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Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease.
Open accessAbstract
Type IX collagen is a nonfibrillar collagen composed of three gene products, alpha 1(IX), alpha 2(IX), and alpha 3(IX). Type IX molecules are localized on the surface of type II-containing fibrils and consist of two arms, a long arm that is crosslinked to type II collagen and a short arm that projects into the perifibrillar space. In hyaline cartilage, the alpha 1(IX) collagen transcript encodes a polypeptide with a large N-terminal globular domain (NC4), whereas in many other tissues an alternative transcript encodes an alpha 1(IX) chain with a truncated NC4 domain. It has been proposed that type IX molecules are involved in the interaction of fibrils with each other or with other components of the extracellular matrix. To test this hypothesis, we have generated a mouse strain lacking both isoforms of the alpha 1(IX) chain. Homozygous mutant mice are viable and show no detectable abnormalities at birth but develop a severe degenerative joint disease resembling human osteoarthritis.
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Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
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Extracellular matrix structure
Theocharis, A. D., Skandalis, S. S., Gialeli, C., & Karamanos, N. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.001 · Cited by 2,598
Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading
KJÆR, M. (2004) · Physiological Reviews · doi:10.1152/physrev.00031.2003 · Cited by 1,586
The extracellular matrix in development and morphogenesis: A dynamic view
Rozario, T., & DeSimone, D. W. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.026 · Cited by 1,451
Engineering biocompatible implant surfaces
Bauer, S., Schmuki, P., von der Mark, K., & Park, J. (2013) · Progress in Materials Science · doi:10.1016/j.pmatsci.2012.09.001 · Cited by 780
Consequences of lack of beta 1 integrin gene expression in mice.
Fässler, R., & Meyer, M. (1995) · Genes & Development · doi:10.1101/gad.9.15.1896 · Cited by 729
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Metadata
- Authors
- Fässler, R., Schnegelsberg, P. N., Dausman, J., Shinya, T., Muragaki, Y., McCarthy, M. T., Olsen, B. R., & Jaenisch, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-05-24
- Volume
- 91
- Issue
- 11
- Pages
- 5070-5074
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1967160569
- Cited by
- 301
- References
- 1
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Fässler, R., Schnegelsberg, P. N., Dausman, J., Shinya, T., Muragaki, Y., McCarthy, M. T., Olsen, B. R., & Jaenisch, R. (1994). Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.11.5070
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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