The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CD8+ T cells in psoriatic lesions preferentially use T-cell receptor V beta 3 and/or V beta 13.1 genes.
Open accessAbstract
Psoriasis is an inflammatory skin disorder characterized by epidermal keratinocyte hyperproliferation in association with a cellular infiltrate. There is evidence that activated T cells play a role in psoriatic plaque formation. We examined the T-cell receptor beta-chain variable gene segment (V beta) use of epidermal T cells in shave biopsies of psoriatic lesions. Our results show increased expression of V beta 3 and/or V beta 13.1 messages in the CD8+, but not CD4+, T cells in the lesions of a majority of patients studied. Sequence analysis of complementarity-determining region 3 (CDR3) of these two V beta genes from the skin demonstrated monoclonality or marked oligoclonality. A second biopsy from the same or different lesions, performed 3.5-8 months later in four patients, again revealed increased V beta 3 and/or V beta 13.1 expression and clonality. Moreover, in three of the four patients, the same V beta CDR3 rearrangement was found in both biopsies, although there was no V beta CDR3 homology between patients. In two patients in which V beta 3 and/or V beta 13.1 was not increased, an increase in V beta 17 gene use and clonality was found. The clonality of V beta sequence data indicates these cells are recruited and expanded in situ. The persistence of V beta 3-and/or V beta 13.1-bearing CD8+ T cells in lesions that did not undergo resolution suggests their role as effector cells rather than as regulatory cells.
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Human epidermal T cells predominantly belong to the lineage expressing alpha/beta T cell receptor.
Foster, C. A., Yokozeki, H., Rappersberger, K., Koning, F., Volc-Platzer, B., Rieger, A., Coligan, J. E., Wolff, K., & Stingl, G. (1990) · The Journal of experimental medicine · doi:10.1084/jem.171.4.997 · Cited by 182
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Ozawa, M., Ferenczi, K., Kikuchi, T., Cardinale, I., Austin, L. M., Coven, T. R., Burack, L. H., & Krueger, J. G. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.711 · Cited by 298
α1β1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis
Conrad, C., Boyman, O., Tonel, G., Tun-Kyi, A., Laggner, U., de Fougerolles, A., Kotelianski, V., Gardner, H., & Nestle, F. O. (2007) · Nature Medicine · doi:10.1038/nm1605 · Cited by 265
Metadata
- Authors
- Chang, J. C., Smith, L. R., Froning, K. J., Schwabe, B. J., Laxer, J. A., Caralli, L. L., Kurland, H. H., Karasek, M. A., Wilkinson, D. I., & Carlo, D. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-09-27
- Volume
- 91
- Issue
- 20
- Pages
- 9282-9286
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2038226782
- Cited by
- 232
- References
- 1
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: CD8+ T cells in psoriatic lesions preferentially use T-cell receptor V beta 3 and/or V beta 13.1 genes. https://app.cochat.ai/papers/10.1073/pnas.91.20.9282
- The paper
- Chang, J. C., Smith, L. R., Froning, K. J., Schwabe, B. J., Laxer, J. A., Caralli, L. L., Kurland, H. H., Karasek, M. A., Wilkinson, D. I., & Carlo, D. J. (1994). CD8+ T cells in psoriatic lesions preferentially use T-cell receptor V beta 3 and/or V beta 13.1 genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.20.9282
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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