Central effects of baroreceptor activation in humans: attenuation of skeletal reflexes and pain perception.
Open accessAbstract
Activating the arterial baroreceptors blunts pain sensation and produces other forms of central nervous system inhibition in animals. These effects may be important to blood pressure regulation but have not been rigorously verified in humans. We describe (i) a noninvasive behaviorally unbiased method for baroreceptor stimulation and (ii) the application of this method to measurement of baroreceptor-mediated attenuation of pain perception and of the Achilles tendon reflex. The findings are relevant to basic mechanisms of blood pressure stabilization and cardiovascular reactivity and may also have implications for noncompliance with antihypertensive medications and for the pathophysiology of essential hypertension.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In humans, artificially boosting baroreceptor activation reduces pain sensation.
“In humans, artificially boosting baroreceptor activation reduces pain sensation 53 .”
From Interoceptive rhythms in the brain (2023) · cites this paper as [53]
The paper’s title identifies attenuation of pain perception as an effect of baroreceptor activation in humans. The available non-abstract passages do not describe the intervention, so they do not establish that the activation was artificially boosted. (LLM, conf=0.68)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
Basbaum, A. I., & Fields, H. L. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001521 · Cited by 2,687 · see citing works
Blood Pressure During Normal Daily Activities, Sleep, and Exercise
Pickering, T. G. (1982) · JAMA · doi:10.1001/jama.247.7.992 · Cited by 522 · see citing works
Human Baroreflexes in Health and Disease
Eckberg, D. L., & Sleight, P. (1992) · doi:10.1093/oso/9780198576938.001.0001 · Cited by 502 · see citing works
Tonus sympathique et activité électrique corticale
Bonvallet, M., Dell, P., & Hiebel, G. (1954) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(54)90011-5 · Cited by 418 · see citing works
Interactions between cardiovascular and pain regulatory systems
Randich, A., & Maixner, W. D. (1984) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(84)90057-5 · Cited by 409 · see citing works
Barraco, I. R. A. (2019) · CRC Press eBooks · doi:10.1201/9780429277214 · Cited by 365 · see citing works
Baroreceptor activation reduces reactivity to noxious stimulation: implications for hypertension.
Dworkin, B., Filewich, R. J., Miller, N., Craigmyle, N., & Pickering, T. (1979) · Science · doi:10.1126/science.472749 · Cited by 319 · see citing works
Self-citationA simplified neck suction device for activation of carotid baroreceptors.
Eckberg, D. L., Cavanaugh, M. S., Mark, A. L., & Abboud, F. M. (1975) · PubMed · Cited by 291 · see citing works
The intracutaneous stimulus: a new pain model for algesimetric studies.
Bromm, B., & Meier, W. (1984) · PubMed · Cited by 220 · see citing works
Temporal response patterns of the human sinus node to brief carotid baroreceptor stimuli.
Eckberg, D. L. (1976) · The Journal of Physiology · doi:10.1113/jphysiol.1976.sp011445 · Cited by 165 · see citing works
PROLONGED EXPOSURE TO A STRESSFUL STIMULUS (NOISE) AS A CAUSE OF RAISED BLOOD-PRESSURE IN MAN
Jönsson, A., & Hansson, L. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91093-5 · Cited by 165 · see citing works
The influence of happiness, anger, and anxiety on the blood pressure of borderline hypertensives.
James, G. D., Yee, L. S., Harshfield, G. A., Blank, S. G., & Pickering, T. G. (1986) · Psychosomatic Medicine · doi:10.1097/00006842-198609000-00005 · Cited by 160 · see citing works
Noise Raises Blood Pressure Without Impairing Auditory Sensitivity
Peterson, E. A., Augenstein, J. S., Tanis, D. C., & Augenstein, D. G. (1981) · Science · doi:10.1126/science.7466404 · Cited by 126 · see citing works
CARDIAC DECELERATION AND REACTION TIME: AN EVALUATION OF TWO HYPOTHESES
Obrist, P. A., Webb, R. A., Sutterer, J. R., & Howard, J. L. (1970) · Psychophysiology · doi:10.1111/j.1469-8986.1970.tb02257.x · Cited by 120 · see citing works
Situational Variations of Blood Pressure in Ambulatory Hypertensive Patients
Harshfield, G. A., Pickering, T. G., Kleinert, H. D., Blank, S. G., & Laragh, J. H. (1982) · Psychosomatic Medicine · doi:10.1097/00006842-198207000-00002 · Cited by 102 · see citing works
Callaway, E., & Layne, R. S. (1964) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1964.tb26762.x · Cited by 101 · see citing works
Lingual Vein Injection in the Rat
Anderson, J. M. (1963) · Science · doi:10.1126/science.140.3563.195-a · Cited by 94 · see citing works
PRES: The Controlled Noninvasiv Stimulation of the Carotid Baroreceptors in Humans
Rau, H., Elbert, T. R., Geiger, B., & Lutzenberger, W. (1992) · Psychophysiology · doi:10.1111/j.1469-8986.1992.tb01680.x · Cited by 51 · see citing works
Self-citationModulation of Slow Cortical Potentials by Instrumentally Learned Blood Pressure Responses
Elbert, T. R., Roberts, L. E., Lutzenberger, W., & Birbaumer, N. (1992) · Psychophysiology · doi:10.1111/j.1469-8986.1992.tb01678.x · Cited by 42 · see citing works
Self-citationMeyer-Sabellek, W., Gotzen, R., Anlauf, M., & Steinfeld, L. (1990) · Steinkopff eBooks · doi:10.1007/978-3-642-72423-7 · Cited by 37 · see citing works
Furedy, J. J., Rau, H., & Roberts, L. E. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90376-d · Cited by 19 · see citing works
Self-citationInternational Perspectives on Self-Regulation and Health
(1991) · Springer eBooks · doi:10.1007/978-1-4899-2596-1 · Cited by 18 · see citing works
Garsik, J. T., Low, W. C., & Whitehorn, D. (1983) · Brain Research · doi:10.1016/0006-8993(83)91384-7 · Cited by 12 · see citing works
Interoception and Behavior—An Experimental Study
Talland, G. A. (1968) · Psychosomatic Medicine · doi:10.1097/00006842-196805000-00016 · Cited by 11 · see citing works
Rau, H., Brody, S., Droste, C., & Kardos, A. (1993) · European Journal of Applied Physiology · doi:10.1007/bf00377699 · Cited by 10 · see citing works
Self-citation[The carotid sinus and cerebral electrical activity].
Bonvallet, M., Dell, P. C., & Hiebel, G. (1953) · PubMed · Cited by 8 · see citing works
Adám, G., BELA, A., Koo, E., & Székely, J. I. (1963) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- BONVALLET M., DELL P., HIEBEL G. Sinus carotidien et activité électrique cérébrale. C R Seances Soc Biol Fil. 1953 Jul;147(13-14):1166–1169. [PubMed] [Google Scholar]
Cited by
Sorted by citations
Kosek, E., & Hansson, P. T. (1997) · Pain · doi:10.1016/s0304-3959(96)03295-2 · Cited by 539 · see citing works
Kosek, E., & Ordeberg, G. (2000) · Pain · doi:10.1016/s0304-3959(00)00310-9 · Cited by 476 · see citing works
Visceral Signals Shape Brain Dynamics and Cognition
Azzalini, D., Rebollo, I., & Tallon-Baudry, C. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2019.03.007 · Cited by 409 · see citing works
Bruehl, S. P., & Chung, O. Y. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.06.004 · Cited by 377 · see citing works
Gianaros, P. J., van der Veen, F. M., & Jennings, J. R. (2004) · Psychophysiology · doi:10.1111/1469-8986.2004.00179.x · Cited by 327 · see citing works
Hypertension-Associated Hypalgesia
Ghione, S. (1996) · Hypertension · doi:10.1161/01.hyp.28.3.494 · Cited by 320 · see citing works
Shi, Y., Weingarten, T. N., Mantilla, C. B., Hooten, W. M., & Warner, D. O. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181ebdaf9 · Cited by 304 · see citing works
Threat and the body: how the heart supports fear processing
Garfinkel, S. N., & Critchley, H. D. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.005 · Cited by 298 · see citing works
Nijs, J. (2012) · Pain Physician · doi:10.36076/ppj.2012/15/es205 · Cited by 307 · see citing works
Towards a comprehensive assessment of interoception in a multi-dimensional framework
Suksasilp, C., & Garfinkel, S. N. (2022) · Biological Psychology · doi:10.1016/j.biopsycho.2022.108262 · Cited by 288 · see citing works
Similarities between exercise-induced hypoalgesia and conditioned pain modulation in humans
Vægter, H. B., Handberg, G., & Graven‐Nielsen, T. (2013) · Pain · doi:10.1016/j.pain.2013.09.023 · Cited by 253 · see citing works
Relationships between features of autonomic cardiovascular control and cognitive performance
Duschek, S., Muckenthaler, M., Werner, N., & Reyes del Paso, G. A. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.03.003 · Cited by 249 · see citing works
Jansen, A. S. P., Wessendorf, M. W., & Loewy, A. D. (1995) · Brain Research · doi:10.1016/0006-8993(95)00276-v · Cited by 229 · see citing works
Elevated blood pressure and personality: A meta-analytic review.
Jorgensen, R. S., Johnson, B. T., Kolodziej, M. E., & Schreer, G. E. (1996) · Psychological Bulletin · doi:10.1037/0033-2909.120.2.293 · Cited by 229 · see citing works
Interoceptive rhythms in the brain
Engelen, T., Solcà, M., & Tallon-Baudry, C. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01425-1 · Cited by 207 · see citing works
Race and Sex Differences in Cutaneous Pain Perception
Sheffield, D., Biles, P. L., Orom, H., Maixner, W. D., & Sheps, D. S. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200007000-00010 · Cited by 218 · see citing works
Pain and respiration: a systematic review
Jafari, H., Courtois, I., den Bergh, O. V., Vlaeyen, J. W. S., & Diest, I. V. (2017) · Pain · doi:10.1097/j.pain.0000000000000865 · Cited by 203 · see citing works
Bragdon, E. E., Light, K. C., Costello, N. L., Sigurðsson, Á., Bunting, S., Bhalang, K., & Maixner, W. D. (2002) · Pain · doi:10.1016/s0304-3959(01)00451-1 · Cited by 196 · see citing works
Daenen, L., Varkey, E., Kellmann, M., & Nijs, J. (2014) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000099 · Cited by 190 · see citing works
Ascending visceral regulation of cortical affective information processing
Berntson, G. G., Sarter, M. F., & Cacioppo, J. T. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02967.x · Cited by 185 · see citing works
The Influence of Resting Blood Pressure and Gender on Pain Responses
Fillingim, R. B., & Maixner, W. D. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199607000-00005 · Cited by 180 · see citing works
Psychophysiology of arterial baroreceptors and the etiology of hypertension
Rau, H., & Elbert, T. R. (2001) · Biological Psychology · doi:10.1016/s0301-0511(01)00094-1 · Cited by 177 · see citing works
Self-citationEmotional appraisal is influenced by cardiac afferent information
Gray, M. A., Beacher, F. D., Minati, L., Nagai, Y., Kemp, A. H., Harrison, N. A., & Critchley, H. D. (2012) · Emotion · doi:10.1037/a0025083 · Cited by 163 · see citing works
Maixner, W. D., Fillingim, R. B., Kincaid, S., Sigurðsson, Á., & Harris, M. B. (1997) · Psychosomatic Medicine · doi:10.1097/00006842-199709000-00007 · Cited by 163 · see citing works
Bruehl, S. P., Chung, O. Y., Ward, P., Johnson, B. W., & McCubbin, J. A. (2002) · Pain · doi:10.1016/s0304-3959(02)00295-6 · Cited by 163 · see citing works
Bruehl, S. P., Chung, O. Y., Jirjis, J. N., & Biridepalli, S. (2005) · Clinical Journal of Pain · doi:10.1097/00002508-200503000-00006 · Cited by 159 · see citing works
Following One's Heart: Cardiac Rhythms Gate Central Initiation of Sympathetic Reflexes
Gray, M. A., Rylander, K., Harrison, N. A., Wallin, B. G., & Critchley, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3363-08.2009 · Cited by 156 · see citing works
Nijs, J., Kosek, E., Oosterwijck, J. V., & Meeus, M. (2012) · PubMed · Cited by 129 · see citing works
Tozman, T., Magdas, E. S., MacDougall, H. G., & Vollmeyer, R. (2015) · Computers in Human Behavior · doi:10.1016/j.chb.2015.06.023 · Cited by 128 · see citing works
The functional role of cardiac activity in perception and action
Skora, L. I., Livermore, J. J. A., & Roelofs, K. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104655 · Cited by 125 · see citing works
Leffler, A., Hansson, P. T., & Kosek, E. (2002) · European Journal of Pain · doi:10.1053/eujp.2001.0312 · Cited by 120 · see citing works
Stress and Psychophysiological Dysregulation in Patients with Fibromyalgia Syndrome
Okifuji, A., & Turk, D. C. (2002) · Applied Psychophysiology and Biofeedback · doi:10.1023/a:1016243710507 · Cited by 116 · see citing works
TMD and chronic pain: A current view
Furquim, B. D., Fiamengui, L. M. S. P., & Conti, P. C. R. (2015) · Dental Press Journal of Orthodontics · doi:10.1590/2176-9451.20.1.127-133.sar · Cited by 115 · see citing works
Exercise, Hypoalgesia and Blood Pressure
Koltyn, K. F., & Umeda, M. (2006) · Sports Medicine · doi:10.2165/00007256-200636030-00003 · Cited by 114 · see citing works
Fingleton, C., Smart, K. M., & Doody, C. (2016) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000418 · Cited by 111 · see citing works
Theoretical review: altered pain regulatory systems in chronic pain
Bruehl, S. P., McCubbin, J. A., & Harden, R. N. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00039-1 · Cited by 111 · see citing works
Associations between mental health, blood pressure and the development of hypertension
Schaare, H. L., Blöchl, M., Kumral, D., Uhlig, M., Lemcke, L., Valk, S. L., & Villringer, A. (2023) · Nature Communications · doi:10.1038/s41467-023-37579-6 · Cited by 118 · see citing works
The behavioral impact of baroreflex function: A review
Duschek, S., Werner, N. S., & del Paso, G. A. R. (2013) · Psychophysiology · doi:10.1111/psyp.12136 · Cited by 102 · see citing works
Role of Abnormal Pain Sensitivity and Behavioral Factors in Determining Chest Pain in Syndrome X
Pasceri, V., Lanza, G. A., Buffon, A., MONTENERO, A. S., Crea, F., & Maseri, A. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00421-x · Cited by 104 · see citing works
Brain correlates of stress-induced analgesia
Yilmaz, P., Diers, M., Diener, S. J., Rance, M., Wessa, M., & Flor, H. (2010) · Pain · doi:10.1016/j.pain.2010.08.016 · Cited by 99 · see citing works
Badrov, M. B., Horton, S., Millar, P., & McGowan, C. (2013) · Psychophysiology · doi:10.1111/psyp.12031 · Cited by 93 · see citing works
Radaelli, A., Raco, R., Perfetti, P., Viola, A., Azzellino, A., Signorini, M. G., & Ferrari, A. U. (2004) · Journal of Hypertension · doi:10.1097/01.hjh.0000125446.28861.51 · Cited by 88 · see citing works
Interactions between visceral afferent signaling and stimulus processing
Critchley, H. D., & Garfinkel, S. N. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00286 · Cited by 89 · see citing works
Isometric exercises reduce temporal summation of pressure pain in humans
Vaegter, H. B., Handberg, G., & Graven‐Nielsen, T. (2015) · European Journal of Pain · doi:10.1002/ejp.623 · Cited by 91 · see citing works
Expression of Opioid Receptors During Heart Ontogeny in Normotensive and Hypertensive Rats
Zimlichman, R., Gefel, D., Eliahou, H. E., Matas, Z., Rosen, B. D., Gass, S., Ela, C., Eilam, Y., Vogel, Z., & Barg, J. (1996) · Circulation · doi:10.1161/01.cir.93.5.1020 · Cited by 85 · see citing works
Baroreceptor cortical effects, emotions and pain
Mini, A., Rau, H., Montoya, P., Palomba, D., & Birbaumer, N. (1995) · International Journal of Psychophysiology · doi:10.1016/0167-8760(94)00084-r · Cited by 80 · see citing works
Self-citationBidirectional interactions between the baroreceptor reflex and arousal: an update
Silvani, A., Buonaura, G. C., Benarroch, E. E., Dampney, R. A. L., & Cortelli, P. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.10.011 · Cited by 79 · see citing works
Cardiovascular influences on conditioned pain modulation
Chalaye, P., Devoize, L., Lafrenaye, S., Dallel, R., & Marchand, S. (2013) · Pain · doi:10.1016/j.pain.2013.04.027 · Cited by 78 · see citing works
Chronic Pain-Associated Cardiovascular Disease: The Role of Sympathetic Nerve Activity
Reynolds, C. A., & Minić, Ž. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065378 · Cited by 77 · see citing works
Chalaye, P., Goffaux, P., Bourgault, P., Lafrenaye, S., Devroede, G. J., Watier, A., & Marchand, S. (2012) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31823ae69e · Cited by 78 · see citing works
Daniali, H., & Flaten, M. A. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00242 · Cited by 76 · see citing works
Baroreceptor activation attenuates attentional effects on pain-evoked potentials
Gray, M. A., Minati, L., Paoletti, G., & Critchley, H. (2010) · Pain · doi:10.1016/j.pain.2010.09.028 · Cited by 74 · see citing works
Effects of artificial and natural baroreceptor stimulation on nociceptive responding and pain
Edwards, L., McIntyre, D. B., Carroll, D., Ring, C., France, C. R., & Martin, U. (2003) · Psychophysiology · doi:10.1111/1469-8986.00076 · Cited by 71 · see citing works
Aerobic Exercise and Cold Pressor Test Induce Hypoalgesia in Active and Inactive Men and Women
Vægter, H. B., Handberg, G., Jørgensen, M. N., Kinly, A., & Graven‐Nielsen, T. (2014) · Pain Medicine · doi:10.1111/pme.12641 · Cited by 71 · see citing works
Anger in brain and body: the neural and physiological perturbation of decision-making by emotion
Garfinkel, S. N., Zorab, E., Navaratnam, N., Engels, M., Mallorquí‐Bagué, N., Minati, L., Dowell, N. G., BROSSCHOT, J. F., Thayer, J. F., & Critchley, H. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv099 · Cited by 69 · see citing works
Can Slow Deep Breathing Reduce Pain? An Experimental Study Exploring Mechanisms
Jafari, H., Gholamrezaei, A., Franssen, M., Oudenhove, L. V., Aziz, Q., den Bergh, O. V., Vlaeyen, J. W. S., & Diest, I. V. (2020) · Journal of Pain · doi:10.1016/j.jpain.2019.12.010 · Cited by 66 · see citing works
Duschek, S., Mück, I., & del Paso, G. A. R. (2007) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2007.03.012 · Cited by 64 · see citing works
Resonances in the cardiovascular system caused by rhythmical muscle tension
Vaschillo, E. G., Vaschillo, B., Pandina, R. J., & Bates, M. E. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2010.01156.x · Cited by 63 · see citing works
Baroreceptor Modulation of the Cardiovascular System, Pain, Consciousness, and Cognition
Suárez-Roca, H., Mamoun, N. F., Sigurdsson, M. I., & Maixner, W. D. (2021) · Comprehensive physiology · doi:10.1002/cphy.c190038 · Cited by 95 · see citing works
Peripheral Mechanisms of Ischemic Myalgia
Queme, L. F., Ross, J. L., & Jankowski, M. P. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00419 · Cited by 57 · see citing works
Hypertension-related hypoalgesia, autonomic function and spontaneous baroreflex sensitivity
Guasti, L., Zanotta, D., Mainardi, L. T., Petrozzino, M. R., Grimoldi, P., Garganico, D., Diolisi, A., Gaudio, G. V., Klersy, C., Grandi, A. M., et al. (2002) · Autonomic Neuroscience · doi:10.1016/s1566-0702(02)00052-8 · Cited by 60 · see citing works
Reduced baroreflex cardiac sensitivity predicts increased cognitive performance
Yasumasu, T., del Paso, G. A. R., Takahara, K., & Nakashima, Y. (2006) · Psychophysiology · doi:10.1111/j.1469-8986.2006.00377.x · Cited by 59 · see citing works
Strohman, A., Payne, B., In, A., Stebbins, K., & Legon, W. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1011-23.2023 · Cited by 55 · see citing works
Tuveson, B., Leffler, A., & Hansson, P. T. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2005.03.010 · Cited by 55 · see citing works
The Influence of Low Blood Pressure and Baroreceptor Activity on Pain Responses
Angrilli, A., Mini, A., Mucha, R. F., & Rau, H. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00039-5 · Cited by 55 · see citing works
Self-citationBragdon, E. E., Light, K. C., Girdler, S. S., & Maixner, W. D. (1997) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0401_2 · Cited by 55 · see citing works
del Paso, G. A. R., Montoro, C. I., de Guevara, C. M. L., Duschek, S., & Jennings, J. R. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.07.004 · Cited by 54 · see citing works
del Paso, G. A. R., González, I., & Hernández, J. A. (2004) · Biological Psychology · doi:10.1016/j.biopsycho.2004.02.001 · Cited by 54 · see citing works
Blood pressure but not parental history for hypertension predicts pain perception in women
Al’Absi, M., Petersen, K. L., & Wittmers, L. E. (2000) · Pain · doi:10.1016/s0304-3959(00)00306-7 · Cited by 54 · see citing works
Treatment With Enalapril Modifies the Pain Perception Pattern in Hypertensive Patients
Guasti, L., Grimoldi, P., Diolisi, A., Petrozzino, M. R., Gaudio, G., Grandi, A. M., Rossi, M. G., & Venco, A. (1998) · Hypertension · doi:10.1161/01.hyp.31.5.1146 · Cited by 54 · see citing works
Sweet taste and blood pressure-related analgesia
Lewkowski, M. D., Ditto, B., Roussos, M., & Young, S. N. (2003) · Pain · doi:10.1016/s0304-3959(03)00333-6 · Cited by 53 · see citing works
Covariation bias in panic-prone individuals.
Pauli, P., Montoya, P., & Martz, G.-E. (1996) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.105.4.658 · Cited by 53 · see citing works
Self-citationHeart Rate Variability, Homeostasis, and Brain Function
Riganello, F., Garbarino, S., & Sannita, W. G. (2012) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000080 · Cited by 52 · see citing works
Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes
Suárez-Roca, H., Klinger, R. Y., Podgoreanu, M. V., Ji, R., Sigurdsson, M. I., Waldron, N. H., Mathew, J. P., & Maixner, W. D. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002510 · Cited by 51 · see citing works
Interoceptive cardiac signals selectively enhance fear memories.
Garfinkel, S. N., van Praag, C. G., Engels, M., Watson, D. R., Silva, M., Evans, S., Duka, T., & Critchley, H. (2020) · Journal of Experimental Psychology General · doi:10.1037/xge0000967 · Cited by 51 · see citing works
Brody, S., Angrilli, A., Weiss, U., Birbaumer, N., Mini, A., Veit, R., & Rau, H. (1997) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(96)00740-4 · Cited by 50 · see citing works
Self-citationGuasti, L., Gaudio, G. V., Zanotta, D., Grimoldi, P., Petrozzino, M. R., Tanzi, F., Bertolini, A., Grandi, A. M., & Venco, A. (1999) · Pain · doi:10.1016/s0304-3959(99)00059-7 · Cited by 49 · see citing works
Cardiac cycle time effects on mask inhibition
Pramme, L., Larra, M. F., Schächinger, H., & Frings, C. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.05.008 · Cited by 48 · see citing works
Association of Elevated Blood Pressure With Low Distress and Good Quality of Life
Berendes, A., Meyer, T., Hulpke‐Wette, M., & Herrmann‐Lingen, C. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31828ef0c2 · Cited by 48 · see citing works
Elbert, T. R., Dworkin, B. R., Rau, H., Pauli, P., Birbaumer, N., Droste, C., & BRUNIA, C. H. M. (1994) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0103_3 · Cited by 48 · see citing works
Self-citationCardiopulmonary baroreflex stimulation and blood pressure-related hypoalgesia
D’Antono, B., Ditto, B., Sita, A., & Miller, S. B. (2000) · Biological Psychology · doi:10.1016/s0301-0511(00)00044-2 · Cited by 47 · see citing works
McCubbin, J. A., Loveless, J. P., Graham, J. G., Hall, G. A., Bart, R. M., Moore, D. D., Merritt, M. M., Lane, R. D., & Thayer, J. F. (2013) · Annals of Behavioral Medicine · doi:10.1007/s12160-013-9526-2 · Cited by 46 · see citing works
Grande‐Alonso, M., Suso‐Martí, L., Cuenca‐Martínez, F., Pardo-Montero, J., Gil‐Martínez, A., & Touche, R. L. (2019) · Pain Medicine · doi:10.1093/pm/pnz093 · Cited by 44 · see citing works
Muscle pain perception and sympathetic nerve activity to exercise during opioid modulation
Cook, D. B., O’Connor, P. J., & Ray, C. A. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.5.r1565 · Cited by 44 · see citing works
Inhibition of human muscle sympathetic activity by sensory stimulation
Donadio, V. A., Kallio, M., Karlsson, T., Nordin, M., & Wallin, B. G. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.019596 · Cited by 44 · see citing works
Supine posture inhibits cortical activity: Evidence from Delta and Alpha EEG bands
Spironelli, C., Busenello, J., & Angrilli, A. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.06.015 · Cited by 43 · see citing works
del Paso, G. A. R., González, M. I., Hernández, J. A., Duschek, S., & Palma, N. G. (2009) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00832.x · Cited by 43 · see citing works
Susceptibility to Pain in Hypertensive and Normotensive Patients With Coronary Artery Disease
Falcone, C., Auguadro, C., Sconocchia, R., & ANGOLI, L. (1997) · Hypertension · doi:10.1161/01.hyp.30.5.1279 · Cited by 43 · see citing works
The Effects of Pain and Analgesic Medications on Blood Pressure
Rivasi, G., Menale, S., Turrin, G., Coscarelli, A., Giordano, A., & Ungar, A. (2022) · Current Hypertension Reports · doi:10.1007/s11906-022-01205-5 · Cited by 44 · see citing works
Tuveson, B., Leffler, A., & Hansson, P. T. (2009) · Pain · doi:10.1016/j.pain.2009.02.002 · Cited by 42 · see citing works
Risk for hypertension and diminished pain sensitivity in women: autonomic and daily correlates
D’Antono, B., Ditto, B., Rios, N., & Moskowitz, D. S. (1999) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(98)00057-9 · Cited by 42 · see citing works
Interactions between autonomic cardiovascular regulation and cortical activity: A CNV study
Duschek, S., Wörsching, J., & del Paso, G. A. R. (2013) · Psychophysiology · doi:10.1111/psyp.12026 · Cited by 40 · see citing works
Buckman, J. F., Vaschillo, B., Vaschillo, E. G., Epstein, E. E., Nguyen‐Louie, T. T., Lesnewich, L. M., Eddie, D., & Bates, M. E. (2019) · Psychology of Addictive Behaviors · doi:10.1037/adb0000524 · Cited by 39 · see citing works
Baroreceptor Modulation of the Cardiovascular System, Pain, Consciousness, and Cognition
Suárez-Roca, H., Mamoun, N. F., Sigurdsson, M. I., & Maixner, W. D. (2021) · Comprehensive physiology · doi:10.1002/j.2040-4603.2021.tb00152.x · Cited by 39 · see citing works
Delgado, L. C., Vila, J., & del Paso, G. A. R. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.11.005 · Cited by 39 · see citing works
Effects of baroreceptor stimulation and opioids on the auditory startle reflex
Nyklíček, I., Wijnen, V. J. M., & Rau, H. (2005) · Psychophysiology · doi:10.1111/j.1469-8986.2005.00273.x · Cited by 39 · see citing works
Self-citationApplying the Theory of Constructed Emotion to Police Decision Making
Fridman, J., Barrett, L. F., Wormwood, J. B., & Quigley, K. S. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01946 · Cited by 37 · see citing works
Enhanced pain perception prior to smoking cessation is associated with early relapse
Nakajima, M., & Al’Absi, M. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.07.006 · Cited by 36 · see citing works
Significance of neuro-cardiac control mechanisms governed by higher regions of the brain
Taggart, P. I., Critchley, H., van Duijvendoden, S., & Lambiase, P. D. (2016) · Autonomic Neuroscience · doi:10.1016/j.autneu.2016.08.013 · Cited by 36 · see citing works
The impact of cardiac phases on multisensory integration
Saltafossi, M., Zaccaro, A., Perrucci, M. G., Ferri, F., & Costantini, M. (2023) · Biological Psychology · doi:10.1016/j.biopsycho.2023.108642 · Cited by 40 · see citing works
- Authors
- Dworkin, B. R., Elbert, T., Rau, H., Birbaumer, N., Pauli, P., Droste, C., & Brunia, C. H.
- Affiliations
- Pennsylvania State University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1994-07-05
- Volume
- 91
- Issue
- 14
- Pages
- 6329-6333
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC44195
- OpenAlex
- W2119445707
- Cited by
- 251
- References
- 27
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 12 · 2023: 12 · 2022: 11 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 15 · 2012: 8
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research portal (Tilburg University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- KOPS (University of Konstanz) (submittedVersion, cc-by-nc-nd)
- Funders
- National Heart, Lung, and Blood Institute (R01 HL40837, R01HL040837)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- baroreceptor activation, pain perception, Achilles tendon reflex, central nervous system inhibition, blood pressure regulation, cardiovascular reactivity, essential hypertension
- MeSH terms
- Achilles Tendon, Adult, Analysis of Variance, Blood Pressure, Carotid Arteries, Central Nervous System, Electric Stimulation, Humans, Hypertension, Middle Aged, Muscle, Smooth, Vascular, Pain, Pressoreceptors, Reflex, Sensory Thresholds, Myocardial Ischemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
