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FLT3-ITD cooperates with Rac1 to modulate the sensitivity of leukemic cells to chemotherapeutic agents via regulation of DNA repair pathways

Wu, M. H., Li, L., Hamaker, M. C., Small, D., & Duffield, A. S. (2019) · Haematologica · doi:10.3324/haematol.2018.208843 · Cited by 35

Mutant FLT3 signaling contributes to a block in myeloid differentiation

Zheng, R., & Small, D. (2005) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190500261740 · Cited by 35

Monitoring Antisense Oligodeoxynucleotide Activity in Hematopoietic Cells

Sokol, D. L., & Gewirtz, A. M. (1999) · Methods · doi:10.1006/meth.1998.0732 · Cited by 35

Novel FLT3 tyrosine kinase inhibitors

Levis, M. J., & Small, D. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.12.1951 · Cited by 35

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease

Rau, R. E., Magoon, D., Greenblatt, S. M., Li, L., Annesley, C., Duffield, A. S., Huso, D. L., McIntyre, E., Clohessy, J. G., Reschke, M., et al. (2013) · Experimental Hematology · doi:10.1016/j.exphem.2013.10.005 · Cited by 35

Retroviral transduction of human progenitor cells: use of granulocyte colony-stimulating factor plus stem cell factor to mobilize progenitor cells in vivo and stimulation by Flt3/Flk-2 ligand in vitro

Elwood, N. J., Zogos, H., Willson, T. A., & Begley, C. G. (1996) · Blood · doi:10.1182/blood.v88.12.4452.bloodjournal88124452 · Cited by 34

Bench to Bedside Targeting of FLT3 in Acute Leukemia

Pratz, K. W., & Levis, M. J. (2010) · Current Drug Targets · doi:10.2174/138945010791320782 · Cited by 33

Structure-Function Analysis of FLT3 Ligand-FLT3 Receptor Interactions Using a Rapid Functional Screen

Graddis, T. J., Brasel, K., Friend, D. J., Srinivasan, S., Wee, S., Lyman, S. D., March, C. J., & McGrew, J. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17626 · Cited by 33

FLT3/D835Y mutation knock-in mice display less aggressive disease compared with FLT3/internal tandem duplication (ITD) mice

Bailey, E., Li, L., Duffield, A. S., Ma, H. S., Huso, D. L., & Small, D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310559110 · Cited by 34

Differential Expression of Receptors for Hemopoietic Growth Factors on Subsets of CD34+Hemopoietic Cells

Wognum, A. W., Jong, M. O. D., & Wagemaker, G. (1996) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199609045710 · Cited by 34

Advances in hematopoietic stem cell culture

Audet, J., Zandstra, P. W., Eaves, C. J., & Piret, J. M. (1998) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(98)80107-9 · Cited by 33

The FLT3 inhibitor PKC412 exerts differential cell cycle effects on leukemic cells depending on the presence of FLT3 mutations

Odgerel, T., Kikuchi, J., Wada, T., Shimizu, R., Futaki, K., Kano, Y., & Furukawa, Y. (2007) · Oncogene · doi:10.1038/sj.onc.1210980 · Cited by 32

Targeting FMS-like tyrosine kinase 3 (FLT3) in acute myeloid leukemia: Novel molecular approaches and therapeutic challenges

Rataj, J., Górecki, L., Muthná, D., Sorf, A., Kryštof, V., Klener, P., Čečková, M., Řezáčová, M., & Korábečný, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117788 · Cited by 32

Chronic Expression of Murine flt3 Ligand in Mice Results in Increased Circulating White Blood Cell Levels and Abnormal Cellular Infiltrates Associated With Splenic Fibrosis

Juan, T., McNiece, I., Van, G., Lacey, D. L., Hartley, C. A., McElroy, P. L., Sun, Y. S., Argento, J., Hill, D., Yan, X.-Q., et al. (1997) · Blood · doi:10.1182/blood.v90.1.76 · Cited by 31

Flt3 Ligand Enhances the Yield of Primitive Cells After Ex Vivo Cultivation of CD34+ CD38dim Cells and CD34+ CD38dim CD33dim HLA-DR+ Cells

Dooley, D. C., Xiao, M., Oppenlander, B. K., Plunkett, J. M., & Lyman, S. D. (1997) · Blood · doi:10.1182/blood.v90.10.3903 · Cited by 31

Developments and challenges of FLT3 inhibitors in acute myeloid leukemia

Ge, S., Liu, S., & Xue, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.996438 · Cited by 30

The meaning of the c-kit proto-oncogene product in malignant transformation in human mammary epithelium

Ko, C. D., Kim, J. S., Ko, B., Son, B. H., Kang, H. J., Yoon, H. S., Cho, E. Y., Gong, G., & Ahn, S. H. (2003) · Clinical & Experimental Metastasis · doi:10.1023/a:1027323210736 · Cited by 30

Molecular research directions in the management of gastrointestinal stromal tumors

Tarn, C., & Godwin, A. K. (2005) · Current Treatment Options in Oncology · doi:10.1007/s11864-005-0026-x · Cited by 30

Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model

Agrawal, D. K., Hopfenspirger, M. T., Chavez, J. M., & Talmadge, J. E. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00122-9 · Cited by 30

FLT3/FLK‐2 (STK‐1) Ligand Does Not Stimulate Human Megakaryopoiesis In Vitro

Ratajczak, M. Z., Ratajczak, J., Ford, J. C., Kregenow, R., Marlicz, W. M., & Gewirtz, A. M. (1996) · Stem Cells · doi:10.1002/stem.140146 · Cited by 22

Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells

Zeigler, F., Bennett, B., Jordan, C. T., Spencer, S., Baumhueter, S., Carroll, K., Hooley, J., Bauer, K., & Matthews, W. (1994) · Blood · doi:10.1182/blood.v84.8.2422.2422 · Cited by 137

Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells

Iwama, A., Okano, K., Sudo, T., Matsuda, Y., & Suda, T. (1994) · Blood · doi:10.1182/blood.v83.11.3160.3160 · Cited by 143

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

Matthews, W., Jordan, C. T., Wiegand, G. W., Pardoll, D., & Lemischka, I. R. (1991) · Cell · doi:10.1016/0092-8674(91)90010-v · Cited by 593

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.

Matthews, W., Jordan, C. T., Gavin, M. A., Jenkins, N. A., Copeland, N. G., & Lemischka, I. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9026 · Cited by 502