gonadotropes.
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Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A. E., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,725
Glycoprotein Hormones: Structure and Function
Pierce, J. G., & Parsons, T. F. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.002341 · Cited by 2,294
Hybridization of nucleic acids immobilized on solid supports
Meinkoth, J., & Wahl, G. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90808-x · Cited by 1,324
Hanahan, D. (1985) · Nature · doi:10.1038/315115a0 · Cited by 1,281
Establishment of Clonal Strains of Rat Pituitary Tumor Cells That Secrete Growth Hormone1,2
TASHJIAN, A. H., YASUMURA, Y., LEVINE, L., SATO, G. H., & PARKER, M. L. (1968) · Endocrinology · doi:10.1210/endo-82-2-342 · Cited by 678
Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone
Seeburg, P. H., Shine, J., Martial, J. A., Baxter, J. D., & Goodman, H. M. (1977) · Nature · doi:10.1038/270486a0 · Cited by 528
Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.
Efrat, S., Linde, S., Kofod, H., Spector, D., Delannoy, M., Grant, S., Hanahan, D., & Baekkeskov, S. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9037 · Cited by 515
Nelson, C., Albert, V. R., Elsholtz, H. P., Lu, L. I.-W., & Rosenfeld, M. G. (1988) · Science · doi:10.1126/science.2831625 · Cited by 513
Structure of cloned DNA complementary to rat prolactin messenger RNA.
Cooke, N. E., Coit, D., Weiner, R. I., Baxter, J. D., & Martial, J. A. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43768-4 · Cited by 262
Self-citation
Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Molina, C. A., Foulkes, N. S., Lalli, E., & Sassone-Corsi, P. (1993) · Cell · doi:10.1016/0092-8674(93)90532-u · Cited by 600
Ito, M., Yu, R., & Jameson, J. L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1476 · Cited by 462
Wikenheiser, K. A., Vorbroker, D. K., Rice, W. R., Clark, J. C., Bachurski, C. J., Oie, H. K., & Whitsett, J. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11029 · Cited by 358
GnRH Pulsatility, the Pituitary Response and Reproductive Dysfunction
TSUTSUMI, R., & WEBSTER, N. J. G. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-185 · Cited by 317
Metadata
- Authors
- Windle, J. J., Weiner, R. I., & Mellon, P. L.
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1990-04
- Volume
- 4
- Issue
- 4
- Pages
- 597-603
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- OpenAlex
- W2116931151
- Cited by
- 493
- References
- 18
- FWCI
- 20.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Cell Lines of the Pituitary Gonadotrope Lineage Derived by Targeted Oncogenesis in Transgenic Mice. https://app.cochat.ai/papers/10.1210/mend-4-4-597
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- Windle, J. J., Weiner, R. I., & Mellon, P. L. (1990). Cell Lines of the Pituitary Gonadotrope Lineage Derived by Targeted Oncogenesis in Transgenic Mice. Molecular Endocrinology. https://doi.org/10.1210/mend-4-4-597
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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