The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.
Open accessAbstract
Mutations in the gene for Cu/Zn superoxide dismutase (SOD1) have been detected in some families with an autosomal dominant form of amyotrophic lateral sclerosis; these mutations appear to reduce the activity of this enzyme. To determine whether decreased SOD activity could contribute to motor neuron loss, SOD1 was inhibited chronically with either antisense oligodeoxynucleotides or diethyldithiocarbamate in spinal cord organotypic cultures. Chronic inhibition of SOD resulted in the apoptotic degeneration of spinal neurons, including motor neurons, over several weeks. Motor neuron loss was markedly potentiated by the inhibition of glutamate transport. In this paradigm, motor neuron toxicity could be entirely prevented by the antioxidant N-acetylcysteine and, to a lesser extent, by the non-N-methyl-D-aspartate glutamate receptor antagonist 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride. These data support the hypothesis that the loss of motor neurons in familial amyotrophic lateral sclerosis could be due to a reduction in SOD1 activity, possibly potentiated by inefficient glutamate transport.
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Cites
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Self-citationBcl-2 functions in an antioxidant pathway to prevent apoptosis
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Amyotrophic Lateral Ssclerosis and Structural Defects in Cu,Zn Superoxide Dismutase
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Cited by
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
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Aging, energy, and oxidative stress in neurodegenerative diseases
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Oxidants as Stimulators of Signal Transduction
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Metadata
- Authors
- Rothstein, J. D., Bristol, L. A., Hosler, B., Brown, R. H., & Kuncl, R. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-05-10
- Volume
- 91
- Issue
- 10
- Pages
- 4155-4159
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1983913371
- Cited by
- 292
- References
- 33
- FWCI
- 26.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Rothstein, J. D., Bristol, L. A., Hosler, B., Brown, R. H., & Kuncl, R. W. (1994). Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.10.4155
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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