STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

DNA sequencing with chain-terminating inhibitors

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

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A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

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“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

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Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

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The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

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Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

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Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

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Purification and Characterization of Mouse Hematopoietic Stem Cells

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Translating insights from normal, neoplastic hematopoiesis and myeloid disease progression into potential clinical applications

Lim, Y. (2014)

Overcoming the Protective Effect of the Bone Marrow Microenvironment by Dual FLT3 and BET Inhibition in FLT3-ITD Acute Myeloid Leukemia

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Target Therapy in Acute Myeloid Leukemia

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Impact of Conditioning Regimen Choice: The Role of Dendritic Cells in Graft-Versus-Host Disease

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Live and Let Die : Critical regulation of survival in normal and malignant hematopoietic stem and progenitor cells

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The Use of Cytokines to Enhance Collection of Stem Cells for Marrow and Blood Transplantation

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Prospects for Gene Therapy of Inherited Immunodeficiency

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Protein-tyrosine kinase (PTK, not ETK, WZC)

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Faculty Opinions recommendation of Cutting edge molecular therapy for acute myeloid leukemia.

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Receptor protein-tyrosine kinase

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Oncogenes

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FLT3 ligand

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Cloning, expression and purification of the cytokine FLT3-ligand for protein interaction studies

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The c-myb Protooncogene: A Novel Target for Human Gene Therapy

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Oligonucleotide Therapeutics for Human Leukaemia

Gewirtz, A. M. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515396.ch13

Flt3 L

Fitzgerald, K. A., O'Neill, L. A. J., Gearing, A. J. H., & Callard, R. E. (2001) · Elsevier eBooks · doi:10.1016/b978-012155142-1/50051-8

Modelo experimental para la evaluación del nicho medular influencia de las células madre mesenquimales sobre características fenotípicas y funcionales de células madre hematopoyéticas y células leucémicas

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Successful treatment of relapsed FLT3-mutated donor cell-derived MDS/AML with FLT3 inhibitor gilteritinib

Kawano, M., Kunimoto, H., Izumi, A., Adachi, A., Miura, A., Yokoyama, C., Hasegawa, K., Shirafuta, M., Tanaka, M., Sakuma, T., et al. (2026) · Annals of Hematology · doi:10.1007/s00277-026-06896-3

Phase Ia study to evaluate RO7497987, a FLT3L-fragment Fc fusion protein, in healthy volunteers

Iacovelli, A. J., Sanjabi, S., Monemi, S., Amitai, A., Decalf, J., Moussion, C., Liao, M. Z., Rao, G. K., Getz, J., & Mancuso, M. R. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1784546

Immunopathology of primary Sjögren’s syndrome (role of B lymphocyte, FLT3 ligand and BAFF) and the clinical consequences

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Role of the Bone Morphogenetic Proteins pathway in tyrosine kinase inhibitors resistance in Chronic Myeloid Leukemia

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Developmental origins of the ETO2 : GLIS2 - driven acute megakaryoblastic leukemia in humans and role of the cytokine microenvironment in leukemogenesis

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Treatment sequence with gilteritinib and allogeneic haematopoietic stem cell transplantation in relapsed/refractory FMS‐like tyrosine kinase 3 ( FLT3 )‐mutated acute myeloid leukaemia patients: A multicentre real‐world study

Kunadt, D., Zukunft, S., Röllig, C., Metzelder, S., Burchert, A., Wagner‐Drouet, E., Kriege, O., Schliemann, C., Stelljes, M., Ronnacker, J., et al. (2026) · British Journal of Haematology · doi:10.1111/bjh.70735

FLT3 expression and immune-associated transcriptional signatures in prostate cancer

Cui, Y., 宋添谋, Wang, X., Wan, Z., & Mao, L. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1970520

BindingDB Entry 50020775: 4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors.

BindingDB (2009) · UC San Diego · doi:10.7270/q2t72h47

BindingDB Entry 50008955: Discovery of thiazolidin-4-one urea analogues as novel multikinase inhibitors that potently inhibit FLT3 and VEGFR2.

BindingDB (2021) · UC San Diego · doi:10.7270/q27p92tp

BindingDB Entry 50011847: A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia.

BindingDB (2022) · UC San Diego · doi:10.7270/q25h7kwp

BindingDB Entry 50049090: Synthetic strategy for increasing solubility of potential FLT3 inhibitor thieno[2,3-d]pyrimidine derivatives through structural modifications at the C

BindingDB (2019) · UC San Diego · doi:10.7270/q2sf2zfd

BindingDB Entry 50044947: Design, synthesis and biological evaluation of FLT3 covalent inhibitors with a resorcylic acid core.

BindingDB (2016) · UC San Diego · doi:10.7270/q2c53ng1

BindingDB Entry 50018172: Design, synthesis, and evaluation of pyrido.[3,4-b]pyrazin-2(1H)-one derivatives as potent FLT3 inhibitors.

BindingDB (2024) · UC San Diego · doi:10.7270/q2qz2g5k

Running Title: Role of Cbl mutations in myeloid transformation

Sargin, B., Choudhary, C., Crosetto, N., Grundler, R., Rensinghoff, M., Thiessen, C., Tickenbrock, L., Schwäble, J., Brandts, C., August, B. K., et al. (2013)

FLT3/FLK‐2 (STK‐1) Ligand Does Not Stimulate Human Megakaryopoiesis In Vitro

Ratajczak, M. Z., Ratajczak, J., Ford, J. C., Kregenow, R., Marlicz, W. M., & Gewirtz, A. M. (1996) · Stem Cells · doi:10.1002/stem.140146 · Cited by 22

Cellular and molecular characterization of the role of the flk-2/flt-3 receptor tyrosine kinase in hematopoietic stem cells

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Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells

Iwama, A., Okano, K., Sudo, T., Matsuda, Y., & Suda, T. (1994) · Blood · doi:10.1182/blood.v83.11.3160.3160 · Cited by 143

A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

Matthews, W., Jordan, C. T., Wiegand, G. W., Pardoll, D., & Lemischka, I. R. (1991) · Cell · doi:10.1016/0092-8674(91)90010-v · Cited by 593

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.

Matthews, W., Jordan, C. T., Gavin, M. A., Jenkins, N. A., Copeland, N. G., & Lemischka, I. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9026 · Cited by 502