The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice.
Open accessAbstract
We have explored the use of adenovirus-mediated gene transfer to transiently elicit production of low density lipoprotein (LDL) receptors in mice. A recombinant adenovirus carrying the human LDL receptor cDNA restored LDL receptor function in receptor-deficient cultured cells. Intravenous injection of recombinant virus acutely lowered plasma cholesterol levels and increased the rate of 125I-labeled LDL clearance from the circulation in normal mice. At 4 days after virus injection, the t1/2 of plasma LDL was reduced up to 10-fold. An estimated 90% of the parenchymal cells in liver expressed the adenovirus-transferred genes as judged by immunofluorescence of LDL receptors or by beta-galactosidase staining. These results demonstrate that adenovirus-mediated transfer of the LDL receptor gene provides an efficient way of augmenting LDL receptor gene function in the liver over the short term.
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Cites
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
Kowal, R. C., Herz, J., Weisgraber, K. H., Mahley, R. W., Brown, M. S., & Goldstein, J. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)87014-4 · Cited by 445
Self-citationBeisiegel, U., Schneider, W. J., Goldstein, J. L., Anderson, R. G., & Brown, M. S. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68494-2 · Cited by 357
Hofmann, S. L., Russell, D. W., Brown, M. S., Goldstein, J. L., & Hammer, R. E. (1988) · Science · doi:10.1126/science.3344433 · Cited by 117
Cited by
Ishibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E., & Herz, J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116663 · Cited by 1,354
Self-citationSOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
Rui, L., Yuan, M., Frantz, D., Shoelson, S., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200444200 · Cited by 904
Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
Kozarsky, K. F., Donahee, M. H., Rigotti, A., Iqbal, S. N., Edelman, E. R., & Krieger, M. (1997) · Nature · doi:10.1038/387414a0 · Cited by 699
Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate
Venkataraman, K., Lee, Y.-M., Michaud, J., Thangada, S., Ai, Y., Bonkovsky, H. L., Parikh, N. S., Habrukowich, C., & Hla, T. (2008) · Circulation Research · doi:10.1161/circresaha.107.165845 · Cited by 482
Engelhardt, J. F., Ye, X., Doranz, B., & Wilson, J. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.6196 · Cited by 470
Metadata
- Authors
- Herz, J., & Gerard, R. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-04
- Volume
- 90
- Issue
- 7
- Pages
- 2812-2816
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2082032640
- Cited by
- 517
- References
- 4
- FWCI
- 23.87
- Type
- journal article
- Language
- en
- Open access
- green
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