The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I.
Open accessAbstract
Grb2 is a 25-kDa adaptor protein composed of a Src homology 2 (SH2) domain and two flanking Src homology 3 (SH3) domains. One function of Grb2 is to couple tyrosine-phosphorylated proteins (through its SH2 domain) to downstream effectors (through its SH3 domains). Using an overlay assay, we have identified four major Grb2-binding proteins in synaptic fractions. These proteins interact with wild-type Grb2 but not with Grb2 containing point mutations in each of its two SH3 domains corresponding to the loss of function mutants in the Caenorhabditis elegans Grb2 homologue sem-5. Two of the proteins, mSos and dynamin, were previously shown to bind Grb2. The third protein of 145 kDa is brain specific and to our knowledge has not been previously described. The fourth protein is synapsin I. Dynamin is required for synaptic vesicle endocytosis and synapsin I is thought to mediate the interaction of synaptic vesicles with the presynaptic cytomatrix. These data suggest that Grb2, or other proteins containing SH3 domains, may play a role in the regulation of the exo/endocytotic cycle of synaptic vesicles and therefore of neurotransmitter release.
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Cites
Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins
Bar-Sagi, D., & Feramisco, J. R. (1986) · Science · doi:10.1126/science.3090687 · Cited by 734
Cited by
ENDOCYTOSIS AND MOLECULAR SORTING
Mellman, I. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.575 · Cited by 1,533
Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals
Takei, K., McPherson, P. S., Schmid, S. L., & Camilli, P. D. (1995) · Nature · doi:10.1038/374186a0 · Cited by 767
Self-citationThe synapsins: Key actors of synapse function and plasticity
Cesca, F., Baldelli, P., Valtorta, F., & Benfenati, F. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.006 · Cited by 654
Self-citationA presynaptic inositol-5-phosphatase
McPherson, P. S., Garcia, E. P., Slepnev, V. I., David, C., Zhang, X., Grabs, D., Sossini, W. S., Bauerfeind, R., Nemoto, Y., & De Camilli, P. (1996) · Nature · doi:10.1038/379353a0 · Cited by 584
Self-citationDi Paolo, G., Pellegrini, L., Letinic, K., Cestra, G., Zoncu, R., Voronov, S., Chang, S., Guo, J., Wenk, M. R., & De Camilli, P. (2002) · Nature · doi:10.1038/nature01147 · Cited by 441
Metadata
- Authors
- McPherson, P. S., Czernik, A. J., Chilcote, T. J., Onofri, F., Benfenati, F., Greengard, P., Schlessinger, J., & De Camilli, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-07-05
- Volume
- 91
- Issue
- 14
- Pages
- 6486-6490
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2055455533
- Cited by
- 159
- References
- 1
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- green
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- McPherson, P. S., Czernik, A. J., Chilcote, T. J., Onofri, F., Benfenati, F., Greengard, P., Schlessinger, J., & De Camilli, P. (1994). Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.14.6486
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