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Molecular cloning of a functional human galanin receptor.
Open accessAbstract
The ubiquitous neuropeptide galanin controls numerous functions such as endocrine secretions, intestinal motility, and behavioral activities. These regulatory effects of galanin are mediated through the interaction with specific membrane receptors and involve the pertussis toxin-sensitive guanine nucleotide binding proteins Gi/Go as transducing elements. We report here the isolation of a cDNA coding for a human galanin receptor from a Bowes melanoma cell line cDNA expression library, by using a radioligand binding strategy. The nucleotide sequence of the cloned receptor reveals an open reading frame encoding a 349-amino acid protein with seven putative hydrophobic transmembrane domains and significant homology with members of the guanine nucleotide binding protein-coupled neuropeptide receptor family. The cloned receptor expressed in COS cells specifically binds human, porcine, and rat galanin with high affinity (Kd in the nanomolar range) and mediates the galanin inhibition of adenylate cyclase. A 2.8-kb galanin receptor transcript was identified in several human tissues. Cloning of this galanin receptor should enhance our knowledge of its distribution, structure, and function in human physiology and pathophysiology.
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Cited by
Lang, R., Gundlach, A. L., Holmes, F. E., Hobson, S. A., Wynick, D., Hökfelt, T., & Kofler, B. (2015) · Pharmacological Reviews · doi:10.1124/pr.112.006536 · Cited by 327
Holmes, A., Kinney, J. W., Wrenn, C. C., Li, Q., Yang, R. J., Ma, L., Vishwanath, J., Saavedra, M. C., Innerfield, C. E., Jacoby, A. S., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300164 · Cited by 202
Neuropeptide and small transmitter coexistence: Fundamental studies and relevance to mental illness
Hökfelt, T., Barde, S., Xu, Z.-Q. D., Kuteeva, E., Rüegg, J., Le Maitre, E., Risling, M., Kehr, J., Ihnatko, R., Theodorsson, E., et al. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00106 · Cited by 139
Galanin receptor-mediated inhibition of glutamate release in the arcuate nucleus of the hypothalamus
Kinney, G. A., Emmerson, P. J., & Miller, R. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03489.1998 · Cited by 81
Nilsson, C. L., Brinkmalm, A., Minthon, L., Blennow, K., & Ekman, R. (2001) · Peptides · doi:10.1016/s0196-9781(01)00571-x · Cited by 79
Metadata
- Authors
- Habert-Ortoli, E., Amiranoff, B., Loquet, I., Laburthe, M., & Mayaux, J. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-10-11
- Volume
- 91
- Issue
- 21
- Pages
- 9780-9783
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2004465233
- Cited by
- 340
- References
- 0
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Habert-Ortoli, E., Amiranoff, B., Loquet, I., Laburthe, M., & Mayaux, J. F. (1994). Molecular cloning of a functional human galanin receptor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.21.9780
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