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Cited by 621

The DOI matches its Crossref record.

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

Open access
Masters, B A, Kelly, E J, Quaife, C J, Brinster, R L, Palmiter, R D·1994·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.91.2.584
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Abstract

We inactivated the mouse metallothionein (MT)-I and MT-II genes in embryonic stem cells and generated mice homozygous for these mutant alleles. These mice were viable and reproduced normally when reared under normal laboratory conditions. They were, however, more susceptible to hepatic poisoning by cadmium. This proves that these widely expressed MTs are not essential for development but that they do protect against cadmium toxicity. These mice provide a means for testing other proposed functions of MT in vivo.

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Metadata

Authors
Masters, B. A., Kelly, E. J., Quaife, C. J., Brinster, R. L., & Palmiter, R. D.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1994-01-18
Volume
91
Issue
2
Pages
584-588
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.91.2.584
OpenAlex
W1992256486
Cited by
621
References
0
FWCI
39.14
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. https://app.cochat.ai/papers/10.1073/pnas.91.2.584
The paper
Masters, B. A., Kelly, E. J., Quaife, C. J., Brinster, R. L., & Palmiter, R. D. (1994). Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.2.584

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.