The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo.
Open accessAbstract
Recent in vitro results suggest that the heterogeneous nuclear ribonucleoparticle (hnRNP) A1 protein modulates alternative splicing by favoring distal 5' splice site (5'SS) selection and exon skipping. We used a mouse erythroleukemia (MEL) cell line (CB3C7) deficient in the expression of hnRNP A1 to test whether variations in hnRNP A1 and AlB protein levels affected alternative splicing in vivo. In contrast to A1-expressing MEL cell lines, CB3C7 cells preferentially selected the proximal 13S and 12S 5'SS on the adenovirus E1A pre-mRNA. Transiently expressing the A1 or A1B cDNA in CB3C7 cells shifted 5'SS selection toward the more distal 9S donor site. A1 protein synthesis was required for this effect since the expression of a mutated A1 cDNA did not affect 5'SS selection. These results demonstrate that in vivo variations in hnRNP A1 protein levels can influence 5'SS selection.
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Ben-David, Y., Giddens, E. B., Letwin, K., & Bernstein, A. (1991) · Genes & Development · doi:10.1101/gad.5.6.908 · Cited by 403
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Cited by
The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a
Guil, S., & Cáceres, J. F. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1250 · Cited by 567
A nuclear localization domain in the hnRNP A1 protein.
Siomi, H., & Dreyfuss, G. (1995) · The Journal of cell biology · doi:10.1083/jcb.129.3.551 · Cited by 503
A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm
Cáceres, J. F., Screaton, G. R., & Krainer, A. R. (1998) · Genes & Development · doi:10.1101/gad.12.1.55 · Cited by 493
Cáceres, J. F., Misteli, T., Screaton, G. R., Spector, D. L., & Krainer, A. R. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.2.225 · Cited by 416
hnRNP Proteins and Splicing Control
Martinez-Contreras, R., Cloutier, P., Shkreta, L., Fisette, J.-F., Revil, T., & Chabot, B. (2007) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-387-77374-2_8 · Cited by 398
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Metadata
- Authors
- Yang, X., Bani, M. R., Lu, S. J., Rowan, S., Ben-David, Y., & Chabot, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-07-19
- Volume
- 91
- Issue
- 15
- Pages
- 6924-6928
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2096179259
- Cited by
- 191
- References
- 1
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, X., Bani, M. R., Lu, S. J., Rowan, S., Ben-David, Y., & Chabot, B. (1994). The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.15.6924
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