Neuropeptide and small transmitter coexistence: Fundamental studies and relevance to mental illness

Hökfelt, Tomas; Barde, Swapnali; Xu, Zhi-Qing David; Kuteeva, Eugenia; Rüegg, Joelle; Le Maitre, Erwan; Risling, Mårten; Kehr, Jan; Ihnatko, Robert; Theodorsson, Elvar; Palkovits, Miklos; Deakin, William; Bagdy, Gyorgy; Juhasz, Gabriella; Prud’homme, H. Josée; Mechawar, Naguib; Diaz-Heijtz, Rochellys; Ögren, Sven Ove

doi:10.3389/fncir.2018.00106

Cited by 139Neuropeptides and Animal PhysiologyStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Neuropeptide and small transmitter coexistence: Fundamental studies and relevance to mental illness

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Hökfelt, Tomas, Barde, Swapnali, Xu, Zhi-Qing David, Kuteeva, Eugenia, Rüegg, Joelle, Le Maitre, Erwan, Risling, Mårten, Kehr, Jan +10 more·2018·Frontiers in Neural Circuits

DOI 10.3389/fncir.2018.00106PMC PMC6309708

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Abstract

Neuropeptide are auxiliary messenger molecules that always co-exist in nerve cells with one or more small-molecule (classic) neurotransmitters. Neuropeptides act both as transmitters and trophic factors, and play a role especially when the nervous system is challenged, as by injury, pain or stress. Here neuropeptides and coexistence in mammals are reviewed, but with special focus on the 29/30 amino acid galanin and its three receptors GalR1, -R2 and -R3. In particular, galanin’s role as a co-transmitter in both rodent and human noradrenergic locus coeruleus (LC) neurons is addressed. Extensive experimental animal data strongly suggest a role for the galanin system in depression–like behavior. The translational potential of these results was tested by studying the galanin system in human postmortem brains, first normal brains, and then by comparing five regions of brains obtained from depressed people who committed suicide, and from matched controls. It is hypothesized that, when exposed to severe stress, the noradrenergic LC neurons fire in bursts and release galanin from their soma/dendrites. Galanin then acts on somato-dendritic, inhibitory GalR3 autoreceptors, opening potassium channels and inhibiting firing. The purpose of these autoreceptors is to act as a ‘brake’ to prevent overexcitation, a brake that also is part of resilience to stress that protects against depression. Depression then arises when the inhibition is too strong and long lasting - a maladaption, allostatic load, leading to depletion of NA levels in the forebrain. It is suggested that disinhibition by a galanin GalR3 antagonist may have antidepressant activity by restituting forebrain NA levels. A role of galanin in depression is also supported by a recent candidate gene study, showing that variants in genes for galanin and its three receptors confer increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events. Taken together, the neuropeptide galanin, coexisting in LC neurons, may participate in the mechanism underlying resilience against a serious and common disorder, MDD. These results may lead to an increased understanding of how this illness develops which in turn can provide a basis for its treatment.

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Diverse neuropeptides are expressed and released in regions of anxiety/fear neurocircuitries, often together with classical transmitters.
“Diverse neuropeptides are expressed and released in regions of anxiety/fear neurocircuitries, often together with classical transmitters (Hökfelt et al., 2018).”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Hökfelt et al., 2018

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Continuous cultures of fused cells secreting antibody of predefined specificity
Köhler, G., & Milstein, C. (1975) · Nature · doi:10.1038/256495a0 · Cited by 17,200 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572 · see citing works
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501 · see citing works
Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works
EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.
Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,143 · see citing works
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 4,981 · cited 16× · see citing works
“A very large GWAS failed to identify risk genes (Major Depressive Disorder Working Group of the Psychiatric Gwas Consortium, 2013), but recent advances in large MDD GWAS studies resulted in several SNPs being associated with MDD (e.g., Hyde et al., 2016; Okbay et al., 2016; Xiao et al., 2017; Wray et al., 2018), and p…”
BackgroundInfluential
DNA methylation and its basic function
Moore, L. D., Le, T., & Fan, G. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.112 · Cited by 4,906 · see citing works
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621 · see citing works
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · see citing works
Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965 · see citing works
Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904 · see citing works
Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice
Trivedi, M. H., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., Warden, D., Ritz, L., Norquist, G., Howland, R. H., Lebowitz, B., McGrath, P. J., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.28 · Cited by 3,879 · see citing works
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878 · see citing works
Stereotaxic mapping of the monoamine pathways in the rat brain
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb10998.x · Cited by 3,819 · see citing works
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806 · see citing works
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works
The size and burden of mental disorders and other disorders of the brain in Europe 2010
Wittchen, H. U., Jacobi, F., Rehm, J., Gustavsson, A., Svensson, M., Jönsson, B., Olesen, J., Allgulander, C., Alonso, J., Faravelli, C., et al. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.018 · Cited by 3,754 · see citing works
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
Brazeau, P., Vale, W., Burgus, R. C., LING, N. C., Butcher, M., Rivier, J., & Guillemin, R. (1973) · Science · doi:10.1126/science.179.4068.77 · Cited by 3,536 · see citing works
THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE
Schildkraut, J. J. (1965) · American Journal of Psychiatry · doi:10.1176/ajp.122.5.509 · Cited by 3,499 · see citing works
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431 · see citing works
Neurobiology of Depression
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
Burden of depressive disorders by country, sex, age, and year: findings from the Global Burden of Disease Study 2010
Ferrari, A. J., Charlson, F. J., Norman, R. E., Patten, S. B., Freedman, G., Murray, C. J. L., Vos, T., & Whiteford, H. A. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001547 · Cited by 3,115 · see citing works
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
eQTLGen, Wray, N. R., 23andMe, the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0090-3 · Cited by 3,005 · see citing works
FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE
FALCK, B., Hillarp, N. ‐., THIEME, G., & Torp, A. (1962) · Journal of Histochemistry & Cytochemistry · doi:10.1177/10.3.348 · Cited by 2,697 · see citing works
Trends in GPCR drug discovery: new agents, targets and indications
Hauser, A. S., Attwood, M. M., Rask‐Andersen, M., Schiöth, H. B., & Gloriam, D. E. I. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.178 · Cited by 2,609 · see citing works
The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529 · see citing works
A comprehensive map of molecular drug targets
Santos, R., Ursu, O., Gaulton, A., Bento, A. P., Donadi, R. S., Bologa, C. G., Karlsson, A., Al-Lazikani, B., Hersey, A., Oprea, T. I., et al. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.230 · Cited by 2,427 · see citing works
Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Rosenfeld, M. G., Mermod, J.-J., Amara, S. G., Swanson, L. W., Sawchenko, P. E., Rivier, J., Vale, W. W., & Evans, R. M. (1983) · Nature · doi:10.1038/304129a0 · Cited by 2,302 · see citing works
Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide
Tatemoto, K., Carlquist, M., & Mutt, V. (1982) · Nature · doi:10.1038/296659a0 · Cited by 2,254 · see citing works
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works
Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993 · see citing works
Nucleus locus ceruleus: new evidence of anatomical and physiological specificity
Foote, S. L., Bloom, F. E., & Aston-Jones, G. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.3.844 · Cited by 1,901 · see citing works
Purinergic Nerves
Burnstock, G. (1972) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06930-3 · Cited by 1,852 · see citing works
Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress
Charney, D. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.195 · Cited by 1,605 · see citing works
New approaches to antidepressant drug discovery: beyond monoamines
Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589 · see citing works
An unidentified depressor substance in certain tissue extracts
von Euler, U. S., & Gaddum, J. H. (1931) · The Journal of Physiology · doi:10.1113/jphysiol.1931.sp002763 · Cited by 1,584 · see citing works
Peptidergic neurones
Hökfelt, T. G. M., Johansson, O., Ljungdahl, Å., Lundberg, J. M., & Schultzberg, M. (1980) · Nature · doi:10.1038/284515a0 · Cited by 1,552 · see citing works
Galanin — a novel biologically active peptide from porcine intestine
Tatemoto, K., Rökaeus, Å., Jörnvall, H., McDonald, T. J., & Mutt, V. (1983) · FEBS Letters · doi:10.1016/0014-5793(83)80033-7 · Cited by 1,490 · see citing works
The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine‐ B ‐hydroxylase as a marker
Swanson, L. W., & Hartman, B. K. (1975) · The Journal of Comparative Neurology · doi:10.1002/cne.901630406 · Cited by 1,479 · see citing works
Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals
Ljungdahl, Å., Hökfelt, T. G. M., & Nilsson, G. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90116-1 · Cited by 1,434 · see citing works
Central Catecholamine Neuron Systems: Anatomy and Physiology of the Norepinephrine and Epinephrine Systems
Moore, R. Y., & Bloom, F. E. (1979) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.02.030179.000553 · Cited by 1,378 · see citing works
Calcium-binding proteins in the nervous system
Baimbridge, K. G., Celio, M. R., & ROGERS, J. H. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90081-i · Cited by 1,336 · see citing works
Psychobiology and molecular genetics of resilience
Feder, A., Nestler, E. J., & Charney, D. S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2649 · Cited by 1,272 · see citing works
Neurobiology of resilience
Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206 · see citing works
Neuropeptide Y (NPY)‐like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function
Lundberg, J. M., Terenius, L. Y., Hökfelt, T. G. M., Martling, C., Tatemoto, K., Mutt, V., Polak, J. M., Bloom, S. R., & Goldstein, M. (1982) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1982.tb07171.x · Cited by 1,199 · see citing works
Cholinergic and inhibitory synapses in a pathway from motor‐axon collaterals to motoneurones
Eccles, J. C., Fatt, P., & KOKETSU, K. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005226 · Cited by 1,198 · see citing works
The Psychobiology of Depression and Resilience to Stress: Implications for Prevention and Treatment
Southwick, S. M., Vythilingam, M., & Charney, D. S. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143948 · Cited by 1,160 · see citing works
Norepinephrine in Depressive Reactions
Bunney, W. E. (1965) · Archives of General Psychiatry · doi:10.1001/archpsyc.1965.01730060001001 · Cited by 1,154 · see citing works
Cellular localization of brain monoamines.
Carlsson, A. C., FALCK, B., & Hillarp, N. ‐. (1962) · PubMed · Cited by 1,144 · see citing works
Mood disorders and allostatic load
McEwen, B. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00177-x · Cited by 1,135 · see citing works
A mega-analysis of genome-wide association studies for major depressive disorder
Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke, S., Wray, N. R., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Byrne, E. M., Blackwood, D. H. R., Boomsma, D. I., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.21 · Cited by 1,120 · see citing works
Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour
Rivier, J., Spiess, J., Thorner, M. O., & Vale, W. (1982) · Nature · doi:10.1038/300276a0 · Cited by 1,102 · see citing works
Assay of Plasma Insulin in Human Subjects by Immunological Methods
Yalow, R. S., & Berson, S. A. (1959) · Nature · doi:10.1038/1841648b0 · Cited by 1,098 · see citing works
Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain
Ho¨kfelt, T., Fuxé, K., Goldstein, M., & Johansson, O. (1974) · Brain Research · doi:10.1016/0006-8993(74)90143-7 · Cited by 1,093 · see citing works
The anatomy of neuropeptide-y-containing neurons in rat brain
Chronwall, B. M., DiMaggio, D. A., Massari, V. J., Pickel, V. M., Ruggiero, D. A., & O’Donohue, T. L. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90260-x · Cited by 1,088 · see citing works
Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors
Kramer, M. S., Cutler, N. R., Feighner, J. P., Shrivastava, R. K., Carman, J. S., Sramek, J. J., Reines, S. A., Liu, G. F., Snavely, D. B., Wyatt-Knowles, E. S., et al. (1998) · Science · doi:10.1126/science.281.5383.1640 · Cited by 1,071 · see citing works
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059 · see citing works
Substance P: Localization in the Central Nervous System and in Some Primary Sensory Neurons
Hökfelt, T. G. M., Kellerth, J. ‐., Nilsson, G., & Pernow, B. (1975) · Science · doi:10.1126/science.242075 · Cited by 1,024 · see citing works
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Study, L. C., Okbay, A., Baselmans, B. M. L., De Neve, J.-E., Turley, P., Nivard, M. G., Fontana, M. A., Meddens, S. F. W., Linnér, R. K., Rietveld, C. A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3552 · Cited by 1,013 · see citing works
CGRP as the target of new migraine therapies — successful translation from bench to clinic
Edvinsson, L. I., Haanes, K. A., Warfvinge, K., & Krause, D. N. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0003-1 · Cited by 1,010 · see citing works
Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine
Svensson, T. H., Bunney, B. S., & Aghajanian, G. K. (1975) · Brain Research · doi:10.1016/0006-8993(75)90276-0 · Cited by 1,009 · see citing works
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Dendritic peptide release and peptide-dependent behaviours
Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945 · see citing works
Defined types of cortical interneurone structure space and spike timing in the hippocampus
Somogyi, P., & Klausberger, T. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.078915 · Cited by 927 · see citing works
Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.
Hökfelt, T. G. M., Ljungdahl, Å., Terenius, L. Y., Elde, R., & Nilsson, G. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.7.3081 · Cited by 887 · see citing works
Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat
Everitt, B. J., Hökfelt, T. G. M., Terenius, L. Y., Tatemoto, K., Mutt, V., & Goldstein, M. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90036-8 · Cited by 871 · see citing works
Locus coeruleus and dopaminergic consolidation of everyday memory
Takeuchi, T., Duszkiewicz, A. J., Sonneborn, A., Spooner, P. A., Yamasaki, M., Watanabe, M., Smith, C. C., Fernández, G., Deisseroth, K., Greene, R. W., et al. (2016) · Nature · doi:10.1038/nature19325 · Cited by 827 · see citing works
Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system
Hökfelt, T. G. M., Ljungdahl, Å., Steinbusch, H. W. M., Verhofstad, A. A. J., Nilsson, G., Brodin, E., Pernow, B., & Goldstein, M. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90017-9 · Cited by 814 · see citing works
Neuropeptide Transmission in Brain Circuits
van den Pol, A. N. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.014 · Cited by 810 · see citing works
The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
Broberger, C., Johansen, J., Johansson, C., Schalling, M., & Hökfelt, T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15043 · Cited by 798 · see citing works
Fremanezumab for the Preventive Treatment of Chronic Migraine
Silberstein, S. D., Dodick, D. W., BIGAL, M. E., Yeung, P. P., Goadsby, P. J., Blankenbiller, T., Grozinski‐Wolff, M., Yang, R., Ma, Y., & Aycardi, E. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1709038 · Cited by 794 · see citing works
Amino-acid Sequence of Substance P
CHANG, M. M., Leeman, S. E., & Niall, H. D. (1971) · Nature New Biology · doi:10.1038/newbio232086a0 · Cited by 790 · see citing works
Corelease of Two Fast Neurotransmitters at a Central Synapse
Jonas, P., Bischofberger, J., & Sandkühler, J. (1998) · Science · doi:10.1126/science.281.5375.419 · Cited by 784 · see citing works
Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
Hyde, C. L., Nagle, M. W., Tian, C., Chen, X., Paciga, S. A., Wendland, J. R., Tung, J. Y., Hinds, D. A., Perlis, R. H., & Winslow, A. R. (2016) · Nature Genetics · doi:10.1038/ng.3623 · Cited by 784 · see citing works
Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides1Published on the World Wide Web on 17 August 1999.1
Seidah, N. G., & Chrétien, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01909-5 · Cited by 760 · see citing works
Sex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748 · see citing works
Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers
Ekblad, E., Edvinsson, L. I., Wahlestedt, C., Uddman, R., Håkanson, R., & Sundler, F. (1984) · Regulatory Peptides · doi:10.1016/0167-0115(84)90064-8 · Cited by 741 · see citing works
Distribution of galaninlike immunoreactivity in the rat central nervous system
Melander, T., Hökfelt, T. G. M., & Rökaeus, Å. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902480404 · Cited by 724 · see citing works
A subpopulation of mesencephalic dopamine neurons projecting to limbic areas contains a cholecystokinin-like peptide: Evidence from immunohistochemistry combined with retrograde tracing
Ho¨kfelt, T., Skirboll, L. R., Rehfeld, J. F., Goldstein, M., MARKEY, K., & Dann, O. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90127-x · Cited by 716 · see citing works
Calcium-binding proteins: selective markers of nerve cells
Andressen, C., Bl�mcke, I., & Celio, M. R. (1993) · Cell and Tissue Research · doi:10.1007/bf00318606 · Cited by 701 · see citing works
Isolation of a Sialogogic Peptide from Bovine Hypothalamic Tissue and Its Characterization as Substance P
Chang, M. M., & Leeman, S. E. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62860-1 · Cited by 699 · see citing works
The Demonstration of Pneumococcal Antigen in Tissues by the Use of Fluorescent Antibody
Coons, A. H., Creech, H. J., Jones, R. N., & Berliner, E. (1942) · The Journal of Immunology · doi:10.4049/jimmunol.45.3.159 · Cited by 674 · see citing works
Oligomerization of G-protein-coupled transmitter receptors
Bouvier, M. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067575 · Cited by 668 · see citing works
Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides
Tatemoto, K., & Mutt, V. (1980) · Nature · doi:10.1038/285417a0 · Cited by 663 · see citing works
Effects of substance P on functionally identified units in cat spinal cord
Henry, J. L. (1976) · Brain Research · doi:10.1016/0006-8993(76)90965-3 · Cited by 660 · see citing works
Behavioral depression produced by an uncontrollable stressor: Relationship to norepinephrine, dopamine, and serotonin levels in various regions of rat brain
Weiss, J. M., Goodman, P. A., Losito, B. G., Corrigan, S. A., Charry, J. M., & Bailey, W. H. (1981) · Brain Research Reviews · doi:10.1016/0165-0173(81)90005-9 · Cited by 660 · see citing works
Immunohistochemical mapping of galanin-like neurons in the rat central nervous system
Skofitsch, G., & Jacobowitz, D. M. (1985) · Peptides · doi:10.1016/0196-9781(85)90118-4 · Cited by 659 · see citing works
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
Choudary, P. V., Molnar, M., Evans, S. J., Tomita, H., Li, J., Vawter, M. P., Myers, R., Bunney, W. E., Akil, H., Watson, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507901102 · Cited by 653 · see citing works
Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory
Kempadoo, K. A., Mosharov, E. V., Choi, S. J., Sulzer, D., & Kandel, E. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616515114 · Cited by 647 · see citing works
Do some nerve cells release more than one transmitter?
Burnstock, G. (1976) · Neuroscience · doi:10.1016/0306-4522(76)90054-3 · Cited by 640 · see citing works
Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxane
Cedarbaum, J. M., & Aghajanian, G. K. (1976) · Brain Research · doi:10.1016/0006-8993(76)90297-3 · Cited by 636 · see citing works
Neuropeptides in perspective: The last ten years
Hökfelt, T. (1991) · Neuron · doi:10.1016/0896-6273(91)90333-u · Cited by 618 · see citing works
The NPY system in stress, anxiety and depression
Heilig, M. A. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.05.002 · Cited by 617 · see citing works
The Regional Distribution of Somatostatin in the Rat Brain
Brownstein, M. J., Arimura, A., SATO, H., Schally, A. V., & Kizer, J. S. (1975) · Endocrinology · doi:10.1210/endo-96-6-1456 · Cited by 594 · see citing works
Galanin neurons in the medial preoptic area govern parental behaviour
Wu, Z., Autry, A. E., Bergan, J. F., Watabe‐Uchida, M., & Dulac, C. G. (2014) · Nature · doi:10.1038/nature13307 · Cited by 592 · see citing works
Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
Li, J. Z., Bunney, B. G., Meng, F., Hagenauer, M. H., Walsh, D. M., Vawter, M. P., Evans, S. J., Choudary, P. V., Cartagena, P., Barchas, J. D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305814110 · Cited by 589 · see citing works
Dopaminergic neurons inhibit striatal output through non-canonical release of GABA
Tritsch, N. X., Ding, J. B., & Sabatini, B. L. (2012) · Nature · doi:10.1038/nature11466 · Cited by 576 · see citing works
Hypothalamic Regulatory Hormones
Schally, A. V., Arimura, A., & Kastin, A. J. (1973) · Science · doi:10.1126/science.179.4071.341 · Cited by 575 · see citing works
Noradrenergic mechanisms in stress and anxiety: I. preclinical studies
Bremner, J., Krystal, J., Southwick, S., & Charney, D. (1996) · Synapse · doi:10.1002/(sici)1098-2396(199605)23:1 · Cited by 571 · see citing works
Epigenetics and the environmental regulation of the genome and its function
Zhang, T.-Y., & Meaney, M. J. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163625 · Cited by 565 · see citing works
Coexistence of peptides and classical neurotransmitters
Lundberg, J. M., & Hökfelt, T. G. M. (1983) · Trends in Neurosciences · doi:10.1016/0166-2236(83)90149-2 · Cited by 562 · see citing works
Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique
Cedarbaum, J. M., & Aghajanian, G. K. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901780102 · Cited by 549 · see citing works
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
Millan, M. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.006 · Cited by 549 · see citing works
Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology
Aston‐Jones, G., Shipley, M., Chouvet, G., Ennis, M. J., Bockstaele, E. V., Pieribone, V. A., Shiekhattar, R., Akaoka, H., Drolet, G., Astier, B., et al. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63799-1 · Cited by 543 · see citing works
The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyroglutamyl-histidyl-proline amide
Bøler, J. B., Enzmann, F., Folkers, K., Bowers, C. Y., & Schally, A. V. (1969) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(69)90868-7 · Cited by 532 · see citing works
Pharmacology of cotransmission in the autonomic nervous system: integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide.
Lundberg, J. (1996) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06937-6 · Cited by 523 · see citing works
Coexistence of galanin-like immunoreactivity with catecholamines, 5- hydroxytryptamine, GABA and neuropeptides in the rat CNS
Melander, T., Hökfelt, T. G. M., Rökaeus, Å., Cuello, A. C., Oertel, W., Verhofstad, A. A. J., & Goldstein, M. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-12-03640.1986 · Cited by 518 · see citing works
The locus coeruleus: A cytoarchitectonic, golgi and immunohistochemical study in the albino rat
Swanson, L. W. (1976) · Brain Research · doi:10.1016/0006-8993(76)90207-9 · Cited by 518 · see citing works
Neuroplasticity in the mesolimbic dopamine system and cocaine addiction
Thomas, M. J., Kalivas, P. W., & Shaham, Y. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.77 · Cited by 513 · see citing works
Light microscope study of the coexistence of GABA‐like and glycine‐like immunoreactivities in the spinal cord of the rat
Todd, A. J., & Sullivan, A. C. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902960312 · Cited by 501 · see citing works
Occurrence of vasoactive intestinal polypeptide (VIP)-like immunoreactivity in certain cholinergic neurons of the cat: Evidence from combined immunohistochemistry and acetylcholinesterase staining
Lundberg, J. M., Hökfelt, T. G. M., Schultzberg, M., Uvnäs‐Wallensten, K., Köhler, C., & Said, S. I. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90018-6 · Cited by 497 · see citing works
Identification of the vasopressin producing and of the oxytocin producing neurons in the hypothalamic magnocellular neurosecretory system of the rat
Vandesande, F., & Dierickx, K. (1975) · Cell and Tissue Research · doi:10.1007/bf00218970 · Cited by 496 · see citing works
Galanin receptor subtypes
Branchek, T. A., Smith, K. E., Gerald, C., & Walker, M. W. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01446-2 · Cited by 495 · see citing works
Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons
Aghajanian, G. K., Cedarbaum, J. M., & Wang, R. Y. (1977) · Brain Research · doi:10.1016/0006-8993(77)90083-x · Cited by 493 · see citing works
Serotonin and substance P coexist in neurons of the rat's central nervous system
Chan‐Palay, V., JONSSON, G., & Palay, S. L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.3.1582 · Cited by 487 · see citing works
Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: Functional significance of coexisting transmitters for vasodilation and secretion
Lundberg, J. M., Änggård, A., Fahrenkrug, J., Hökfelt, T. G. M., & Mutt, V. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1651 · Cited by 482 · see citing works
Receptor Endocytosis and Dendrite Reshaping in Spinal Neurons After Somatosensory Stimulation
Mantyh, P. W., DeMaster, E., Malhotra, A., Ghilardi, Rogers, S. D., Mantyh, C. R., Liu, H., Basbaum, A. I., Vigna, Maggio, J. E., et al. (1995) · Science · doi:10.1126/science.7539937 · Cited by 475 · see citing works
Untitled work
(2005) · PubMed · Cited by 470 · see citing works
Occurrence of somatostatin-like immunoreactivity in some peripheral sympathetic noradrenergic neurons
Hökfelt, T. G. M., Elfvin, L.-G., Elde, R., Schultzberg, M., Goldstein, M., & Luft, R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3587 · Cited by 464 · see citing works
NK1 (substance P) receptor antagonists – why are they not analgesic in humans?
Hill, R. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01502-9 · Cited by 462 · see citing works
Pathways to Regulated Exocytosis in Neurons
Camilli, P. V. D., & Jahn, R. (1990) · Annual Review of Physiology · doi:10.1146/annurev.ph.52.030190.003205 · Cited by 462 · see citing works
CELLULAR LOCALIZATION OF SOMATOSTATIN IN ENDOCRINE-LIKE CELLS AND NEURONS OF THE RAT WITH SPECIAL REFERENCES TO THE A1-CELLS OF THE PANCREATIC ISLETS AND TO THE HYPOTHALAMUS
Hökfelt, T. G. M., Efendić, S., Hellerström, C., Johansson, O., Luft, R., & Arimura, A. (1975) · European Journal of Endocrinology · doi:10.1530/acta.0.080s005 · Cited by 457 · see citing works
Genetic variation in human NPY expression affects stress response and emotion
Zhou, Z., Zhu, G., Hariri, A. R., Enoch, M.-A., Scott, D., Sinha, R., Virkkunen, M., Mash, D. C., Lipsky, R. H., Hu, X.-Z., et al. (2008) · Nature · doi:10.1038/nature06858 · Cited by 455 · see citing works
[The neurosecretory connection between the hypothalamus and the neurohypophysis].
Bargmann, W. (1949) · PubMed · Cited by 455 · see citing works
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans
Samuels, E., & Szabadi, E. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777193 · Cited by 454 · see citing works
Detection of viral sequences of low reiteration frequency by in situ hybridization.
Brahic, M., & Haase, A. T. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.12.6125 · Cited by 454 · see citing works
Regional distribution of substance P in the spinal cord and nerve roots of the cat and the effect of dorsal root section
Takahashi, T., & Otsuka, M. (1975) · Brain Research · doi:10.1016/0006-8993(75)90774-x · Cited by 447 · see citing works
Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned
Wray, N. R., Pergadia, M. L., Blackwood, D. H. R., Penninx, B. W. J. H., Gordon, S. D., Nyholt, D. R., Ripke, S., MacIntyre, D. J., McGhee, K. A., Maclean, A. W., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2010.109 · Cited by 444 · see citing works
Treatment resistant depression: A multi-scale, systems biology approach
Akil, H., Gordon, J. A., Hen, R., Javitch, J. A., Mayberg, H. S., McEwen, B. S., Meaney, M. J., & Nestler, E. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.019 · Cited by 443 · see citing works
Increase of galanin-like immunoreactivity in rat dorsal root ganglion cells after peripheral axotomy
Hökfelt, T. G. M., Wiesenfeld‐Hallin, Z., Villar, M. J., & Melander, T. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90088-7 · Cited by 442 · see citing works
A galanin-like peptide in the central nervous system and intestine of the rat
Rökaeus, Å., Melander, T., Hökfelt, T. G. M., Lundberg, J. M., Tatemoto, K., Carlquist, M., & Mutt, V. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90423-3 · Cited by 436 · see citing works
Chemical transmission between rat sympathetic neurons and cardiac myocytes developing in microcultures: evidence for cholinergic, adrenergic, and dual-function neurons.
Furshpan, E. J., MacLeish, P. R., O'Lague, P. H., & Potter, D. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.4225 · Cited by 432 · see citing works
Orexin (Hypocretin) Neurons Contain Dynorphin
Chou, T. C., Lee, C. E., Lü, J., Elmquist, J. K., Hara, J., Willie, J. T., Beuckmann, C. T., Chemelli, R. M., Sakurai, T., Yanagisawa, M., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-j0003.2001 · Cited by 430 · see citing works
Depressant action of TRH, LH-RH and somatostatin on activity of central neurones
Renaud, L. P., Martin, J. B., & Brazeau, P. (1975) · Nature · doi:10.1038/255233a0 · Cited by 429 · see citing works
Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder
Aston, C., Jiang, L., & Sokolov, B. P. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001565 · Cited by 427 · see citing works
Primary structure of corticotropin-releasing factor from ovine hypothalamus
Spiess, J., Rivier, J., Rivier, C., & Vale, W. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6517 · Cited by 424 · see citing works
Dysregulation of the fibroblast growth factor system in major depression
Evans, S. J., Choudary, P. V., Neal, C. R., Li, J. Z., Vawter, M. P., Tomita, H., Lopez, J. F., Thompson, R. C., Meng, F., Stead, J. D., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406788101 · Cited by 424 · see citing works
Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics
Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-053013-062946 · Cited by 422 · see citing works
50 years of hurdles and hope in anxiolytic drug discovery
Griebel, G., & Holmes, A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4075 · Cited by 414 · see citing works
Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6
Chen, N., Reith, M. E. A., & Quick, M. W. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1064-5 · Cited by 411 · see citing works
Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo
Hnasko, T. S., Chuhma, N., Zhang, H., Goh, G. Y., Sulzer, D., Palmiter, R. D., Rayport, S., & Edwards, R. H. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.012 · Cited by 405 · see citing works
Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders
Holmes, A., Heilig, M. A., Rupniak, N. M. J., Steckler, T., & Griebel, G. (2003) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2003.09.011 · Cited by 401 · see citing works
Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2
Peña, C. J., Kronman, H. G., Walker, D. M., Cates, H. M., Bagot, R. C., Purushothaman, I., Issler, O., Loh, Y.-H. E., Leong, T., Kiraly, D. D., et al. (2017) · Science · doi:10.1126/science.aan4491 · Cited by 394 · see citing works
The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments
Mongeau, R., Blier, P., & de Montigny, C. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00017-3 · Cited by 391 · see citing works
Peptidergic transmission in sympathetic ganglia of the frog.
Jan, L. Y., & Jan, Y. N. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014228 · Cited by 390 · see citing works
Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression
Sequeira, A., Mamdani, F., Ernst, C., Vawter, M. P., Bunney, W. E., Lebel, V., Rehal, S., Klempan, T., Gratton, A., Benkelfat, C., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006585 · Cited by 388 · see citing works
Electron Microscopic Identification of Autonomic Nerve Endings
RICHARDSON, K. C. (1966) · Nature · doi:10.1038/210756a0 · Cited by 381 · see citing works
Characterization of Ovine Hypothalamic Hypophysiotropic TSH-releasing Factor
Burgus, R. C., Dunn, T. F., Desiderio, D. M., Ward, D. N., Vale, W., & Guillemin, R. (1970) · Nature · doi:10.1038/226321a0 · Cited by 379 · see citing works
The site of origin of the hormones of the posterior pituitary.
Bargmann, W., & Scharrer, E. (1951) · PubMed · Cited by 379 · see citing works
Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. I. Acutely presented stressful and nonstressful stimuli
Abercrombie, E., & Jacobs, B. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-09-02837.1987 · Cited by 377 · cited 2× · see citing works
“…the LC: stress increases NA turnover, as well as tyrosine hydroxylase activity and transcription in the LC (Korf et al., 1973; Zigmond et al., 1974; Abercrombie and Jacobs, 1987; Komori et al., 1990; Smith et al., 1991; Melia et al., 1992; Aston-Jones et al., 1996; Rusnak et al., 1998; Chang et…”
Background
The galanin peptide family: Receptor pharmacology, pleiotropic biological actions, and implications in health and disease
LANG, R., Gundlach, A. L., & Kofler, B. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.05.009 · Cited by 376 · see citing works
Distribution of dopamine‐, noradrenaline‐, and adrenaline‐containing cell bodies in the rat medulla oblongata: Demonstrated by the immunocytochemical localization of catecholamine biosynthetic enzymes
Armstrong, D. M., Ross, C. A., Pickel, V. M., JOH, T. H., & Reis, D. J. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902120207 · Cited by 375 · see citing works
Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression
Bernard, R., Kerman, I. A., Thompson, R. C., Jones, E. G., Bunney, W. E., Barchas, J. D., Schatzberg, A. F., Myers, R. M., Akil, H., & Watson, S. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.44 · Cited by 372 · see citing works
Characterization of rat hypothalamic growth hormone-releasing factor
Spiess, J., Rivier, J., & Vale, W. (1983) · Nature · doi:10.1038/303532a0 · Cited by 372 · see citing works
Locus coeruleus neurons in the rat containing neuropeptide Y, tyrosine hydroxylase or galanin and their efferent projections to the spinal cord, cerebral cortex and hypothalamus
Holets, V. R., Hökfelt, T. G. M., Rökaeus, Å., Terenius, L. Y., & Goldstein, M. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90076-0 · Cited by 368 · see citing works
Cortical gamma band synchronization through somatostatin interneurons
Veit, J., Hakim, R., Jadi, M. P., B, T. J. S. A., & Adesnik, H. (2017) · Nature Neuroscience · doi:10.1038/nn.4562 · Cited by 364 · see citing works
The dappled nature of causes of psychiatric illness: replacing the organic–functional/hardware–software dichotomy with empirically based pluralism
Kendler, K. S. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.182 · Cited by 363 · see citing works
H 2 S: A Novel Gasotransmitter that Signals by Sulfhydration
Paul, B. D., & Snyder, S. H. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.08.007 · Cited by 361 · see citing works
Tachykinin-Expressing Neurons Control Male-Specific Aggressive Arousal in Drosophila
Asahina, K., Watanabe, K., Duistermars, B. J., Hoopfer, E. D., González, C. R., Eyjólfsdóttir, E., Perona, P., & Anderson, D. J. (2014) · Cell · doi:10.1016/j.cell.2013.11.045 · Cited by 358 · see citing works
The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y
Kask, A., Harro, J., von Hörsten, S., Redrobe, J. P., Dumont, Y., & Quirion, R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00066-5 · Cited by 358 · see citing works
Isolation and structural organization of the human preproenkephalin B gene
Horikawa, S., Takai, T., Toyosato, M., Takahashi, H., Noda, M., Kakidani, H., Kubo, T., Hirose, T., Inayama, S., Hayashida, H., et al. (1983) · Nature · doi:10.1038/306611a0 · Cited by 352 · see citing works
Characterization of hippocampal norepinephrine release as measured by microdialysis perfusion: pharmacological and behavioral studies.
Abercrombie, E., Keller, R., & Zigmond, M. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90192-3 · Cited by 342 · see citing works
Molecular cloning of a functional human galanin receptor.
Habert, E., Amiranoff, B., Loquet, I., Laburthe, M., & Mayaux, J. F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9780 · Cited by 340 · see citing works
Serotonin Release as a Possible Mechanism of Reserpine Action
Pletscher, A., Shore, P. A., & Brodie, B. B. (1955) · Science · doi:10.1126/science.122.3165.374 · Cited by 336 · see citing works
Differential release of amino acids, neuropeptides, and catecholamines from isolated nerve terminals
Verhage, M., McMahon, H. T., Ghijsen, W. E. J. M., Boomsma, F., Scholten, G., Wiegant, V. M., & Nicholls, D. G. (1991) · Neuron · doi:10.1016/0896-6273(91)90054-4 · Cited by 335 · see citing works
Neuropeptides: opportunities for drug discovery
Hökfelt, T. G. M., Bartfai, T., & Bloom, F. E. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00482-4 · Cited by 333 · see citing works
Coexistence of peptides with classical neurotransmitters
Hökfelt, T. G. M., Millhorn, D. E., Seroogy, K. B., Tsuruo, Y., Ceccatelli, S., Lindh, B., Meister, B., Melander, T., Schalling, M., Bartfai, T., et al. (1987) · Cellular and Molecular Life Sciences · doi:10.1007/bf01945354 · Cited by 332 · see citing works
Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders
Iwamoto, K., Kakiuchi, C., Bundo, M., Ikeda, K., & Kato, T. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001437 · Cited by 331 · see citing works
Anatomy and physiology of central galanin-containing pathways
Merchenthaler, I., LÓPEZ, F. J., & Negro-Vilar, A. F. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90012-h · Cited by 331 · see citing works
Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity
Lang, R., Gundlach, A. L., Holmes, F. E., Hobson, S. A., Wynick, D., Hökfelt, T., & Kofler, B. (2015) · Pharmacological Reviews · doi:10.1124/pr.112.006536 · Cited by 327 · see citing works
Identification of a Signaling Network in Lateral Nucleus of Amygdala Important for Inhibiting Memory Specifically Related to Learned Fear
Shumyatsky, G. P., Tsvetkov, E., Malleret, G., Vronskaya, S., Hatton, M., Hampton, L. L., Battey, J. F., Dulac, C. G., Kandel, E. R., & Bolshakov, V. Y. (2002) · Cell · doi:10.1016/s0092-8674(02)01116-9 · Cited by 324 · see citing works
Evidence for neurotransmitter plasticity in vivo: Developmental changes in properties of cholinergic sympathetic neurons
Landis, S. C., & Keefe, D. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90365-2 · Cited by 324 · see citing works
Immunofluorescence of vasopressin and oxytocin in the rat hypothalamo-neurohypophyseal system
Swaab, D. F., Pool, C. W., & Nijveldt, F. (1975) · Journal of Neural Transmission · doi:10.1007/bf01253126 · Cited by 323 · see citing works
Serotonin 5-HT1A Receptors as Targets for Agents to Treat Psychiatric Disorders: Rationale and Current Status of Research
Celada, P., Bortolozzi, A., & Artigas, F. (2013) · CNS Drugs · doi:10.1007/s40263-013-0071-0 · Cited by 323 · see citing works
Molecular Mechanisms and Therapeutical Implications of Intramembrane Receptor/Receptor Interactions among Heptahelical Receptors with Examples from the Striatopallidal GABA Neurons
Agnati, L. F., Ferré, S., Lluı́s, C., Franco, R., & Fuxé, K. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.2 · Cited by 322 · see citing works
Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression
Culverhouse, R., Saccone, N. L., Horton, A. C., Ma, Y., Anstey, K. J., Banaschewski, T., Burmeister, M., Cohen‐Woods, S., Étain, B., Fisher, H. L., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.44 · Cited by 321 · see citing works
Galanin-like immunoreactivity in cholinergic neurons of the septum-basal forebrain complex projecting to the hippocampus of the rat
Melander, T., Staines, W. A., Hökfelt, T. G. M., Rökaeus, Å., Eckenstein, F. P., Salvaterra, P. M., & Wainer, B. H. (1985) · Brain Research · doi:10.1016/0006-8993(85)91228-4 · Cited by 318 · see citing works
Increased turnover of norepinephrine in the rat cerebral cortex during stress: role of the locus coeruleus
Korf, J., Aghajanian, G. K., & Roth, R. H. (1973) · Neuropharmacology · doi:10.1016/0028-3908(73)90024-5 · Cited by 311 · see citing works
miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment
Lopez, J. P., Lim, R., Cruceanu, C., Crapper, L., Fasano, C., Labonte, B., Maussion, G., Yang, J. P., Yerko, V., Vigneault, E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3582 · Cited by 308 · see citing works
How reliable are G-protein-coupled receptor antibodies?
Michel, M. C., Wieland, T., & Tsujimoto, G. (2009) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-009-0395-y · Cited by 306 · see citing works
Functional consequences of neuropeptide and small-molecule co-transmission
Nusbaum, M. P., Blitz, D. M., & Marder, E. E. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.56 · Cited by 304 · see citing works
Molecular studies of major depressive disorder: the epigenetic perspective
Mill, J. S., & Petronis, A. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001992 · Cited by 302 · see citing works
Autoradiographic distribution of 125I-galanin binding sites in the rat central nervous system
Skofitsch, G., Sills, M. A., & Jacobowitz, D. M. (1986) · Peptides · doi:10.1016/0196-9781(86)90133-6 · Cited by 302 · see citing works
The Neuropeptide Y (NPY)-ergic System is Associated with Behavioral Resilience to Stress Exposure in an Animal Model of Post-Traumatic Stress Disorder
Cohen, H., Liu, T., Kozlovsky, N., Kaplan, Z., Zohar, J., & Mathé, A. A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.230 · Cited by 299 · see citing works
LRF producing cells of the mammalian hypothalamus
Barry, J. G., Dubois, M. P., & Poulain, P. (1973) · Cell and Tissue Research · doi:10.1007/bf02346227 · Cited by 299 · see citing works
Functional studies of cotransmission.
Kupfermann, I. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.3.683 · Cited by 298 · see citing works
Neurotrophins: a family of proteins supporting the survival of neurons.
Barde, Y. (1994) · PubMed · Cited by 296 · see citing works
THE ROLE OF VESICULAR TRANSPORT PROTEINS IN SYNAPTIC TRANSMISSION AND NEURAL DEGENERATION
Liu, Y., & Edwards, R. H. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.125 · Cited by 295 · see citing works
Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression
Klempan, T. A., Sequeira, A., Canetti, L., Lalovic, A., Ernst, C., ffrench-Mullen, J., & Turecki, G. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002110 · Cited by 294 · see citing works
Noradrenergic modulation of midbrain dopamine cell firing elicited by stimulation of the locus coeruleus in the rat
Grenhoff, J., Nisell, M., Ferr�, S., Aston‐Jones, G., & Svensson, T. H. (1993) · Journal of Neural Transmission · doi:10.1007/bf01244934 · Cited by 292 · see citing works
Ventrolateral preoptic nucleus contains sleep-active, galaninergic neurons in multiple mammalian species
Gaus, S. E., Strecker, R. E., Tate, B. A., Parker, R. A., & Saper, C. B. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00308-1 · Cited by 288 · see citing works
Lack of Efficacy of the Substance P (Neurokinin1 Receptor) Antagonist Aprepitant in the Treatment of Major Depressive Disorder
Keller, M., Montgomery, S., Ball, W., Morrison, M., Snavely, D., Liu, G., Hargreaves, R., Hietala, J., Lines, C., Beebe, K., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.07.013 · Cited by 286 · see citing works
The discovery of central monoamine neurons gave volume transmission to the wired brain
Fuxé, K., Dahlström, A. B., JONSSON, G., Marcellino, D. J., Guescini, M., Dam, M., Manger, P. R., & Agnati, L. F. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.012 · Cited by 285 · see citing works
Neurotransmitter Corelease: Mechanism and Physiological Role
Hnasko, T. S., & Edwards, R. H. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153315 · Cited by 284 · see citing works

Flagged first, then by citations

5 of the 625 references couldn’t be matched to a known paper.

Research works printed but not linked: 7

Bremner J. D. Krystal J. H. Southwick S. M. Charney D. S. (1996b). Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. Synapse 23 39– 51. 8723134
Hokfelt T. Johansson O. Goldstein M. (1984). “Central catcholamine neurons as revelaed by immunohistochemistry with special reference to adrenaline neurons,” in Handbook of Chemical Neuroanatomy. Vol. 2: Classical Transmitters in the CNS eds Björklund A. Hokfelt T. (Amsterdam: Elsevier) 157– 276.
Maes M. Meltzer H. Y. (1995). “The serotonin hypothesis of major depression,” in Psychopharmacology: The Fourth Generation of Progress eds Bloom F. Kupfer D. (New York, NY: Raven Press Ltd) 933– 944.
Mutt V. (1989). Hormonal Peptides, Fidia Research Foundation Neuroscience Award Lectures. New York, NY: Raven Press 125– 218.
O’Donnell D. F. M. Hoffert C. Hubatsch D. Pelletier M. Walker P. Ahmad S. (2003). “Localization of galanin receptor subtypes in the rat CNS,” in Handbook of Chemical Neuroanatomy Vol. 20 Peptide Receptors eds Quirion R. Bjorklnud A. Hokfelt T. (Amsterdam: Elsevier) 195– 244.
Schatzberg A. S. Schildkraut J. J. (1995). “Recent studies on norepinephrine systems im mood disorders,” in Psychopharmacology: The Fourth Generation of Progress eds Bloom F. Kupfer D. (New York, NY: Raven Press) 911– 920.
Steckler T. (2008). “Peptide receptor ligands to treat anxiety disorders,” in Handbook of Anxiety and Fear eds Blanchard D. C. Blanchard D. C. Griebel G. Nutt D. (Amsterdam: Elsevier) 157– 217.

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Bakalar, D., Sweat, S. C., Drossel, G., Jiang, S. Z., Samal, B. B., Stroth, N., Xu, W., Zhang, L., Zhang, H., & Eiden, L. E. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105447 · Cited by 10 · see citing works
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De‐Miguel, F. F., Leon-Pinzon, C., Torres-Platas, S. G., del-Pozo, V., Hernández-Mendoza, G. A., Aguirre-Olivas, D., Méndez, B., Moore, S., Sánchez-Sugía, C., García-Aguilera, M. A., et al. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.638858 · Cited by 10 · see citing works
Examining ventral subiculum and basolateral amygdala projections to the nucleus accumbens shell: Differential expression of VGLuT1, VGLuT2 and VGaT in the rat
Jin, S., Maddern, X. J., Campbell, E. J., & Lawrence, A. J. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136858 · Cited by 9 · see citing works
Classifying Drosophila Olfactory Projection Neuron Boutons by Quantitative Analysis of Electron Microscopic Reconstruction
Yang, K., Liu, T., Wang, Z., Liu, J., Shen, Y., Pan, X., Wen, R., Xie, H., Ruan, Z., Tan, Z., et al. (2021) · iScience · doi:10.1016/j.isci.2022.104180 · Cited by 9 · see citing works
Beneficial effects of galanin system on diabetic peripheral neuropathic pain and its complications
Yu, M., Fang, P., Wang, H., Shen, G., Zhang, Z., & Tang, Z. (2020) · Peptides · doi:10.1016/j.peptides.2020.170404 · Cited by 9 · see citing works
Brain transcriptome response to Streptococcus agalactiae infection and the heterogeneous regulation of neuropeptides on immune response in tilapia, Oreochromis niloticus
Li, Q., Liu, R., Ma, R., Huang, Y., Zhang, L., Zheng, Z., Zheng, Z., Li, X., Chen, C., Chen, C., et al. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738222 · Cited by 9 · see citing works
Sex-Specific Differences in Rodents Following a Single Primary Blast Exposure: Focus on the Monoamine and Galanin Systems
Kawa, L., Arborelius, U. P., Hökfelt, T. G. M., & Risling, M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.540144 · Cited by 9 · see citing works
Analgesic effect of central relaxin receptor activation on persistent inflammatory pain in mice: behavioral and neurochemical data
Abboud, C., Brochoire, L., Drouet, A., Hossain, M. A., Hleihel, W., Gundlach, A. L., & Landry, M. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000937 · Cited by 8 · see citing works
Oxytocinergic neurons, but not oxytocin, are crucial for male penile erection
Wen, Y., Fan, L., Yang, A.-Y., Zhang, Y.-C., Xu, C., Wang, Z.-H., Xie, W.-J., Lu, Y., Zhang, X., Zhu, J., et al. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109576 · Cited by 8 · see citing works
Long-Term Dynamics of Serum α-MSH and α-MSH-Binding Immunoglobulins with a Link to Gut Microbiota Composition in Patients with Anorexia Nervosa
Seitz, J., Lahaye, E., Andreani, N. A., Thomas, B. J., Takhlidjt, S., Chartrel, N., Herpertz‐Dahlmann, B., Baines, J. F., & Fetissov, S. O. (2024) · Neuroendocrinology · doi:10.1159/000539316 · Cited by 8 · see citing works
Chronic Spinal Cord Injury Reduces Gastrin-Releasing Peptide in the Spinal Ejaculation Generator in Male Rats
Wiggins, J. W., Kozyrev, N., Sledd, J. E., Wilson, G. G., & Coolen, L. M. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2019.6509 · Cited by 8 · see citing works
Fronto-temporal galanin modulates impulse control
Messanvi, F., Perkins, A., du Hoffmann, J., & Chudasama, Y. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05365-2 · Cited by 8 · see citing works
Involvement of Scratch2 in GalR1-mediated depression-like behaviors in the rat ventral periaqueductal gray
Yang, Y., Li, Y., Liu, B., Li, C., Liu, Z., Deng, J., Luo, H., Li, X., Wu, J., Li, H., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922586118 · Cited by 8 · see citing works
Modulating brain integrative actions as a new perspective on pharmacological approaches to neuropsychiatric diseases
Marcoli, M., Agnati, L. F., Franco, R., Cortelli, P., Anderlini, D., Guidolin, D., Cervetto, C., & Maura, G. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1038874 · Cited by 7 · see citing works
Prenatal and postnatal challenges affect the hypothalamic molecular pathways that regulate hormonal levels
Rodriguez‐Zas, S. L., Southey, N. L., Rund, L. A., Antonson, A. M., Nowak, R. A., & Johnson, R. W. (2023) · PLoS ONE · doi:10.1371/journal.pone.0292952 · Cited by 7 · see citing works
Galanin Protects Rat Cortical Astrocyte from Oxidative Stress: Involvement of GalR2 and pERK1/2 Signal Pathway
Sun, J., Xu, S. Q., Li, H., Li, L., & Xu, Q. (2019) · Mediators of Inflammation · doi:10.1155/2019/2716028 · Cited by 7 · see citing works
Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender
Pulver, A., Kiive, E., Kanarik, M., & Harro, J. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147013 · Cited by 7 · see citing works
Epigenesis, Synapse Selection, Cultural Imprints, and Human Brain Development
Changeux, J. (2022) · Cambridge University Press eBooks · doi:10.1017/9781108399838.004 · Cited by 6 · see citing works
Neuropeptides as transmitters and regulators of the locus coeruleus noradrenergic system
Becker, L. J., Martin, M. M., Hughes, A. C., Mulvey, B., Kuo, C., Piantadosi, S. C., Bruchas, M. R., Martinowich, K., Meye, F. J., Schwarz, L. A., et al. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100081 · Cited by 5 · see citing works
Genetic-epigenetic-neuropeptide associations in mood and anxiety disorders: Toward personalized medicine
Gilani, M., Abak, N., & Saberian, M. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173897 · Cited by 6 · see citing works
Central administration of p234, kisspeptin antagonist, but not kisspeptin-10, reduces the power of epileptiform activity and slow EEG waves in male rats
Kalkan, Ö. F., Şahin, Z., Aktaş, O., Yildirim, A., Aydın-Abidin, S., Özyaşar, A. F., Uzun, İ., & Abidin, İ. (2025) · Neurological Research · doi:10.1080/01616412.2025.2456293 · Cited by 6 · see citing works
Blood Levels of Neuropeptide 26RFa in Relation to Anxiety and Aggressive Behavior in Humans—An Exploratory Study
Værøy, H., Takhlidjt, S., Cherifi, Y., Lahaye, E., Chartrel, N., & Fetissov, S. O. (2023) · Brain Sciences · doi:10.3390/brainsci13020237 · Cited by 6 · see citing works
The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet
McEwan, A. R., Erickson, J. C., Davidson, C., Heijkoop, J., Turnbull, Y. D., Delibegović, M., Murgatroyd, C., & MacKenzie, A. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03705-6 · Cited by 6 · see citing works
Expression of substance P, NPY and their Receptors Is Altered in Major DepressionPreprint
Barde, S. S., Benitez, J. A., Zhong, W., Solarz, A., Mei, I., Prud’homme, J., Palkovits, M., Turecki, G., Mulder, J., Uhlén, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.14.516867 · Cited by 6 · see citing works
Spatially Mapping Neuropeptide Isomers via MALDI Trapped Ion Mobility MS Imaging
Okyem, S., Trinklein, T. J., Rubakhin, S. S., & Sweedler, J. V. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c04297 · Cited by 5 · see citing works
Evolution of neuropeptides: From diffusing molecules to modulators of synaptic transmission
Leroy, F., Gimenez, P., Krabichler, Q., & Grinevich, V. (2026) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2026.102920 · Cited by 5 · see citing works
Influence of Testosterone Depletion on Neurotrophin-4 in Hippocampal Synaptic Plasticity and Its Effects on Learning and Memory
Muthu, S., Lakshmanan, G., & Prakash, S. (2022) · Developmental Neuroscience · doi:10.1159/000522201 · Cited by 5 · see citing works
Distinct neurochemical influences on fMRI response polarity in the striatumPreprint
Cerri, D. H., Albaugh, D. L., Walton, L. R., Katz, B. M., Wang, T.-W. W., Chao, T.-H. H., Zhang, W., Nonneman, R. J., Jiang, J., Lee, S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.20.529283 · Cited by 5 · see citing works
The Thermodynamically Expensive Contribution of Three Calcium Sources to Somatic Release of Serotonin
De‐Miguel, F. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031495 · Cited by 4 · see citing works
Cholecystokinin B receptor gene polymorphism (rs2941026) is associated with anxious personality and suicidal thoughts in a longitudinal study
Lvovs, A., Matrov, D., Kurrikoff, T., Veidebaum, T., & Harro, J. (2021) · Acta Neuropsychiatrica · doi:10.1017/neu.2021.41 · Cited by 4 · see citing works
Of artificial intelligence, machine learning, and the human brain. Celebrating Miklos Palkovits' 90th birthday
Ágoston, D. V. (2024) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2024.1374864 · Cited by 4 · see citing works
Association Between Polymorphisms in the 5′ Region of the GALR1 Gene and Schizophrenia in the Northern Chinese Han Population: A Case–Control Study
Li, Y., Gao, M., Zeng, K., Xing, J., Xu, F., Xuan, J., Xia, X., Liu, Y., Yao, J., & Wang, B. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s256644 · Cited by 4 · see citing works
Review of Fish Neuropeptides: A Novel Perspective on Animal Welfare
Campos‐Sánchez, J. C., Cabrera-Álvarez, M. J., & Saraiva, J. L. (2025) · The Journal of Comparative Neurology · doi:10.1002/cne.70029 · Cited by 3 · see citing works
Molecular aspects of regeneration and neuroprotection in neuropsychiatric diseases
Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821711-5.00008-5 · Cited by 2 · see citing works
Chronic Ultrasound Prenatal Stress Altered the Brain’s Neurochemical Systems in Newborn Rats
Abramova, O. V., Zorkina, Y., Ka, P., Ushakova, V. M., Morozova, A. Y., Zubkov, E. A., Pavlova, O., Storozheva, Z. I., Gurina, O. I., & Chekhonin, V. P. (2024) · Neural Plasticity · doi:10.1155/2024/3829941 · Cited by 3 · see citing works
Overview of CNS Organization and Development
Brown, R. E. (2023) · Springer eBooks · doi:10.1007/978-3-031-20792-1_1 · Cited by 3 · see citing works
Escitalopram alters local expression of noncanonical stress-related neuropeptides in the rat brain via NPS receptor signaling
Piwowarczyk-Nowak, A., Pałasz, A., Suszka‐Świtek, A., Vecchia, A. D., Grajoszek, A., Krzystanek, M., & Worthington, J. J. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00374-z · Cited by 2 · see citing works
Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides
Edmond, K. Z., & Matosin, N. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100739 · Cited by 2 · see citing works
Somatostatin neurons of the bed nucleus of the stria terminalis drive aversive behaviors in mice
Denis, Q., Simbriger, K., Iyer, H., Gasser, E., Bukovac, A., Moser, K. V., Hörtnagl, H., & Tasan, R. O. (2026) · Neuropeptides · doi:10.1016/j.npep.2026.102607 · Cited by 2 · see citing works
Antidepressant‐ and Anxiolytic‐Like Effect of the Froriepia subpinnata Extract in the Rat: Neurochemical Correlates
Samandari-Bahraseman, M. R., Esmaeilzadeh‐Salestani, K., Dogani, M., Khaleghdoust, B., Hatami, N., Esmaeili‐Mahani, S., Elyasi, L., Loit, E., & Harro, J. (2024) · Brain and Behavior · doi:10.1002/brb3.70171 · Cited by 2 · see citing works
Galanin receptor 1 expressing neurons in hippocampal-prefrontal circuitry modulate goal directed attention and impulse control
Messanvi, F., Visocky, V., Senneca, C., Berkun, K., Taori, M., Bradley, S. P., Wang, H., Tejeda, H. A., & Chudasama, Y. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02360-y · Cited by 2 · see citing works
An analytical method to measure the contribution of clear synaptic and dense-core peri-synaptic vesicles to neurotransmitter release from synaptic terminals with two classes of secretory vesicles
Trueta, C. (2021) · MethodsX · doi:10.1016/j.mex.2021.101374 · Cited by 2 · see citing works
Neuropeptide Binding Autoantibodies Regulating Neuroendocrine Communications
Fetissov, S. O., & Mehdi, M. E. (2023) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-21358-8_8 · Cited by 2 · see citing works
The therapeutic potential of galanin in the management of pain – a review article
Hökfelt, T. G. M., & Wiesenfeld‐Hallin, Z. (2024) · Danish Medical Journal · doi:10.61409/a10230653 · Cited by 1 · see citing works
Spontaneous and evoked angiotensin II sniffer cell activity in the lamina terminalis in vitro
Farmer, G. E., & Cunningham, J. T. (2024) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00227.2023 · Cited by 1 · see citing works
Neuronal synchronization in Drosophila
Fernández-Chiappe, F., Wappner, M., Morelli, L. G., & Muraro, N. I. (2025) · iScience · doi:10.1016/j.isci.2025.112942 · Cited by 1 · see citing works
Cholesterol modulates trafficking of galanin receptor subtype 1 but not subtype 2: Insights from live‐cell imaging
Li, T., Vukojević, V. B., Oasa, S., Bai, Y., Yang, Y., Li, H., Tang, Y., Terenius, L. Y., Hökfelt, T. G. M., Svenningsson, P., et al. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70192 · Cited by 1 · see citing works
Chemical multiplexing in the nervous system: molecular architecture, functional stratification, and pathophysiological plasticity of neuropeptide-classical neurotransmitter cotransmission
Merighi, A., Sbriz, M., & Lossi, L. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1839947 · Cited by 1 · see citing works
The priming factor, CAPS, mediates somatic exocytosis of serotonin
Laguna, J. A., Saroj, N., Winchell, C. J., Weisblat, D. A., & De‐Miguel, F. F. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.07.026 · Cited by 1 · see citing works

Neuropeptides in the human postmortem brain : focus on galanin and its receptors in depression
Barde, S. S. (2016) · Figshare
Galanin – 25 years with a multitalented neuropeptide
Kuteeva, E., Hökfelt, T. G. M., Wardi, T., & Ögren, S. O. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8160-9 · Cited by 92 · see citing works
Recent Updates on The Role of Galanin and Its Receptors in Regulating Depressive Symptoms
Bing, X., Yin-Yan, M., Jing, L., Yong-Hui, L., & Zhang, J. (2022) · Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) · doi:10.16476/j.pibb.2021.0335
Alterations in the neuropeptide galanin system in major depressive disorder involve levels of transcripts, methylation, and peptide
Barde, S. S., Rüegg, J., Prud’homme, J., Ekström, T. J., Palkovits, M., Turecki, G., Bagdy, G., Ihnatko, R., Theodorsson, E., Juhász, G., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617824113 · Cited by 58 · see citing works
Galanin, Galanin Receptor Subtypes and Depression-Like Behaviour
Kuteeva, E., Hökfelt, T. G. M., Wardi, T., & Ögren, S. O. (2010) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-0346-0228-0_12 · Cited by 102 · see citing works

Authors: Hökfelt, T., Barde, S., Xu, Z.-Q. D., Kuteeva, E., Rüegg, J., Le Maitre, E., Risling, M., Kehr, J., Ihnatko, R., Theodorsson, E., Palkovits, M., Deakin, W., Bagdy, G., Juhasz, G., Prud’homme, H. J., Mechawar, N., Diaz-Heijtz, R., & Ögren, S. O.
Affiliations: Karolinska Institutet (SE)
Linköping University (SE)
Douglas Mental Health University Institute (CA)
Corresponding author: Hökfelt, Tomas
ORCID: Hökfelt, Tomas
Barde, Swapnali
Kuteeva, Eugenia
Risling, Mårten
Ihnatko, Robert
Theodorsson, Elvar
Mechawar, Naguib
Ögren, Sven Ove
Venue: Frontiers in Neural Circuits
Publisher: Frontiers Media SA
Published: 2018-12-21
Volume: 12
Pages: 106-106
ISSN: 1662-5110 (ISSN-L)
DOI: 10.3389/fncir.2018.00106
PMC: PMC6309708
OpenAlex: W2906160505
Cited by: 139
References: 625
Citations by year: 2026: 14 · 2025: 16 · 2024: 23 · 2023: 13 · 2022: 24 · 2021: 22 · 2020: 18 · 2019: 8 · 2018: 1
FWCI: 1.58
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Neural Circuits (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion, other-oa)
Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion, other-oa)
DiVA (Linkoping University) (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Torsten Söderbergs Stiftelse
National Alliance for Research on Schizophrenia and Depression
Karolinska Institutet
Vetenskapsrådet (04X-2887)
Marcus och Amalia Wallenbergs minnesfond
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: neuropeptides, co-transmission, galanin, galanin receptors, locus coeruleus, noradrenergic neurons, depression, major depressive disorder, stress resilience, allostatic load, postmortem brain, suicide, antidepressant mechanism, childhood adversity, anxiety, coexistence of neurotransmitters
MeSH terms: Animals, Mental Disorders, Humans, Locus Coeruleus, Neuropeptides, Receptors, Neurotransmitter, Neurotransmitter Agents

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Neuropeptide and small transmitter coexistence: Fundamental studies and relevance to mental illness

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